FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\caps05121
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General Information
Symbol
Dmel\caps05121
Species
D. melanogaster
Name
FlyBase ID
FBal0043657
Feature type
allele
Associated gene
Dmel\caps
Associated Insertion(s)
P{PZ}caps05121
Carried in Construct
Also Known As
l(3)05121
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}caps05121
Cytology
Description

The P{PZ} insertion is in the first exon of caps at position 175 of the 2.9kb cDNA.

(Abrell and Jackle, 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      caps05121 embryos show discontinuous dorsal trunk formation.

      (Krause et al., 2006)

      73% of homozygous embryos fail to hatch, though all those that do hatch develop into normal looking larvae. Very few (3%) survive to adulthood. In homozygous mutant embryos, the SNb enters the ventral muscle field and the RP neurons defasciculate normally. Furthermore, RP1, RP3 and RP4 properly synapse with their respective target muscles, whereas the RP5 axons stall, show enlarged growth cone like structures and fail to contact the target muscle. Instead the RP5 axons are split and found also in direct contact with the transversal nerve.

      (Abrell and Jackle, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      caps05121/caps[+] is an enhancer of visible phenotype of Bx1

      (Milan et al., 2001)
      Other
      Statement
      Reference

      Chie5.5, caps05121/caps[+] has visible phenotype

      (Milan et al., 2001)

      Chie5.5, caps05121 has visible phenotype

      (Milan et al., 2001)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      caps05121 has axon phenotype, enhanceable by Kr1/KrmCD

      (Abrell and Jackle, 2001)
      Enhancer of
      Statement
      Reference

      caps05121 is an enhancer of axon phenotype of Kr1, KrmCD

      (Abrell and Jackle, 2001)

      caps05121/caps[+] is an enhancer of wing phenotype of Bx1

      (Milan et al., 2001)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      KrmCD, Kr1/+, caps05121/+ embryos show a SNb nerve phenotype, without affecting the ISN and SNa. In about 1/3 of cases the SNb stops along the ventral longitudinal muscles, ending with a large growth cone structure. In addition properly defasciculated RP axons fail to continue along their normal paths, a portion of them elongate and stall along their normal paths; a portion of them elongate and stall either in a position close to the transversal nerve or are directly connected to it. Kr1, caps05121 double homozygotes (that also carry KrmCD) develop an even stronger phenotype; the SNb is absent in most of the double mutants analysed or do not extend beyond its second choice point close to muscle 28. In only a few cases the SNb stalls in the ventral muscle field.

      (Abrell and Jackle, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      caps02937

      (BDGP Project Members, 1994-1999)
      Comments

      Pan-muscular expression of Kr can partially rescue the SNb phenotype of the Kr1, KrmCD, caps05121 double homozygotes.

      (Abrell and Jackle, 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Excision of the P{PZ} element reverts the phenotype to wild-type.

      (Abrell and Jackle, 2001)

      Complements: stv00543. Complements: l(3)0422004220.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      caps05121
      capsl(3)05121
      (Krause et al., 2006)
      l(3)0293705121
      (BDGP Project Members, 1994-1999)
      l(3)05121
      (Abrell and Jackle, 2001, Milan et al., 2001, Spradling et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)