FlyBase Allele Report: Dmel\cbt[EP2237]

General Information

Symbol

Dmel\cbt^EP2237

Species

D. melanogaster

Name

FlyBase ID

FBal0119644

Feature type

allele

Associated gene

Dmel\cbt

Associated Insertion(s)

P{EP}cbt^EP2237

Carried in Construct

Also Known As

EP(2)2237, EP2237^EP2237

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}cbt^EP2237

Cytology

Description

The P{EP} element is inserted 228 nucleotides 5' to the predicted ATG start codon.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:479,697..479,697 [-]

(Bejarano et al., 2008, Zhao et al., 2008, Munoz-Descalzo et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

abnormal neuroanatomy | pharate adult stage, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

viable | recessive

(Munoz-Descalzo et al., 2005)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

dorsocentral bristle | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

neurite | pharate adult stage, with Scer\GAL4^CCAP.PP

(Zhao et al., 2008)

ocellus, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

scutellar bristle | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

The morphology of Ccap/burs neurons in wandering third instar larvae is largely unchanged by expression of cbt^EP2237 under the control of Scer\GAL4^Ccap.PP compared to controls, although there are fewer and smaller boutons at the peripheral endings. In contrast, P14 pharate adults expressing cbt^EP2237 under the control of Scer\GAL4^Ccap.PP show severe defects in the morphology of these neurons, including the loss of many central neurites and efferent projections, with the remaining efferents having substantially fewer or shorter branches and large varicosities. The defect in the pharate adults appears to be due to an arrest of the remodeling of the Ccap/burs neurons at an early stage of neurite outgrowth, in both the central nervous system and the periphery.

(Zhao et al., 2008)

Mutant larvae expressing cbt^EP2237 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

Expression of cbt^EP2237 under the control of Scer\GAL4^sca-537.4 results in too many or too few scutellar or dorsocentral macrochaetae. Sensory organs with two shafts and one socket, one shaft and no socket, one socket and no shaft and smaller shaft morphology are seen. Ocelli are absent or greatly reduced.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/cbt^EP2237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/cbt^EP2237 is a suppressor of visible phenotype of Bx¹

(Bejarano et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/cbt^EP2237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/cbt^EP2237 is a suppressor of wing margin phenotype of Bx¹

(Bejarano et al., 2008)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237/pnr[+] has microchaeta phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237/pnr[+] has scutellar bristle | increased number phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237 has microchaeta phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, cbt^EP2237, pnr^MD237 has scutellar bristle | increased number phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing cbt^EP2237 under the control of Scer\GAL4^pnr-MD237 have a deformed scutellum, extra scutellar macrochaetae and microchaetae missing in the dorsal midline.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(2)2237

(Munoz-Descalzo et al., 2005, Abdelilah-Seyfried et al., 2000)

EP2237^EP2237

(Pena-Rangel et al., 2002, Kraut et al., 2001, Kraut et al., 2001)

cabut^EP2237

cbt^EP2237

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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