FlyBase Allele Report: Dmel\osa[616]

General Information

Symbol

Dmel\osa⁶¹⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0062860

Feature type

allele

Associated gene

Dmel\osa

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Treisman et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q338term.

(Treisman et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:17,708,251..17,708,251 [-]

Nucleotide change:

C17708251T

Amino acid change:

Reported amino acid change:

Q338term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Treisman et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Chanut et al., 2000)

some die during embryonic stage | recessive

(Chanut et al., 2000)

visible | dominant

(Chanut et al., 2000)

Phenotype Manifest In

dorsocentral bristle | increased number

(Heitzler et al., 2003)

eye | somatic clone

(Chanut et al., 2000)

mesonotum | somatic clone

(Treisman et al., 1997)

retina | somatic clone

(Chanut et al., 2000)

wing

(Chanut et al., 2000)

wing & macrochaeta

(Treisman et al., 1997)

wing | ectopic

(Treisman et al., 1997)

wing blade anterior compartment | dorsal | somatic clone

(Treisman et al., 1997)

wing disc

(Treisman et al., 1997)

wing margin bristle | ectopic

(Treisman et al., 1997)

Detailed Description

Statement

Reference

Hemizygous mutant adults exhibit about 2.38 dorsocentral bristle per heminotum (compared to 2.00 in wild-type).

(Heitzler et al., 2003)

Dominant held out wing phenotype. Clones lead to scars and loss of retinal differentiation.

(Chanut et al., 2000)

Clones induced on the wing disc produced early in development transforms the posterior notum into a partial second wing. The wings have reversed anterior-posterior polarity. Clones induced later in development are associated with ectopic wing margin bristles near the wing margin restricted to the dorsal surface of the anterior compartment.

(Treisman et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

osa[+]/osa⁶¹⁶ is a suppressor of visible phenotype of ro^DOM

(Chanut et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

osa⁶¹⁶ is an enhancer of dorsocentral bristle | increased number phenotype of pnr^D1

(Heitzler et al., 2003)

osa⁶¹⁶ is an enhancer of thorax phenotype of Chi^E

(Heitzler et al., 2003)

Suppressor of

Statement

Reference

osa⁶¹⁶ is a suppressor of dorsocentral bristle phenotype of tou²

(Vanolst et al., 2005)

osa⁶¹⁶ is a suppressor of dorsocentral bristle phenotype of Chi^E

(Heitzler et al., 2003)

osa[+]/osa⁶¹⁶ is a suppressor of eye phenotype of ro^DOM

(Chanut et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

tou² ; osa⁶¹⁶/+ flies exhibit an average of 1.97 dorsocentral bristles per heminotum, compared to 1.4 in tou²/+ flies and 2.0 in wild-type controls.

(Vanolst et al., 2005)

Strong suppressor of ro^DOM.

(Chanut et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

eld⁶¹⁶

osa⁶¹⁶

osa^eld616

(Collins and Treisman, 2000)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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