FlyBase Allele Report: Dmel\cic[D49]

General Information

Symbol

Dmel\cic^D49

Species

D. melanogaster

Name

FlyBase ID

FBal0029622

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

Carried in Construct

Also Known As

cic²

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Roch et al., 2002)

loss of function allele

(Lam et al., 2006)

Mutagen

ethyl methanesulfonate

(Roch et al., 2002, Klein and Campos-Ortega, 1992)

Progenitor genotype

Cytology

Description

Contains a 13bp deletion in exon 3 causing a frameshift about 380bp upstream of the HMG box.

(Roch et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:20,294,771..20,294,783 [+]

Comment:

A 13bp deletion causing a frameshift about 380bp upstream of the HMG box.

(Roch et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with cic¹)

(Roch et al., 2002)

lethal | recessive

(Roch et al., 2002)

lethal - all die during embryonic stage | recessive

(Klein and Campos-Ortega, 1992)

some die during embryonic stage | recessive

(Klein and Campos-Ortega, 1992)

terminal phenotype | germline clone (with cic¹)

(Roch et al., 2002)

Phenotype Manifest In

nervous system

(Klein and Campos-Ortega, 1992)

wing vein | cell non-autonomous | ectopic | somatic clone

(Roch et al., 2002)

wing vein | ectopic (with cic⁰⁸⁴⁸²)

(Roch et al., 2002)

Detailed Description

Statement

Reference

cic^D49/+ animals do not show a wing phenotype.

(Lam et al., 2006)

cic^D49 combined with cic¹ produces animals with a terminal lethal phenotype. Homozygous mutant clones are smaller than controls, they often differentiate as vein tissue in ectopic positions, particularly if they are close to normal veins. These changes are not strictly cell autonomous, as many intervein cells within the mutant clones differentiate normally, and mutant clones can also induce neighbouring wild-type cells to differentiate as vein tissue, either in the same wing surface or in the opposite one.

(Roch et al., 2002)

Homozygotes show weak neural hyperplasia.

(Klein and Campos-Ortega, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cic[+]/cic^D49 is an enhancer of visible | dominant phenotype of Bx¹

(Bejarano et al., 2008)

cic[+]/cic^D49 is an enhancer of visible phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Lam et al., 2006)

cic[+]/cic^D49 is an enhancer of visible phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5

(Lam et al., 2006)

Other

Statement

Reference

bwk^Δ11, cic^D49 has partially lethal phenotype

(Roch et al., 2002)

bwk^Δ81, cic^D49 has lethal - all die during embryonic stage phenotype

(Roch et al., 2002)

bwk^Δ14, cic^D49 has partially lethal phenotype

(Roch et al., 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

bwk^Δ11, cic^D49 has wing vein | ectopic phenotype, non-enhanceable by rho^ve-1/vn¹

(Roch et al., 2002)

Enhancer of

Statement

Reference

cic[+]/cic^D49 is an enhancer of wing margin phenotype of Bx¹

(Bejarano et al., 2008)

cic[+]/cic^D49 is an enhancer of ommatidium phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Lam et al., 2006)

cic[+]/cic^D49 is an enhancer of wing vein L3 phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5

(Lam et al., 2006)

cic[+]/cic^D49 is an enhancer of wing vein | ectopic phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^cv-c-C5

(Lam et al., 2006)

cic[+]/cic^D49 is an enhancer of wing phenotype of Delta^9P

(Klein and Campos-Ortega, 1992)

cic[+]/cic^D49 is an enhancer of wing phenotype of Delta^FE32

(Klein and Campos-Ortega, 1992)

Suppressor of

Statement

Reference

cic^D49 is a suppressor of wing vein | somatic clone phenotype of Ras85D^ΔC40B

(Roch et al., 2002)

Other

Statement

Reference

ca¹, cic^D49 has wing vein | ectopic phenotype

(Ma et al., 2004)

bwk^Δ11, cic^D49 has wing phenotype

(Roch et al., 2002)

bwk^Δ11, cic^D49 has wing vein | ectopic phenotype

(Roch et al., 2002)

bwk^Δ4, cic^D49 has wing vein | ectopic phenotype

(Roch et al., 2002)

bwk^Δ11, cic^D49 has male genitalia phenotype

(Roch et al., 2002)

bwk^Δ14, cic^D49 has wing vein | ectopic phenotype

(Roch et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

cic^D49 combined with bwk^Δ4, bwk⁰⁸⁴⁸², bwk^Δ14 and bwk^Δ11 shows an extra veins phenotype. cic^D49 and bwk^Δ81 is a lethal combination, cic^D49 and bwk^Δ14 or bwk^Δ11 are 'Almost lethal'. bwk^Δ11, cic^D49 animals are 'almost lethal' and have abnormal wings. These wings can have an extra wing vein tissue phenotype, where intervein cells acquire morphological features of vein cells at least partially. This extra tissue is usually close to the normal veins. This wings also have wing blisters. These animals also have defects in the male genitalia. The cuticle plates forming the genitalia are oriented in the opposite direction to those of wild-type. The addition of bwk^Δ11 and vn¹ fails to enhance the extra wing vein phenotype seen in cic^D49/bwk^Δ11 animals.

(Roch et al., 2002)

Xenogenetic Interactions

Statement

Reference

A cic^D49/+ background causes worsened ommatidial disorganization of Scer\GAL4^GMR.PF>Hsap\ATX1^82Q.Scer\UAS-expressing eyes, when flies are raised at room temperature.

Scer\GAL4^C5-driven expression of Hsap\ATX1^82Q.Scer\UAS in a cic^D49/+ background results in more prominent L3 vein thickening and increased ectopic wing vein formation in the posterior part of the interveins compared to expression of Hsap\ATX1^82Q.Scer\UAS in a wild-type background.

(Lam et al., 2006)

Complementation and Rescue Data

Fails to complement

cic¹

(Roch et al., 2002)

Rescued by

cic^D49 is rescued by cic^Tag:HA

(Roch et al., 2002)

Comments

cic^{+tJa.T:Ivir\HA1} significantly reduces the extravein phenotype seen in cic^D49/bwk^Δ14, cic^D49/bwk⁰⁸⁴⁸² and cic^D49/bwk^Δ11 animals.

(Roch et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Fails to complement: bwk⁰⁸⁴⁸².

(Roch et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E(Dl)D49¹

(Klein and Campos-Ortega, 1992)

cic²

(Ajuria et al., 2011, Charroux et al., 2006, Lam et al., 2006, Roch et al., 2002)

cic^D49

(Bejarano et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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