FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cdY459X
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General Information
Symbol
Dmel\cdY459X
Species
D. melanogaster
Name
FlyBase ID
FBal0265698
Feature type
allele
Associated gene
Dmel\cd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Y459term.

    (Harris et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:22,696,699..22,696,699 [+]
    Nucleotide change:

    T22696699R

    Amino acid change:

    Y459term | cd-PA

    Reported amino acid change:

    Y459term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Harris et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies show a significant reduction in ommochrome pigment levels compared to wild type.

        (Harris et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        cdY459X is an enhancer of visible phenotype of Scer\GAL4GMR.PU, aosGD16463

        (Harris et al., 2011)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        cdY459X is an enhancer of eye phenotype of Scer\GAL4GMR.PU, aosGD16463

        (Harris et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mispatterning of the eye caused by expression of aosGD16463 under the control of Scer\GAL4GMR.PF is enhanced in a cdY459X background.

        (Harris et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        cdY459X is rescued by cdUASp.EGFP/Scer\GAL4GMR.PU

        (Harris et al., 2011)

        cdY459X is rescued by cdUASp.cHa/Scer\GAL4GMR.PU

        (Harris et al., 2011)
        Comments

        Expression of cdScer\UAS.P\T.cHa or cdScer\UAS.P\T.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PF rescues the reduction in ommochrome pigment levels that is seen in cdY459X flies.

        (Harris et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        cdY459X
        (Harris et al., 2011)
        cdY495X
        (Harris et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)