Makarova, K.S., Aravind, L., Koonin, E.V. (2002). SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes.  Trends Biochem. Sci. 27(8): 384--386.

FBrf0183153

Review

A previously undetected domain with a CxCx(n)CxH pattern of predicted zinc-chelating residues was identified in a variety of prokaryotic and eukaryotic proteins. These include bacterial ATPases of the SWI2/SNF2 family, plant MuDR transposases and transposase-derived Far1 nuclear proteins, and vertebrate MEK kinase-1. This domain was designated SWIM after SWI2/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts.