FlyBase Allele Report: Dmel\aos[GD16463]

General Information

Symbol

Dmel\aos^GD16463

Species

D. melanogaster

Name

FlyBase ID

FBal0209076

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

Carried in Construct

P{GD16463}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD16463}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD16463

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^GMR.PU

(Harris et al., 2011)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Harris et al., 2011)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of aos^GD16463 under the control of Scer\GAL4^GMR.PF results in a weak mispatterning of the eye surface.

(Harris et al., 2011)

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 100% of the Scer\GAL4^pnr-MD237 expression domain.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

16463

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, aos^GD16463 has visible phenotype, enhanceable by rb¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has visible phenotype, enhanceable by p¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has visible phenotype, enhanceable by ca¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has visible phenotype, enhanceable by cd^Y459X

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has visible phenotype, enhanceable by Dcr-2^UAS.cDa, Scer\GAL4^GMR.PU

(Harris et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, aos^GD16463 has eye phenotype, enhanceable by rb¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has eye phenotype, enhanceable by p¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has eye phenotype, enhanceable by ca¹

(Harris et al., 2011)

Scer\GAL4^GMR.PU, aos^GD16463 has eye phenotype, enhanceable by cd^Y459X

(Harris et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The mispatterning of the eye caused by expression of aos^GD16463 under the control of Scer\GAL4^GMR.PF is modestly enhanced in a rb¹ or p¹ mutant background and is more strongly enhanced in a ca¹ background.

The mispatterning of the eye caused by expression of aos^GD16463 under the control of Scer\GAL4^GMR.PF is enhanced in a cd^Y459X background.

The mispatterning of the eye caused by expression of aos^GD16463 under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of Dcr-2^Scer\UAS.cDa.

(Harris et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v47180