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General Information
Symbol
Dmel\sbbEal17
Species
D. melanogaster
Name
FlyBase ID
FBal0193242
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C18282468T

    Amino acid change:

    Q1621term | sbb-PD; Q1631term | sbb-PG; Q1621term | sbb-PH; Q1631term | sbb-PJ

    Reported amino acid change:

    Q1621term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    The mutation truncates the sbbB isoform but leaves the sbbA isoform unchanged.

    Amino acid replacement: Q1621term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous pharate adults have normal aristae. Their legs occasionally have a severely reduced tarsal claw (7% of animals have at least one claw affected), although the pulvilli and empodium are unaffected.

    The ocellar triangle region is compressed in homozygous and sbb6/sbbEal17 flies, resulting in fusion of ocelli, loss of interocellar bristles and loss and mispositioning of the ocellar bristles.

    Legs of homozygotes sometimes fuse and have defective segmentation. The most dramatic fusions are seen between adjacent prothoracic legs.

    24% of sbbEal17/sbb6 pharate adults have defective claws.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    sbb[+]/sbbEal17 is an enhancer of visible phenotype of alush/al130

    Other
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    sbbEal17/+ ; GugEal15/+ and sbbEal17/+ ; groEal13/+ double heterozygotes have defective ocellar triangles.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (1)