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General Information
Symbol
Dmel\ca1
Species
D. melanogaster
Name
FlyBase ID
FBal0001461
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ca
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies show a significant decrease in ommochrome pigment levels and some reduction in drosopterin pigment levels compared to wild type.

Mutant flies have reduced red pigment in the eye compared to controls.

The primary pigment cells in ca1 flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca1 flies. and bwkΔ11 produces animals with an extra veins phenotype.

Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless.

Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal.

Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine.

Produce less v+ substance than wild type.

Malpighian tubule colour: colourless.

Eye color autonomous when larval optic disk from ca1 is transplanted into wild type or v hosts. Wild-type disk in ca1 not entirely autonomous.

RK1. Eye colour: ruby. Body slightly narrow; wings pointed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

ca1 has abnormal eye color phenotype, non-enhanceable by Blos1ex2

NOT suppressed by
Statement
Reference

ca1 has abnormal eye color phenotype, non-suppressible by Blos1ex2

Enhancer of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference

ca1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

ca1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, aosGD16463

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The reduction in drosopterin pigment levels seen in flies carrying wdsRNA.GMR is enhanced manyfold if they are also mutant for ca1.

The mispatterning of the eye caused by expression of aosGD16463 under the control of Scer\GAL4GMR.PF is enhanced in a ca1 background.

The reduced red eye pigment phenotype of ca1 blos1ex2 double mutants is indistinguishable from that of ca1 single mutants.

The level of pteridine eye pigments in ltd1 ; ca1 double mutant flies resembles that seen in ca1 single mutants.

Eye colour: deep reddish yellow, with cn1. Eye colour: translucent brownish yellow, with bw1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (2)
Stocks (471)
Notes on Origin
Discoverer

Bridges, 12th Dec. 1919.

Comments
Comments

Mutant does not affect ncd function.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (36)