FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sin3AdQ4
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General Information
Symbol
Dmel\Sin3AdQ4
Species
D. melanogaster
Name
FlyBase ID
FBal0119386
Feature type
allele
Associated gene
Dmel\Sin3A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Huntington's disease
        modeled by Hsap\HTT128Q.1-336.UAS
        (Branco et al., 2008)
        exacerbates  olivopontocerebellar atrophy
        modeled by Hsap\ATXN182Q.UAS
        (Branco et al., 2008)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Sin3AdQ4/+ flies have the normal number of dorsocentral bristles.

        (Biryukova and Heitzler, 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Sin3A[+]/Sin3AdQ4 is a suppressor of abnormal eye color phenotype of Hsap\MECP2R294X.UAS, Scer\GAL4GMR.PU

        (Cukier et al., 2008)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Sin3A[+]/Sin3AdQ4 is an enhancer of dorsocentral bristle | increased number phenotype of pnrD1

        (Biryukova and Heitzler, 2008)

        Sin3AdQ4 is an enhancer of retina phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

        (Branco et al., 2008)

        Sin3AdQ4 is an enhancer of retina phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PU

        (Branco et al., 2008)

        Sin3A[+]/Sin3AdQ4 is an enhancer of eye phenotype of Hsap\MECP2UAS.FL, Scer\GAL4GMR.PU

        (Cukier et al., 2008)

        Sin3A[+]/Sin3AdQ4 is an enhancer of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU

        (Cukier et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Sin3AdQ4/+ is an enhancer of the pnrD1/+ extra sensory organ phenotype.

        (Biryukova and Heitzler, 2008)
        Xenogenetic Interactions
        Statement
        Reference

        Sin3AdQ4 enhances the retinal phenotype seen when Hsap\HTT128Q.1-336.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

        Sin3AdQ4 enhances the retinal phenotype seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.

        (Branco et al., 2008)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Sin3dQ4
        (Branco et al., 2008)
        Sin3AdQ4
        Sin3adQ4
        (Cukier et al., 2008)
        dSin3AdQ4
        (Biryukova and Heitzler, 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)