FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

target-directed miRNA degradation

ID (Ontology)

GO:0140958 (Gene Ontology)

Definition

The process in which a miRNA is targeted for degradation by a non-coding RNA or mRNA. The binding of an RNA to a target miRNA within a RISC complex results in either ubiquitin-mediated degradation of AGO protein or the displacement of the 3' end of the miRNA, exposing it to nucleases.[ PubMed:33184237 PubMed:36150386 ]

Also Known As

"target-directed microRNA degradation" ; "TDMD"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
target-directed miRNA degradation (all annotations which use CV term, excluding "NOT" statements)
acts_upstream_of_positive_effect \| target-directed miRNA degradation
involved_in \| target-directed miRNA degradation

Spanning Tree (Parents/Children)

RNA catabolic process
 |__miRNA catabolic process_____________________________________________________
miRNA metabolic process                                                         |
 |__miRNA catabolic process_____________________________________________________|
post-transcriptional regulation of gene expression                              |
 |__post-transcriptional gene silencing_________________________________________|
negative regulation of gene expression                                          |
 |__post-transcriptional gene silencing_________________________________________|
regulation of miRNA-mediated gene silencing                                     |
 |__negative regulation of miRNA-mediated gene silencing________________________|
negative regulation of post-transcriptional gene silencing by regulatory ncRNA  |
 |__negative regulation of miRNA-mediated gene silencing________________________|
                                                                                target-directed miRNA degradation  6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	miRNA catabolic process post-transcriptional gene silencing negative regulation of miRNA-mediated gene silencing
Part of
Synonyms & Secondary IDs
Synonyms
	"target-directed microRNA degradation" EXACT "TDMD" EXACT
Secondary IDs

External Crossreferences & Linkouts