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General Information
Symbol
Dmel\Bx1
Species
D. melanogaster
Name
FlyBase ID
FBal0001431
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The roo{}Bx1 insertion is within the 3' untranslated region of Bx.

Insertion of approximately 8kb into the 3' UTR.

Insertion of a roo element.

Insertion components
roo{}Bx1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Bx1 mutant larvae have reduced haemocyte counts while both Bx1/Bx1 and Bx1/+ larvae show higher numbers of crystal cells when compared to controls.

Mutant flies show increased resistance to ethanol sedation compared to control flies.

Heterozygotes show loss of the posterior wing margin. Homozygotes show loss of both anterior and posterior wing margin.

Wing discs in heterozygous larvae show ectopic apoptosis.

Heterozygotes show scalloping of the wing margin.

Mutant animals exhibit an decreased sensitivity to cocaine.

Homozygotes have a scalloped wing phenotype.

Heterozygotes show mild scalloping of the wing in the posterior compartment.

Homozygous flies show severe scalloping of the wing margin and transformation of dorsal to ventral fate in the alula at the posterior margin of the wing. Heterozygous flies show mild notching of the wing.

Male and homozygous female with Beaded-like wings; long, narrow and excised along both margins; fully viable. Heterozygous female less extreme and overlaps wild type. Some venation abnormality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Bx1 has visible | dominant phenotype, enhanceable by caps65.2/caps[+]

Bx1 has visible | dominant phenotype, enhanceable by trn28.4/trn[+]

Bx1 has visible | dominant phenotype, enhanceable by lilli00632/lilli[+]

Bx1 has visible | dominant phenotype, enhanceable by Df(2L)C144/+

Bx1 has visible | dominant phenotype, enhanceable by sbb[+]/sbb6

Bx1 has visible | dominant phenotype, enhanceable by Df(2R)Jp1/+

Bx1 has visible | dominant phenotype, enhanceable by Df(2L)spd/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3L)29A6/+

Bx1 has visible | dominant phenotype, enhanceable by shn1/shn[+]

Bx1 has visible | dominant phenotype, enhanceable by shn04738/shn[+]

Bx1 has visible | dominant phenotype, enhanceable by Df(3L)HR370/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3L)HR232/+

Bx1 has visible | dominant phenotype, enhanceable by Pcif1EY11352/CG11399[+]

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)3450/+

Bx1 has visible | dominant phenotype, enhanceable by l(3)0470804708/l(3)04708[+]

Bx1 has visible | dominant phenotype, enhanceable by Mpcp200564/Mpcp[+]

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Cha7/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Antp17/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)Tpl10/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)p40/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)p712/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)by10/+

Bx1 has visible | dominant phenotype, enhanceable by cic[+]/cicD49

Bx1 has visible | dominant phenotype, enhanceable by Df(3L)Cat/+

Bx1 has visible | dominant phenotype, enhanceable by tara1/tara[+]

Bx1 has visible | dominant phenotype, enhanceable by tara03881/tara[+]

Bx1 has visible | dominant phenotype, enhanceable by nufKG02305/nuf[+]

Bx1 has visible | dominant phenotype, enhanceable by Df(3L)XS572/+

Bx1 has visible | dominant phenotype, enhanceable by Df(3R)M-Kx1/+

Bx1 has visible | dominant phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)17

Bx1 has visible | dominant phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)S-192

Bx1 has visible | dominant phenotype, enhanceable by ap[+]/apUGO35

Bx1 has visible | dominant phenotype, enhanceable by fng[+]/fng80

Bx1 has visible | dominant phenotype, enhanceable by osa[+]/osa308

Bx1 has visible | dominant phenotype, enhanceable by Ser[+]/SerRX82

Bx1 has visible | dominant phenotype, enhanceable by brmT362/brm[+]

Bx1 has visible phenotype, enhanceable by ap[+]/apmd544

Bx1 has visible phenotype, enhanceable by Df(1)C246/+

Bx1 has visible phenotype, enhanceable by Df(1)N19/+

Bx1 has visible phenotype, enhanceable by Df(2R)vg-C/+

Bx1 has visible phenotype, enhanceable by Df(3L)AC1/+

Bx1 has visible phenotype, enhanceable by +/Df(3L)brm11

Bx1 has visible phenotype, enhanceable by +/Df(3R)D605

Bx1 has visible phenotype, enhanceable by Df(3R)DG2/+

Bx1 has visible phenotype, enhanceable by Df(3R)M-Kx1/+

Bx1 has visible phenotype, enhanceable by In(3LR)C190LUbx42TR/+

Bx1 has visible phenotype, enhanceable by caps05121/caps[+]

Bx1 has visible phenotype, enhanceable by trnΔ2.9/caps65.2

Bx1 has visible phenotype, enhanceable by trn28.4/trn[+]

Bx1 has visible phenotype, enhanceable by Df(2L)al/+

Bx1 has visible phenotype, enhanceable by +/Df(1)ct-J4

Bx1 has visible phenotype, enhanceable by Df(2R)CX1/+

Bx1 has visible phenotype, enhanceable by Df(2R)E3363/+

Bx1 has visible phenotype, enhanceable by +/Df(2R)M41A4

Bx1 has visible phenotype, enhanceable by Df(2R)Np5/+

Bx1 has visible phenotype, enhanceable by Df(2R)X58-12/+

Bx1 has visible phenotype, enhanceable by Df(2R)nap1/+

Bx1 has visible phenotype, enhanceable by Df(2R)or-BR6/+

Bx1 has visible | dominant phenotype, enhanceable by Chie5.5

Bx1 has visible | dominant phenotype, enhanceable by apUGO35

Bx1 has visible | dominant phenotype, enhanceable by fng80

NOT Enhanced by
Statement
Reference

Bx1 has visible | dominant phenotype, non-enhanceable by mir-14[+]/mir-14Δ1

Bx1 has visible | dominant phenotype, non-enhanceable by cbt[+]/cbtEP2237E28

Bx1 has visible | dominant phenotype, non-enhanceable by pnt[+]/pntΔ88

Suppressed by
Statement
Reference

Bx1 has visible | dominant phenotype, suppressible by NAx-M1/N[+]

Bx1 has visible | dominant phenotype, suppressible by H[+]/HE31

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by SlhEP2-18/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by lilliEP2-27/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by cbtEP2-408/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by nmdEP2-446

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by sbbEP2-473/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by drprEP2-867

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/chmEP2-1069

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/shnEP2-1279

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/apEP2-1583

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by shnEP2-1743/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/Pcif1EP3-28

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-473

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/fngEP3-511

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by skdEP3-532

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/fngEP3-581

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-619

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-900

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/osaEP3-1386

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by osaEP3-1591/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by pntEP3-853/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/pntEP3-1638

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by pntEP3-1859/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by cicEP3-1005/Scer\GAL4ap-md544

Bx1, ap[+]/apmd544 has visible phenotype, suppressible by Scer\GAL4ap-md544/nufEP3-1715

Bx1 has visible | dominant phenotype, suppressible by nmdry4/nmd[+]

Bx1 has visible | dominant phenotype, suppressible by drprΔ5/drpr[+]

Bx1 has visible | dominant phenotype, suppressible by drpr[+]/drprΔ19

Bx1 has visible | dominant phenotype, suppressible by drprEP522/drpr[+]

Bx1 has visible | dominant phenotype, suppressible by skdEP3375/skd[+]

Bx1 has visible | dominant phenotype, suppressible by skdL7062/skd[+]

Bx1 has visible | dominant phenotype, suppressible by skd[+]/skdrK760

NOT suppressed by
Statement
Reference

Bx1 has visible | dominant phenotype, non-suppressible by mir-14[+]/mir-14Δ1

Bx1 has visible | dominant phenotype, non-suppressible by cbt[+]/cbtEP2237E28

Bx1 has visible | dominant phenotype, non-suppressible by pnt[+]/pntΔ88

NOT Enhancer of
NOT Suppressor of
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Bx1 has wing margin phenotype, enhanceable by Df(2L)spd/+

Bx1 has wing margin phenotype, enhanceable by Df(3L)29A6/+

Bx1 has wing margin phenotype, enhanceable by shn1/shn[+]

Bx1 has wing margin phenotype, enhanceable by shn04738/shn[+]

Bx1 has wing margin phenotype, enhanceable by Df(3L)HR370/+

Bx1 has wing margin phenotype, enhanceable by Df(3L)HR232/+

Bx1 has wing margin phenotype, enhanceable by Pcif1EY11352/CG11399[+]

Bx1 has wing margin phenotype, enhanceable by Df(3R)3450/+

Bx1 has wing margin phenotype, enhanceable by l(3)0470804708/l(3)04708[+]

Bx1 has wing margin phenotype, enhanceable by Mpcp200564/Mpcp[+]

Bx1 has wing margin phenotype, enhanceable by Df(3R)Cha7/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)Antp17/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)Tpl10/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)p40/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)p712/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)by10/+

Bx1 has wing margin phenotype, enhanceable by cic[+]/cicD49

Bx1 has wing margin phenotype, enhanceable by Df(3L)Cat/+

Bx1 has wing margin phenotype, enhanceable by tara1/tara[+]

Bx1 has wing margin phenotype, enhanceable by tara03881/tara[+]

Bx1 has wing margin phenotype, enhanceable by nufKG02305/nuf[+]

Bx1 has wing margin phenotype, enhanceable by Df(3L)XS572/+

Bx1 has wing margin phenotype, enhanceable by Df(3R)M-Kx1/+

Bx1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)17

Bx1 has wing margin phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)S-192

Bx1 has wing margin phenotype, enhanceable by caps65.2/caps[+]

Bx1 has wing margin phenotype, enhanceable by trn28.4/trn[+]

Bx1 has wing margin phenotype, enhanceable by lilli00632/lilli[+]

Bx1 has wing margin phenotype, enhanceable by Df(2L)C144/+

Bx1 has wing margin phenotype, enhanceable by sbb[+]/sbb6

Bx1 has wing margin phenotype, enhanceable by Df(2R)Jp1/+

Bx1 has wing margin phenotype, enhanceable by ap[+]/apUGO35

Bx1 has wing margin phenotype, enhanceable by fng[+]/fng80

Bx1 has wing margin phenotype, enhanceable by osa[+]/osa308

Bx1 has wing margin phenotype, enhanceable by Ser[+]/SerRX82

Bx1 has wing margin phenotype, enhanceable by ap[+]/apmd544

Bx1 has wing margin phenotype, enhanceable by brmT362/brm[+]

Bx1 has wing phenotype, enhanceable by Df(1)C246/+

Bx1 has wing phenotype, enhanceable by Df(1)N19/+

Bx1 has wing phenotype, enhanceable by +/Df(1)ct-J4

Bx1 has wing phenotype, enhanceable by Df(2L)al/+

Bx1 has wing phenotype, enhanceable by Df(2R)CX1/+

Bx1 has wing phenotype, enhanceable by Df(2R)E3363/+

Bx1 has wing phenotype, enhanceable by +/Df(2R)M41A4

Bx1 has wing phenotype, enhanceable by Df(2R)Np5/+

Bx1 has wing phenotype, enhanceable by Df(2R)X58-12/+

Bx1 has wing phenotype, enhanceable by Df(2R)nap1/+

Bx1 has wing phenotype, enhanceable by Df(2R)or-BR6/+

Bx1 has wing phenotype, enhanceable by Df(2R)vg-C/+

Bx1 has wing phenotype, enhanceable by Df(3L)AC1/+

Bx1 has wing phenotype, enhanceable by +/Df(3L)brm11

Bx1 has wing phenotype, enhanceable by +/Df(3R)D605

Bx1 has wing phenotype, enhanceable by Df(3R)DG2/+

Bx1 has wing phenotype, enhanceable by Df(3R)M-Kx1/+

Bx1 has wing phenotype, enhanceable by In(3LR)C190LUbx42TR/+

Bx1 has wing phenotype, enhanceable by caps05121/caps[+]

Bx1 has wing phenotype, enhanceable by trnΔ2.9/caps65.2

Bx1 has wing phenotype, enhanceable by trn28.4/trn[+]

Bx1 has wing phenotype, enhanceable by Chie5.5

Bx1 has wing phenotype, enhanceable by apUGO35

Bx1 has wing phenotype, enhanceable by fng80

NOT Enhanced by
Statement
Reference

Bx1 has wing margin phenotype, non-enhanceable by mir-14[+]/mir-14Δ1

Bx1 has wing margin phenotype, non-enhanceable by cbt[+]/cbtEP2237E28

Bx1 has wing margin phenotype, non-enhanceable by pnt[+]/pntΔ88

Suppressed by
Statement
Reference

Bx1 has wing margin phenotype, suppressible by NAx-M1/N[+]

Bx1 has wing margin phenotype, suppressible by H[+]/HE31

Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by nmdEP2-446

Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by drprEP2-867

Bx1, ap[+]/apmd544 has wing margin phenotype, suppressible by skdEP3-532

Bx1 has wing margin phenotype, suppressible by nmdry4/nmd[+]

Bx1 has wing margin phenotype, suppressible by drprΔ5/drpr[+]

Bx1 has wing margin phenotype, suppressible by drpr[+]/drprΔ19

Bx1 has wing margin phenotype, suppressible by drprEP522/drpr[+]

Bx1 has wing margin phenotype, suppressible by skdEP3375/skd[+]

Bx1 has wing margin phenotype, suppressible by skdL7062/skd[+]

Bx1 has wing margin phenotype, suppressible by skd[+]/skdrK760

Bx1 has wing phenotype, suppressible by Scer\GAL4ap-md544/apUAS.cMa

Bx1 has wing phenotype, suppressible by Scer\GAL4ap-md544/fngUAS.cKa

NOT suppressed by
Statement
Reference

Bx1 has wing margin phenotype, non-suppressible by mir-14[+]/mir-14Δ1

Bx1 has wing margin phenotype, non-suppressible by cbt[+]/cbtEP2237E28

Bx1 has wing margin phenotype, non-suppressible by pnt[+]/pntΔ88

NOT Enhancer of
NOT Suppressor of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Bx1/Y ; apmd544/+ males have a strong wing scalloping phenotype.

apmd544/+ enhances the severity of the Bx1 wing scalloping phenotype. The Bx1 scalloped wing phenotype is completely suppressed by expression of apScer\UAS.cMa under the control of Scer\GAL4ap-md544. The Bx1 scalloped wing phenotype is suppressed by expression of fngScer\UAS.cKa or SerScer\UAS.cSa under the control of Scer\GAL4ap-md544. The severity of the Bx1/+ wing scalloping phenotype is enhanced by one copy of apUGO35, fng80, SerRX82, osa308 or brmT362. The Bx1 scalloped wing phenotype is completely suppressed by expression of osaScer\UAS.cCa, osaEP3-900, osaEP3-1591, osaEP3-619, osaEP3-941, osaEP3-473, osaEP3-1074 or osaEP3-1386 under the control of Scer\GAL4ap-md544.

The wing phenotype of Bx1 heterozygotes is dominantly enhanced by apUGO35, fng80 or Chie5.5. The wing phenotype of heterozygotes is completely suppressed by apScer\UAS.cMa expressed under the control of Scer\GAL4ap-md544. The wing scalloping phenotype of heterozygotes is fully rescued by fngScer\UAS.cKa expressed under the control of Scer\GAL4ap-md544, but the transformation phenotype of the alula is not.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of BxGD1385 under the control of Scer\GAL4He.PZ fully rescues the decreased haemocyte count phenotype while it partially rescues the increased crystal cell number phenotype of Bx1 mutants.

Images (1)
Stocks (5)
Notes on Origin
Discoverer

Bridges, 3rd Jan. 1923.

Comments
Comments

Alleles fall into an allelic series based on cocaine resistance phenotype. BxJ > Bx1 = Bx2 = Bx3.

No interaction with Doa alleles is observed.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (19)