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General Information
Symbol
Dmel\cicD49
Species
D. melanogaster
Name
FlyBase ID
FBal0029622
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cic2
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

A 13bp deletion causing a frameshift about 380bp upstream of the HMG box.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Contains a 13bp deletion in exon 3 causing a frameshift about 380bp upstream of the HMG box.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cicD49/+ animals do not show a wing phenotype.

cicD49 combined with cic1 produces animals with a terminal lethal phenotype. Homozygous mutant clones are smaller than controls, they often differentiate as vein tissue in ectopic positions, particularly if they are close to normal veins. These changes are not strictly cell autonomous, as many intervein cells within the mutant clones differentiate normally, and mutant clones can also induce neighbouring wild-type cells to differentiate as vein tissue, either in the same wing surface or in the opposite one.

Homozygotes show weak neural hyperplasia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

cic[+]/cicD49 is an enhancer of visible | dominant phenotype of Bx1

Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

bwkΔ11, cicD49 has wing vein | ectopic phenotype, non-enhanceable by rhove-1/vn1

Enhancer of
Statement
Reference

cic[+]/cicD49 is an enhancer of wing margin phenotype of Bx1

cic[+]/cicD49 is an enhancer of wing phenotype of Dl9P

cic[+]/cicD49 is an enhancer of wing phenotype of DlFE32

Suppressor of
Statement
Reference

cicD49 is a suppressor of wing vein | somatic clone phenotype of Ras85DΔC40B

Other
Additional Comments
Genetic Interactions
Statement
Reference

cicD49 combined with bwkΔ4, bwk08482, bwkΔ14 and bwkΔ11 shows an extra veins phenotype. cicD49 and bwkΔ81 is a lethal combination, cicD49 and bwkΔ14 or bwkΔ11 are 'Almost lethal'. bwkΔ11, cicD49 animals are 'almost lethal' and have abnormal wings. These wings can have an extra wing vein tissue phenotype, where intervein cells acquire morphological features of vein cells at least partially. This extra tissue is usually close to the normal veins. This wings also have wing blisters. These animals also have defects in the male genitalia. The cuticle plates forming the genitalia are oriented in the opposite direction to those of wild-type. The addition of bwkΔ11 and vn1 fails to enhance the extra wing vein phenotype seen in cicD49/bwkΔ11 animals.

Xenogenetic Interactions
Statement
Reference

A cicD49/+ background causes worsened ommatidial disorganization of Scer\GAL4GMR.PF>Hsap\ATX182Q.Scer\UAS-expressing eyes, when flies are raised at room temperature.

Scer\GAL4C5-driven expression of Hsap\ATX182Q.Scer\UAS in a cicD49/+ background results in more prominent L3 vein thickening and increased ectopic wing vein formation in the posterior part of the interveins compared to expression of Hsap\ATX182Q.Scer\UAS in a wild-type background.

Complementation and Rescue Data
Fails to complement
Rescued by
Comments

cic+tJa.T:Ivir\HA1 significantly reduces the extravein phenotype seen in cicD49/bwkΔ14, cicD49/bwk08482 and cicD49/bwkΔ11 animals.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Fails to complement: bwk08482.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)