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General Information
Symbol
Dmel\BxGD1385
Species
D. melanogaster
Name
FlyBase ID
FBal0198852
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-BxRNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of BxGD1385 under the control of Scer\GAL4He.PZ does not lead to any changes in the haemocyte count while its expression under the control of Scer\GAL4He.PZ or Scer\GAL4lz-gal4 leads to a decrease in crystal cell numbers when compared to control larvae.

Expression of BxGD1385 under the control of Scer\GAL4elav-C155 does not lead to any easily observable egg phenotypes when compared to controls.

Expression of BxGD1385 under the control of Scer\GAL4pnr-MD237 leads to a reduction in the number of thoracic bristles compared to controls.

Eggs laid by females expressing BxGD1385 under the control of Scer\GAL4c204 or Scer\GAL4c323a but not Scer\GAL4c306 are smaller and translucent; appear collapsed; and their dorsal appendages are thin and shorter when compared to controls.

Expression of BxGD1385 under the control of Scer\GAL4slbo.2.6 does not lead to any changes in fecundity or border cell migration in the egg chamber of females when compared to controls.

Expression of BxGD1385 in muscle under the control of Scer\GAL4Mef2.PR has no effect on female fecundity or fertility. Expression of BxGD1385 in neurons under the control of Scer\GAL4elav-C155 results in highly reduced fecundity and fertility. Unhatched eggs are white in color, indicating a defect in fertilization. Ovulation is reduced, as is sperm release from the seminal receptacle. Oviposition defects are also seen: in contrast to control flies, Scer\GAL4elav-C155>BxGD1385 females lay eggs on the surface of the media rather than in it. Mature eggs accumulate in the ovary.

Expression of BxGD1385 under the control of Scer\GAL4elav-C155, but limited to either the pupal stages or adult stages using Scer\GAL80ts.╬▒Tub84B, does not cause any reproductive defects. However, expression during both stages results in significantly reduced fecundity and fertility.

Expression of BxGD1385 in the octopaminergic neurons under the control of Scer\GAL4Tdc2.PC does not affect either the fertility or fecundity of female flies.

Expression of BxGD1385 in the glutamatergic neurons under the control of Scer\GAL4VGlut.PD results in a partial reduction in fertility without affecting fecundity. Oviposition defects are also observed.

Expression of BxGD1385 in motor neurons under the control of Scer\GAL4futsch-C380 results in a significant reduction in fertility and fecundity. Oviposition defects are also observed.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in a colour difference between the central Scer\GAL4pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 100% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 100% or 70-80% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 30-40% or 40-50% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of BxGD1385 under the control of Scer\GAL4He.PZ fully rescues the decreased haemocyte count phenotype while it partially rescues the increased crystal cell number phenotype of Bx1 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
BxGD1385
Name Synonyms
Secondary FlyBase IDs
    References (6)