FB2022_03, released June 9, 2022

Gene: Dmel\wgn

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General Information
Symbol
Dmel\wgn
Species
D. melanogaster
Name
wengen
Annotation Symbol
CG6531
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030941
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
wengen (wgn) encodes a receptor for tumor necrosis factor (TNF) ligands, such as the product of egr. Signalling by this receptor is involved in apoptosis, photoreceptor axon guidance and nutritional control of body size. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

TNFR

Key Links
Genomic Location
Cytogenetic map
17C5-17C6
Sequence location
Recombination map
1-60
RefSeq locus
NC_004354 REGION:18624042..18634908
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9W3I9
(assigned by UniProt )
(Moreno et al., 2002)
inferred from physical interaction with FLYBASE:egr; FB:FBgn0033483
(Kanda et al., 2002)
enables tumor necrosis factor receptor activity
inferred from mutant phenotype
(assigned by UniProt )
(Moreno et al., 2002)
inferred from direct assay
(Palmerini et al., 2021, Kanda et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from direct assay
(assigned by UniProt )
(Moreno et al., 2002)
involved_in negative regulation of neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:Ank2; FB:FBgn0261788
(Keller et al., 2011)
involved_in neuron cellular homeostasis
inferred from genetic interaction with FLYBASE:Ank2; FB:FBgn0261788
(Keller et al., 2011)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Ruan et al., 2013)
acts_upstream_of positive regulation of cell death
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Kanda et al., 2002)
involved_in tumor necrosis factor-mediated signaling pathway
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Kauppila et al., 2003, Kanda et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cell surface
inferred from direct assay
(assigned by UniProt )
(Moreno et al., 2002)
located_in integral component of plasma membrane
inferred from direct assay
(Kanda et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from sequence or structural similarity with HGNC:11916
(Kanda et al., 2002)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
wengen (wgn) encodes a receptor for tumor necrosis factor (TNF) ligands, such as the product of egr. Signalling by this receptor is involved in apoptosis, photoreceptor axon guidance and nutritional control of body size. [Date last reviewed: 2019-03-21]
Pathway (FlyBase)
TNFα-Eiger Signaling Pathway Core Components -
The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)
Gene Group (FlyBase)
TUMOR NECROSIS FACTOR RECEPTORS -
The tumor necrosis factor receptors (TNFRs) are type I transmembrane proteins that bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. (Adapted from FBrf0162270.)
Protein Function (UniProtKB)
Receptor for egr (PubMed:12084706, PubMed:12894227). Involved in induction of apoptosis by triggering JNK signaling (PubMed:12894227). Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity (PubMed:19289090). Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious (PubMed:19375319). Together with Moe, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124).
(UniProt, Q9VWS4)
Summary (Interactive Fly)

tumor necrosis factor receptor superfamily - forced expression triggers cell death - nociceptive sensitization

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\wgn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VWS4)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
wgn-RA
FBtr0074617
NM_167626
2415
343
wgn-RB
FBtr0342843
NM_001298481
2594
267
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
wgn-PA
FBpp0074388
37.8
343
8.58
Q9VWS4
NP_728186
AAF48864
wgn-PB
FBpp0309667
30.2
267
8.84
X2JCG6
NP_001285410
AHN59880
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with egr (PubMed:12084706). Interacts with Traf6 (PubMed:12894227). Interacts with Moe (PubMed:23544124).

(UniProt, Q9VWS4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wgn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 6 -- 8
mesoderm
(Kauppila et al., 2003)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 12
mesoderm | segmentally repeated
(Kauppila et al., 2003)
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
tracheal dorsal trunk primordium

Comment: reported as dorsal trunk specific anlage

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
pericardial cell primordium

Comment: reported as pericardial cell specific anlage

(Fisher et al., 2012)
primary segmental tracheal branch primordium

Comment: reported as primary segmental branch specific anlage

(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
circular visceral muscle fiber
(Fisher et al., 2012)
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic/larval dorsal tracheal branch
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval pericardial cell
(Fisher et al., 2012)
embryonic/larval visceral muscle cell
(Fisher et al., 2012)
labral segment
(Fisher et al., 2012)
embryonic stage 15 -- 16
larval ventral nerve cord | restricted
(Kauppila et al., 2003)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
motor neuron of embryonic/larval brain
(Keller et al., 2011)
Additional Descriptive Data

wgn transcript is undetectable prior to gastrulation. During germ band extension, wgn is expressed in the mesoderm, apposed the expression of egr in the neurogenic region. At embryonic stage 15-16, wgn is expressed in a subset of cells in the condensing nerve cord.

(Kauppila et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
photoreceptor neuron
(Ruan et al., 2013)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye

Comment: Eye and brain were assayed together.

(Ruan et al., 2013)
embryonic/larval brain

Comment: Eye and brain were assayed together.

(Ruan et al., 2013)
adult stage
adult head
(Ruan et al., 2013)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell surface
inferred from direct assay
(assigned by UniProt )
(Moreno et al., 2002)
located_in integral component of plasma membrane
inferred from direct assay
(Kanda et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\wgn in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of wgn
Transgenic constructs containing regulatory region of wgn
Aberrations (Deficiencies and Duplications) ( 1 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal - majority die | nutrition conditional, with Scer\GAL4Tub.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4GMR.PF
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4sca-109-68
majority die during P-stage | nutrition conditional, with Scer\GAL4Tub.PU
Phenotype manifest in
Allele
lamina | third instar larval stage
lamina plexus | third instar larval stage
lamina plexus | third instar larval stage, with Scer\GAL4GMR.PF
medulla | third instar larval stage
medulla | third instar larval stage, with Scer\GAL4GMR.PF
photoreceptor cell R2 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R2 | third instar larval stage
photoreceptor cell R3 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R3 | third instar larval stage
photoreceptor cell R4 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R4 | third instar larval stage
photoreceptor cell R5 | cell non-autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R5 | third instar larval stage
photoreceptor cell R8 | cell autonomous | third instar larval stage, with Scer\GAL4sca-109-68
photoreceptor cell R8 | somatic clone | third instar larval stage
photoreceptor cell R8 | third instar larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NGFR
1 of 15
Yes
Yes
Hsap\TNFRSF4
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ngfr
1 of 15
Yes
Yes
Mmus\Tnfrsf4
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Ngfr
1 of 13
Yes
Yes
Rnor\Tnfrsf4
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ngfr
1 of 12
Yes
Yes
Xtro\nradd
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\ngfra
1 of 15
Yes
Yes
Drer\ngfrb
1 of 15
Yes
Yes
Drer\nradd
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    wgn
    enhanceable
    Moe
    (Ruan et al., 2013)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Ank2
    suppressible
    wgn
    (Keller et al., 2011)
    egr
    suppressible
    wgn
    (Kanda et al., 2002)
    Ras85D
    suppressible
    wgn
    (Wu et al., 2009)
    Ras85D|l(2)gl
    suppressible
    wgn
    (Igaki et al., 2006)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with egr (PubMed:12084706). Interacts with Traf6 (PubMed:12894227). Interacts with Moe (PubMed:23544124).
    (UniProt, Q9VWS4 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    TNFα-Eiger Signaling Pathway Core Components -
    The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-60
    Cytogenetic map
    17C5-17C6
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    17C5-17C6
    Limits computationally determined from genome sequence between P{EP}EP443EP443&P{EP}BxEP1383 and P{EP}Pk17EEP438
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-60

    (FlyBase, 2016)

    1-59.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (51)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Ruan et al., 2013)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: wgn CG6531

    (FlyBase, 1996-)
    Source for database merge of
    Additional comments

    Source for identity of wgn CG6531 was sequence comparison ( date:020710 ).

    (FlyBase, 1996-)
    Other Comments
    Origin and Etymology
    Discoverer
    Etymology

    The gene is named "wengen" for a village at the foot of Mt. Eiger.

    (Kanda et al., 2002)
    Identification
    External Crossreferences and Linkouts ( 47 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL - MARRVEL (model organism gene)
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (9)
    Reported As
    Symbol Synonym
    CG6531
    (Metwally et al., 2019, Meadows, 2017.1.11, Ghimire and Kim, 2015, Ni et al., 2010.12.1, Fujikawa et al., 2009)
    TNFR
    (Baker, 2020, Baker, 2017, O'Keefe et al., 2015, Pastor-Pareja and Xu, 2013, Kato et al., 2011, Keller et al., 2011)
    Wengen
    (Millet-Boureima et al., 2021, Nagai et al., 2021, Khuong and Neely, 2013)
    Wgn
    (Dillard et al., 2021, Herrera and Bach, 2021, La Marca and Richardson, 2020, Metwally et al., 2019, de Vreede et al., 2018, Chabu and Xu, 2014, Ma et al., 2014)
    Wng
    (Palmerini et al., 2021)
    vader
    (Chaudhary, 2002.5.28)
    wengen
    (O'Keefe et al., 2015)
    wgn
    (Havula et al., 2022, Buhlman et al., 2021, Everetts et al., 2021, Hodgson et al., 2021, Palmerini et al., 2021, Snigdha et al., 2021, Ai et al., 2020, Muliyil et al., 2020, Nakajima et al., 2020, Chang et al., 2019, Xu et al., 2019, Paul et al., 2018, Muzzopappa et al., 2017, Agrawal et al., 2016, Fogarty et al., 2016, Sarov et al., 2016, Andersen et al., 2015, Stronach, 2015.1.9, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Jin et al., 2013, Ruan et al., 2013, Webber et al., 2013, Kelsey et al., 2012, Kato et al., 2011, Keller et al., 2011, Neisch et al., 2010, Ejsmont et al., 2009, Fujikawa et al., 2009, Xue et al., 2007, Zeitlinger et al., 2007, Alekseyenko et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jacobsen et al., 2006)
    Name Synonyms
    TNF-α receptor
    (Keller et al., 2011)
    Wengen
    (Bittern et al., 2021, Harnish et al., 2021, Hounsell and Fan, 2021, Mishra et al., 2021, Sharma et al., 2021, Jackson et al., 2020, Mirzoyan et al., 2019, Ahmed-de-Prado and Baonza, 2018, Eroglu and Derry, 2016, Schimizzi et al., 2016, Chabu and Xu, 2014, Ríos-Barrera and Riesgo-Escovar, 2013, Tang et al., 2013, Kanda et al., 2011, Neisch et al., 2010, Wu et al., 2009, Lhocine et al., 2008, Kuranaga and Miura, 2007, Igaki et al., 2006, Leclerc and Reichhart, 2004, Kauppila et al., 2003)
    wengen
    (Artiushin and Sehgal, 2020, Muliyil et al., 2020, Zhu et al., 2019, Paul et al., 2018, Fogarty et al., 2016, Andersen et al., 2015, Ghimire and Kim, 2015, Kuang et al., 2014, Marchal et al., 2012, Juarez et al., 2011, Keller et al., 2011, Babcock and Galko, 2009, Babcock et al., 2009, Igaki et al., 2006, Kanda, 2002.5.23)
    Secondary FlyBase IDs
    • FBgn0062834
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    References (115)