FlyBase Allele Report: Dmel\Abd-B[Fab7-1]

General Information

Symbol

Dmel\Abd-B^Fab7-1

Species

D. melanogaster

Name

Frontabdominal-7

FlyBase ID

FBal0028656

Feature type

allele

Associated gene

Dmel\Abd-B

Associated Insertion(s)

Carried in Construct

Also Known As

FAb7¹, Fab-7¹, Fab-7, Abd-B^Fab-7

Key Links

Allele class

gain of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

gain of function allele

(Hagstrom et al., 1995, Galloni et al., 1993, Vazquez et al., 1993, Gyurkovics et al., 1990)

Mutagen

P-element activity

(Hogga and Karch, 1995)

Progenitor genotype

Abd-B^blt

(Hogga and Karch, 1995)

Cytology

Description

Deletion removes a domain boundary element and a silencer element (the iab-7 PRE).

(Hagstrom et al., 1997)

4.3kb deletion.

(Mihaly et al., 1997)

4kb deletion within the Fab-7 element removing a set of three strong and several weak DNaseI hypersensitive sites.

(Hagstrom et al., 1996)

Deletion within the Fab-7 element.

(Zhou et al., 1996)

Deletion in the region between iab-6 and iab-7.

(Hagstrom et al., 1995)

Deletion of a boundary element between the iab-6 and iab-7 regions of Abd-B. 4.3kb deletion that uncovers the insertion site of P{bluetail}.

(Hogga and Karch, 1995)

Deletion with a lesion in the Fab7 domain.

(Karch et al., 1994)

DNA from +123 to +126.5 is deleted, including three nuclease hypersensitive regions.

(Galloni et al., 1993)

Deletion within Fab7 region that resides between iab6 and iab7 regions.

(Vazquez et al., 1993)

Deletion of 4kb.

(Gyurkovics et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic | dominant

(Salvaing et al., 2008)

visible | dominant

(Sipos et al., 1998, Galloni et al., 1993)

visible | homeotic

(Gyurkovics et al., 1990)

Phenotype Manifest In

abdominal segment 6

(Lupo et al., 2001, Mihaly et al., 1997, Karch et al., 1994)

abdominal sternite 6 | male limited (with Abd-B^M2)

(Wang et al., 2011)

abdominal tergite 6 | male

(Sipos et al., 1998, Galloni et al., 1993)

abdominal tergite 6 | male (with Abd-B^{Mcp-B116:Sz:iab8-D16})

(Sipos et al., 1998)

abdominal tergite 6 | male (with Df(3R)P9)

(Sipos et al., 1998)

abdominal tergite 6 | male (with Df(3R)ul10)

(Sipos et al., 1998)

abdominal tergite 7 | male (with Df(3R)P9)

(Sipos et al., 1998)

adult abdominal segment 5 | male (with Df(3R)P9)

(Sipos et al., 1998)

adult abdominal segment 6

(Salvaing et al., 2008, Gyurkovics et al., 1990)

adult abdominal segment 7 | ectopic

(Salvaing et al., 2008)

adult abdominal segment 7 | ectopic | male limited (with Abd-B^M2)

(Wang et al., 2011)

adult abdominal segment 7 | male (with Abd-B^{Mcp-B116:Sz:iab8-D16})

(Sipos et al., 1998)

parasegment 11

(Hagstrom et al., 1997, Hagstrom et al., 1996, Hogga and Karch, 1995)

parasegment 11 | embryonic stage

(Vazquez et al., 1993)

parasegment 12 | embryonic stage

(Vazquez et al., 1993)

Detailed Description

Statement

Reference

An A7-like terminal abdominal segment (similar to abdominal segment 7 found in wild-type females) forms and A6 sternite is transformed toward anterior identity in Abd-B^Fab7-1/Abd-B^M2 trans-heterozygous males.

(Wang et al., 2011)

Abd-B^Fab7-1/+ males undergo an A6 to A7 transformation, resulting in a half-reduced A6 segment.

(Salvaing et al., 2008)

Heterozygous males have a rudimentary A6 segment.

(Lupo et al., 2001)

Heterozygous males show a reduction in size of the sixth abdominal tergite to the size of the seventh abdominal tergite in Abd-B^Sz/+ males. Abd-B^Sz/Abd-B^Fab7-1 males show a reduction in size of both the sixth and seventh abdominal tergites to the size of the seventh abdominal tergite in Abd-B^Sz/+ males. Abd-B^Fab7-1/Df(3R)P9 males have A6 and A7 tergites similar to those of Abd-B^Sz/Abd-B^Fab7-1 males, and also show partial transformation of segment A5 into A4. Abd-B^iab8-D16/Abd-B^Fab7-1 males show a reduction in size of the seventh abdominal tergite to the size of the seventh abdominal tergite in Abd-B^Sz/+ males, however, the sixth abdominal tergite is larger in Abd-B^iab8-D16/Abd-B^Fab7-1 males than in Abd-B^Sz/+ males and more closely resembles wild-type. The phenotype of abdominal segment 6 is similar in Abd-B^Fab7-1/Abd-B^D18, Abd-B^Fab7-1/Df(3R)ul10 and Abd-B^Fab7-1/+ flies.

(Sipos et al., 1998)

Transforms PS11 to PS12.

(Hagstrom et al., 1997)

Homozygotes show complete transformation of abdominal segment A6 to A7.

(Mihaly et al., 1997)

Transforms parasegment 11 to parasegment 12 identity.

(Hagstrom et al., 1996)

Transformation of parasegment 11 to 12.

(Hogga and Karch, 1995)

Transformation of abdominal segment 6 to A7 identity.

(Karch et al., 1994)

A6 is completely transformed into A7 in homozygotes.

(Galloni et al., 1993)

Duplication of parasegment 12-like Abd-B expression in parasegment 11.

(Vazquez et al., 1993)

Transforms A6 into A7. Larval phenotype suggests the effect is parasegmental. Misregulates Abd-B by ectopic activation of the parasegment 12 specific function in parasegment 11.

(Gyurkovics et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Abd-B^Fab7-1 has homeotic | dominant phenotype, enhanceable by Scer\GAL4^da.G32/CycG^RNAi.UAS

(Salvaing et al., 2008)

Abd-B^Fab7-1 has homeotic | dominant phenotype, enhanceable by Scer\GAL4^da.G32/CycG^UAS.cSa

(Salvaing et al., 2008)

Abd-B^Fab7-1 has homeotic | dominant phenotype, enhanceable by corto^07128b/corto[+]/CycG^UAS.cSa/Scer\GAL4^NP3121

(Salvaing et al., 2008)

Abd-B^Fab7-1 has homeotic | dominant phenotype, enhanceable by corto[+]/corto⁴²⁰

(Salvaing et al., 2008)

Abd-B^Fab7-1 has homeotic | dominant phenotype, enhanceable by corto^07128b/corto[+]

(Salvaing et al., 2008)

Suppressor of

Statement

Reference

Abd-B^Fab7-1/Abd-B^Fab7-1 is a suppressor | partially of visible | recessive phenotype of brk^Mcp

(Kyrchanova and Georgiev, 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by Scer\GAL4^da.G32/CycG^UAS.cSa

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 7 | ectopic phenotype, enhanceable by Scer\GAL4^da.G32/CycG^UAS.cSa

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto^07128b/corto[+]/CycG^UAS.cSa/Scer\GAL4^NP3121

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 7 | ectopic phenotype, enhanceable by corto^07128b/corto[+]/CycG^UAS.cSa/Scer\GAL4^NP3121

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto[+]/corto⁴²⁰

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 7 | ectopic phenotype, enhanceable by corto[+]/corto⁴²⁰

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by corto^07128b/corto[+]

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 7 | ectopic phenotype, enhanceable by corto^07128b/corto[+]

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 6 phenotype, enhanceable by Scer\GAL4^da.G32/CycG^RNAi.UAS

(Salvaing et al., 2008)

Abd-B^Fab7-1 has adult abdominal segment 7 | ectopic phenotype, enhanceable by Scer\GAL4^da.G32/CycG^RNAi.UAS

(Salvaing et al., 2008)

NOT Enhanced by

Statement

Reference

Abd-B^Fab7-1 has abdominal segment 6 phenotype, non-enhanceable by barr[+]/barr^L305

(Lupo et al., 2001)

NOT suppressed by

Statement

Reference

Abd-B^Fab7-1 has abdominal segment 6 phenotype, non-suppressible by barr[+]/barr^L305

(Lupo et al., 2001)

NOT Enhancer of

Statement

Reference

Abd-B^Fab7-1/Abd-B[+] is a non-enhancer of abdominal segment 6 phenotype of barr^L305

(Lupo et al., 2001)

Suppressor of

Statement

Reference

Abd-B^Fab7-1/Abd-B^Fab7-1 is a suppressor | partially of wing phenotype of brk^Mcp

(Kyrchanova and Georgiev, 2010)

NOT Suppressor of

Statement

Reference

Abd-B^Fab7-1/Abd-B[+] is a non-suppressor of abdominal segment 6 phenotype of barr^L305

(Lupo et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The penetrance of the wing defect phenotype caused by brk^Mcp is decreased to 14.5% if the animals are also homozygous for Abd-B^Fab7-1.

(Kyrchanova and Georgiev, 2010)

One copy of corto⁴²⁰ enhances the expressivity of the A6-A7 transformation seen in Abd-B^Fab7-1/+ males. The A6 segment has completely disappeared in 100% of male flies.

One copy of corto^07128b enhances the expressivity of the A6-A7 transformation seen in Abd-B^Fab7-1/+ males. The A6 segment has completely disappeared in 100% of male flies.

Expression of CycG^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 slightly enhances the homeotic transformation from A7 to A6 seen in Abd-B^Fab7-1 male heterozygotes. The expressivity is slightly enhanced in 86% of flies but at least a thin A6 segment always persists. No cuticular defects are seen in either abdominal segment A5 or the remaining A6 tergites.

Expression of CycG^Scer\UAS.cSa under the control of Scer\GAL4^da.G32 slightly enhances the homeotic transformation from A7 to A6 seen in Abd-B^Fab7-1 male heterozygotes. The A6 segment has completely disappeared in 56% of flies. 100% of males completely lack A6 when CycG^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Act.NP3121.

Expression of CycG^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act.NP3121 and one copy of corto^07128b enhance the A7 to A6 homeotic transformation seen in the few Abd-B^Fab7-1/+ male escapers.

(Salvaing et al., 2008)

The addition of barr^L305/+ has no effect on the abdominal segment phenotype of Abd-B^Fab7-1/+.

(Lupo et al., 2001)

The heterozygous gain of function phenotype is unchanged in a Polycomb group mutant background.

(Mihaly et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: Fab-7¹.

Comments

Deletion removes all three prominent nuclear hypersensitive sites, plus most of the minor sites.

(Karch et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Abd-B^Fab-7

(Wang and Yoder, 2012, Wang et al., 2011)

Abd-B^Fab7-1

(Foronda et al., 2012)

Abd-B^Fab7

FAb7¹

(Hagstrom et al., 1997)

Fab

(Mack et al., 1997)

Fab-7

(Sipos et al., 1998, Hagstrom et al., 1995, Hendrickson and Sakonju, 1995, Hogga and Karch, 1995, Gyurkovics et al., 1990)

Fab-7¹

(Singh and Mishra, 2015, Bantignies et al., 2011, Maeda and Karch, 2006, Brown et al., 2003, Mihaly et al., 1997, Hagstrom et al., 1996, Zhou et al., 1996, Hogga and Karch, 1995)

Fab7¹

(Gummalla et al., 2012, Kyrchanova and Georgiev, 2010, Kyrchanova and Georgiev, 2010, Salvaing et al., 2008, Rank et al., 2002, McCall and Bender, 1996, Karch et al., 1994, Galloni et al., 1993, Vazquez et al., 1993)

abd-B^Fab-7

(Wang et al., 2013)

Name Synonyms

Frontabdominal-7

(Gyurkovics et al., 1990)

Secondary FlyBase IDs

FBal0028659

References (28)

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