FlyBase Allele Report: Dmel\osa[UAS.cCa]

Expression of osa^Scer\UAS.cCa via the Scer\GAL4^en-e16E driver results in a severe wing phenotype, including ectopic wing veins, blistering of the wing blade and reduced wing size.

(Herr et al., 2010)

Expression of osa^Scer\UAS.cCa driven by Scer\GAL4^ey.PU alters the structure of the eye.

(Salzer et al., 2010)

Expression of osa^Scer\UAS.cCa at low levels in all wing disc cells using Scer\GAL4^C-765 results in ectopic vein formation.

Expression of osa^Scer\UAS.cCa in all wing blade cells during imaginal development using Scer\GAL4^MD-638 results in the formation of large territories of vein differentiation in distal wing regions in females, and the formation of smaller wings with ectopic veins in males. Ectopic sensory organs and wing hairs are also observed.

Expression of osa^Scer\UAS.cCa in all wing imaginal cells using Scer\GAL4^nub-AC-62 results in ectopic vein tissue in most of the wing. Only the regions between vein L3 and L4 and the region posterior to L5 differentiate intervein tissue. Ectopic sensory organs and wing hairs are also observed.

(Terriente-Félix and de Celis, 2009)

When osa^Scer\UAS.cCa is driven by Scer\GAL4^pnr-MD237, mutant adults show a thoracic cleft and loss of dorsocentral bristles.

(Heitzler et al., 2003)

When osa^Scer\UAS.cCa is driven by Scer\GAL4^GMR.PF a mild rough eye phenotype is seen.

(Brumby et al., 2002)

osa^Scer\UAS.cCa when driven by Scer\GAL4^vg.PM produces flies with small wings that lack proximal hinge structures. Expression of osa^Scer\UAS.cCa in the eye driven by Scer\GAL4^ey.PH results in a variable reduction in eye size. This phenotype is enhanced by adding a second copy of osa^Scer\UAS.cCa and suppressed by the addition of osa³⁰⁸. Expression of osa^Scer\UAS.cCa in the notum driven by Scer\GAL4^pnr-MD237induces the loss of microchaetae near the dorsal midline and a loss of macrochaetae especially the dorsocentrals and the scutellars. Co-expression of osa^{AD.Scer\UAS.T:Hsim\VP16} and osa^Scer\UAS.cCa gives a stronger phenotype than either alone. Expression of osa^Scer\UAS.cCa driven by Scer\GAL4^bi-omb-Gal4 results in dominant pupa lethality. A small number of flies do eclose with deformed wings.

(Collins et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, osa^UAS.cCa has visible phenotype, suppressible | partially by Scer\GAL4^en-e16E/geminin^UAS.cQa

(Herr et al., 2010)

Enhancer of

Statement

Reference

osa^UAS.cCa, Scer\GAL4^GMR.PU is an enhancer of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

NOT Enhancer of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a non-enhancer of visible phenotype of ct^K

(Krupp et al., 2005)

Suppressor of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^hs.PU is a suppressor of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

osa^UAS.cCa/Scer\GAL4^ap-md544 is a suppressor of visible phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a suppressor of visible phenotype of ct^53d

(Krupp et al., 2005)

NOT Suppressor of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a non-suppressor of visible phenotype of ct^K

(Krupp et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, enhanceable by brm^{K804R.UAS.Tag:HA}/Scer\GAL4^ey.PH

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, enhanceable by mor¹

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, enhanceable by Snr1⁰¹³¹⁹

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, enhanceable by brm[+]/brm²

(Collins et al., 1999)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, osa^UAS.cCa has eye phenotype, non-enhanceable by Rbf^GMR.PD

(Brumby et al., 2002)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-enhanceable by ash1²²

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-enhanceable by trx^E2

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-enhanceable by ash2¹

(Collins et al., 1999)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, osa^UAS.cCa has wing vein | ectopic phenotype, suppressible | partially by Scer\GAL4^en-e16E/geminin^UAS.cQa

(Herr et al., 2010)

Scer\GAL4^en-e16E, osa^UAS.cCa has wing phenotype, suppressible | partially by Scer\GAL4^en-e16E/geminin^UAS.cQa

(Herr et al., 2010)

Scer\GAL4^vg.PM, osa^UAS.cCa has wing phenotype, suppressible by brm^{K804R.UAS.Tag:HA}/Scer\GAL4^vg.PM

(Collins et al., 1999)

NOT suppressed by

Statement

Reference

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-suppressible by ash2¹

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-suppressible by ash1²²

(Collins et al., 1999)

Scer\GAL4^ey.PH, osa^UAS.cCa has eye phenotype, non-suppressible by trx^E2

(Collins et al., 1999)

Enhancer of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^salm-459.2 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^salm-459.2, rl^Sem.cUa.UAS

(Terriente-Félix and de Celis, 2009)

osa^UAS.cCa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

osa^UAS.cCa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

osa^UAS.cCa/Scer\GAL4^vg.PM is an enhancer of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

osa^UAS.cCa/Scer\GAL4^vg.PM is an enhancer of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

NOT Enhancer of

Statement

Reference

osa^UAS.cCa is a non-enhancer of wing vein L2 phenotype of Ras85D^GD12553, Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

osa^UAS.cCa is a non-enhancer of wing vein L3 phenotype of Ras85D^GD12553, Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

osa^UAS.cCa is a non-enhancer of wing vein L4 phenotype of Ras85D^GD12553, Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a non-enhancer of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

Suppressor of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^hs.PU is a suppressor of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

osa^UAS.cCa/Scer\GAL4^ap-md544 is a suppressor of wing margin phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a suppressor of wing phenotype of ct^53d

(Krupp et al., 2005)

NOT Suppressor of

Statement

Reference

osa^UAS.cCa/Scer\GAL4^salm-459.2 is a non-suppressor of wing vein phenotype of rho^ve-1, vn¹

(Terriente-Félix and de Celis, 2009)

osa^UAS.cCa/Scer\GAL4^bbg-C96 is a non-suppressor of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of geminin^Scer\UAS.cQa driven by Scer\GAL4^en-e16E strongly suppresses the osa^Scer\UAS.cCa wing phenotype, although some blistering is still detectable.

(Herr et al., 2010)

The formation of ectopic wing veins in flies expressing rl^Sem.cUa.UAS under the control of Scer\GAL4^salm-459.2 is strongly enhanced by over-expression of osa^UAS.cCa.

(Terriente-Félix and de Celis, 2009)

The Bx¹ scalloped wing phenotype is completely suppressed by expression of osa^Scer\UAS.cCa under the control of Scer\GAL4^ap-md544.

(Milan et al., 2004)

The wing phenotypes seen when osa^Scer\UAS.cCa is driven by Scer\GAL4^vg.PM are suppressed by the addition of brm^{K804R.Scer\UAS.T:Ivir\HA1}. Addition of osa^Scer\UAS.cCa suppresses the dominant negative wing phenotypes seen in brm^{K804R.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^vg.PM flies. The variable eye size phenotype caused by expression of osa^Scer\UAS.cCa in the eye driven by Scer\GAL4^ey.PH is enhanced by the addition of mor¹ or Snr1⁰¹³¹⁹. The addition of brm^{K804R.Scer\UAS.T:Ivir\HA1} or brm²/+ also enhances this phenotype. The addition of ash1²² or ash2¹, trx^E2 has no effect on the phenotype.