FlyBase Gene Report: Dmel\Ank

General Information

Symbol

Dmel\Ank

Species

D. melanogaster

Name

Ankyrin

Annotation Symbol

CG1651

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011747

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Ankyrin (Ank) encodes protein that is recruited to the plasma membrane by its association with the product of β-Spec. It also binds to the adhesion protein encoded by Nrg leading to accumulation of the products of Ank and β-Spec at sites of cell-cell adhesion. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Dank1

Key Links

Genomic Location

Cytogenetic map

102A3-102A3

Sequence location

4:115,074..129,849 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:115074..129849

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables cytoskeletal anchor activity

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

enables spectrin binding

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

enables transmembrane transporter binding

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein localization to plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000488

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

inferred from direct assay

(Das et al., 2006, Dubreuil et al., 1997)

located_in spectrosome

inferred from direct assay

(de Cuevas et al., 1996)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002380879

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ank for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0KIE7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ank-RB

FBtr0089173

NM_175926

5101

1549

Ank-RC

FBtr0089171

NM_175927

5176

1549

Ank-RD

FBtr0089172

NM_175928

5291

1549

Ank-RE

FBtr0300497

NM_001169348

5777

1549

Additional Transcript Data and Comments

Reported size (kB)

5.5 (northern blot)

(Dubreuil and Yu, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ank-PB

FBpp0088240

170.2

1549

7.05

FBpp0088238

170.2

1549

7.05

FBpp0088239

170.2

1549

7.05

FBpp0289724

170.2

1549

7.05

Q0KIE7

NP_001162819

ACZ95088

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1549 aa isoforms: Ank-PB, Ank-PC, Ank-PD, Ank-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

1549 (aa); 170 (kD observed); 170 (kD predicted)

(Dubreuil and Yu, 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ank using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ank_1
Ank_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.88

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Bouley et al., 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Dubreuil and Yu, 1994)

embryonic stage -- adult stage

organism

(Bouley et al., 2000)

oogenesis & adult stage | female

ovary

(Dubreuil and Yu, 1994)

S2 cell-line

(Bouley et al., 2000)

Additional Descriptive Data

Ank transcripts are detected in RNA from ovaries and embryos.

(Dubreuil and Yu, 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

salivary gland

• plasma membrane

(Dubreuil et al., 1997)

adult stage & oogenesis

follicle cell

(Dubreuil et al., 1997)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Bouley et al., 2000)

embryonic stage 14

salivary gland body primordium

(Bouley et al., 2000)

oogenesis

spectrosome of germline stem cell

(de Cuevas et al., 1996)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

• membrane

(Bouley et al., 2000)

embryonic stage & larval stage & adult stage

(Dubreuil and Yu, 1994)

Additional Descriptive Data

Ank protein is associated with the plasma membrane in S2 cell aggregates expressing Nrg.

(Dubreuil et al., 1997, Dubreuil and Yu, 1994)

Ank is expressed at the lateral cell contacts of follicle cells in the ovary.

(Dubreuil et al., 1997)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

inferred from direct assay

(Das et al., 2006, Dubreuil et al., 1997)

located_in spectrosome

inferred from direct assay

(de Cuevas et al., 1996)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ank in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ank

View exonic expression by tissue for Dmel\Ank

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43770/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011747

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011747

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011747

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1651

Flygut - An atlas of the Drosophila adult midgut

FBgn0011747

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ank

Transgenic constructs containing regulatory region of Ank

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(4)M101-62f

(Podemski et al., 2004)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

Ank^GD10431

viable, with Scer\GAL4^pnr-MD237

Ank^GD10431

viable, with Scer\GAL4^tin.CΔ4

Ank^GD10431

Sterility

Allele

female fertile

Ank^A

female fertile (with Df(4)ED6366)

Ank^A

Phenotype manifest in

Allele

ovariole

Ank^MB02705

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (127)

Hsap\ANK1

11 of 14

Yes

Hsap\ANK3

10 of 14

Yes

Hsap\ANK2

8 of 14

Yes

Hsap\ANKRD44

3 of 14

Hsap\ANKDD1A

2 of 14

Yes

Hsap\ANKDD1B

2 of 14

Yes

Hsap\ANKEF1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\ANKRD60

2 of 14

Yes

Hsap\ASB7

2 of 14

Yes

Hsap\PIDD1

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ANKMY2

1 of 14

Hsap\ANKRD1

1 of 14

Yes

Hsap\ANKRD6

1 of 14

Hsap\ANKRD10

1 of 14

Yes

Hsap\ANKRD16

1 of 14

Hsap\ANKRD17

1 of 14

Hsap\ANKRD20A1

1 of 14

Yes

Hsap\ANKRD20A2P

1 of 14

Yes

Hsap\ANKRD20A3P

1 of 14

Yes

Hsap\ANKRD20A4P

1 of 14

Yes

Hsap\ANKRD20A8P

1 of 14

Yes

Hsap\ANKRD26

1 of 14

Yes

Hsap\ANKRD27

1 of 14

Hsap\ANKRD29

1 of 14

Hsap\ANKRD34A

1 of 14

Yes

Hsap\ANKRD34B

1 of 14

Yes

Hsap\ANKRD34C

1 of 14

Yes

Hsap\ANKRD35

1 of 14

Yes

Hsap\ANKRD36C

1 of 14

Yes

Hsap\ANKRD40

1 of 14

Yes

Hsap\ANKRD42

1 of 14

Hsap\ANKRD45

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ASB2

1 of 14

Yes

Hsap\ASB3

1 of 14

Yes

Hsap\ASB4

1 of 14

Yes

Hsap\ASB5

1 of 14

Yes

Hsap\ASB8

1 of 14

Yes

Hsap\ASB9

1 of 14

Yes

Hsap\ASB10

1 of 14

Hsap\ASB11

1 of 14

Yes

Hsap\ASB13

1 of 14

Yes

Hsap\ASB14

1 of 14

Yes

Hsap\ASB15

1 of 14

Yes

Hsap\ASB16

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DAPK1

1 of 14

Hsap\DTHD1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\HACE1

1 of 14

Hsap\HSPA5

1 of 14

Hsap\INVS

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\NFKBIE

1 of 14

Hsap\NFKBIZ

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (107)

Rnor\Ank1

9 of 14

Yes

Rnor\Ank3

9 of 14

Yes

Rnor\Ank2

8 of 14

Yes

Rnor\Ankdd1a

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Asb3

2 of 14

Yes

Rnor\Asb7

2 of 14

Yes

Rnor\Pidd1

2 of 14

Yes

Rnor\Tnks

2 of 14

Rnor\Ankef1

1 of 14

Yes

Rnor\Ankfy1

1 of 14

Rnor\Ankhd1

1 of 14

Rnor\Ankk1

1 of 14

Yes

Rnor\Ankmy1

1 of 14

Yes

Rnor\Ankmy2

1 of 14

Rnor\Ankrd1

1 of 14

Yes

Rnor\Ankrd6

1 of 14

Rnor\Ankrd10

1 of 14

Yes

Rnor\Ankrd17

1 of 14

Rnor\Ankrd27

1 of 14

Yes

Rnor\Ankrd34a

1 of 14

Yes

Rnor\Ankrd34b

1 of 14

Yes

Rnor\Ankrd34c

1 of 14

Yes

Rnor\Ankrd35

1 of 14

Yes

Rnor\Ankrd37

1 of 14

Yes

Rnor\Ankrd40

1 of 14

Yes

Rnor\Ankrd46

1 of 14

Yes

Rnor\Ankrd53

1 of 14

Yes

Rnor\Ankrd54

1 of 14

Rnor\Ankrd61

1 of 14

Rnor\Ankrd66

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Asb2

1 of 14

Yes

Rnor\Asb4

1 of 14

Yes

Rnor\Asb5

1 of 14

Yes

Rnor\Asb8

1 of 14

Yes

Rnor\Asb9

1 of 14

Yes

Rnor\Asb10

1 of 14

Yes

Rnor\Asb11

1 of 14

Yes

Rnor\Asb12

1 of 14

Rnor\Asb13

1 of 14

Yes

Rnor\Asb14

1 of 14

Yes

Rnor\Asb15

1 of 14

Yes

Rnor\Asb16

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Nfkbie

1 of 14

Rnor\Nfkbiz

1 of 14

Yes

Rnor\Osbpl1a

1 of 14

Rnor\Pla2g6

1 of 14

Rnor\Pnpla8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ripk2

1 of 14

Rnor\Ripk4

1 of 14

Rnor\Slc9c2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (109)

Mmus\Ank1

10 of 14

Yes

Mmus\Ank3

9 of 14

Yes

Mmus\Ank2

7 of 14

Yes

Mmus\Ankrd44

3 of 14

Yes

Mmus\Ankdd1b

2 of 14

Yes

Mmus\Ankef1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Asb7

2 of 14

Yes

Mmus\Pidd1

2 of 14

Yes

Mmus\Rnasel

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ankmy2

1 of 14

Mmus\Ankrd1

1 of 14

Yes

Mmus\Ankrd6

1 of 14

Mmus\Ankrd7

1 of 14

Yes

Mmus\Ankrd10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ankrd34b

1 of 14

Yes

Mmus\Ankrd34c

1 of 14

Yes

Mmus\Ankrd35

1 of 14

Yes

Mmus\Ankrd37

1 of 14

Yes

Mmus\Ankrd40

1 of 14

Yes

Mmus\Ankrd45

1 of 14

Yes

Mmus\Ankrd46

1 of 14

Yes

Mmus\Ankrd50

1 of 14

Mmus\Ankrd54

1 of 14

Mmus\Ankrd60

1 of 14

Yes

Mmus\Ankrd61

1 of 14

Mmus\Ankrd65

1 of 14

Mmus\Ankrd66

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Asb2

1 of 14

Mmus\Asb3

1 of 14

Mmus\Asb4

1 of 14

Yes

Mmus\Asb5

1 of 14

Yes

Mmus\Asb8

1 of 14

Yes

Mmus\Asb9

1 of 14

Yes

Mmus\Asb10

1 of 14

Mmus\Asb11

1 of 14

Yes

Mmus\Asb13

1 of 14

Yes

Mmus\Asb14

1 of 14

Mmus\Asb15

1 of 14

Mmus\Asb16

1 of 14

Yes

Mmus\Asb18

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Nfkbie

1 of 14

Mmus\Nfkbiz

1 of 14

Yes

Mmus\Osbpl1a

1 of 14

Mmus\Pla2g6

1 of 14

Mmus\Pnpla8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (74)

Xtro\ank2

6 of 13

Yes

Xtro\ank1

5 of 13

Yes

Xtro\ank3

5 of 13

Yes

Xtro\noct

4 of 13

Xtro\asb14

2 of 13

Yes

Xtro\LOC100497775

2 of 13

Yes

Xtro\ankdd1a

1 of 13

Yes

Xtro\ankdd1b

1 of 13

Yes

Xtro\ankmy1

1 of 13

Yes

Xtro\ankmy2

1 of 13

Xtro\ankrd1

1 of 13

Yes

Xtro\ankrd6

1 of 13

Yes

Xtro\ankrd10

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ankrd28

1 of 13

Xtro\ankrd34a

1 of 13

Yes

Xtro\ankrd40

1 of 13

Yes

Xtro\ankrd42

1 of 13

Xtro\ankrd50

1 of 13

Xtro\ankrd53

1 of 13

Yes

Xtro\ankrd54

1 of 13

Xtro\ankrd60

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\asb9

1 of 13

Yes

Xtro\asb16

1 of 13

Yes

Xtro\asb18

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\kidins220

1 of 13

Xtro\klhl17

1 of 13

Xtro\krit1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pnpla8

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ripk2

1 of 13

Yes

Xtro\ripk4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (117)

Drer\ank1b

9 of 14

Yes

Drer\ank3a

9 of 14

Yes

Drer\ank1a

8 of 14

Yes

Drer\ank2a

8 of 14

Yes

Drer\ank2b

8 of 14

Yes

Drer\caiap

4 of 14

Drer\ank3b

2 of 14

Yes

Drer\ankar

2 of 14

Yes

Drer\ankdd1b

2 of 14

Yes

Drer\ankef1a

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\tnksa

2 of 14

Drer\tnksb

2 of 14

Drer\ankef1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ankmy2a

1 of 14

Drer\ankmy2b

1 of 14

Drer\ankrd1a

1 of 14

Yes

Drer\ankrd1b

1 of 14

Yes

Drer\ankrd6b

1 of 14

Drer\ankrd10a

1 of 14

Yes

Drer\ankrd10b

1 of 14

Yes

Drer\ankrd16

1 of 14

Yes

Drer\ankrd27

1 of 14

Yes

Drer\ankrd31

1 of 14

Yes

Drer\ankrd34ba

1 of 14

Yes

Drer\ankrd34bb

1 of 14

Yes

Drer\ankrd34c

1 of 14

Yes

Drer\ankrd40

1 of 14

Yes

Drer\ankrd45

1 of 14

Yes

Drer\ankrd53

1 of 14

Drer\ankrd54

1 of 14

Drer\ankrd67

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\asb2a.1

1 of 14

Yes

Drer\asb2b

1 of 14

Yes

Drer\asb3

1 of 14

Yes

Drer\asb4

1 of 14

Yes

Drer\asb5a

1 of 14

Yes

Drer\asb5b

1 of 14

Yes

Drer\asb7

1 of 14

Drer\asb8

1 of 14

Yes

Drer\asb10

1 of 14

Yes

Drer\asb11

1 of 14

Yes

Drer\asb13a.1

1 of 14

Yes

Drer\asb13a.2

1 of 14

Yes

Drer\asb13b

1 of 14

Yes

Drer\asb14a

1 of 14

Yes

Drer\asb15b

1 of 14

Yes

Drer\asb16

1 of 14

Yes

Drer\asb18

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pla2g6

1 of 14

Drer\pnpla8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ripk2

1 of 14

Drer\ripk4

1 of 14

Yes

Drer\shank2b

1 of 14

Drer\si:ch211-223a10.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ush1gb

1 of 14

Drer\zdhhc13

1 of 14

Drer\zdhhc17

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (50)

Cele\unc-44

6 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Cele\C06G3.4

1 of 14

Yes

Cele\C18H2.4

1 of 14

Yes

Cele\C18H2.5

1 of 14

Yes

Cele\C27A7.5

1 of 14

Cele\C45B2.6

1 of 14

Cele\D1065.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F36D3.5

1 of 14

Yes

Cele\F37A4.4

1 of 14

Yes

Cele\F40G9.17

1 of 14

Yes

Cele\F56D5.9

1 of 14

Yes

Cele\F56H1.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\ipla-7

1 of 14

Cele\K09D9.11

1 of 14

Yes

Cele\kdin-1

1 of 14

Cele\kri-1

1 of 14

Cele\lido-18

1 of 14

Yes

Cele\mel-11

1 of 14

Cele\mlt-2

1 of 14

Yes

Cele\mlt-3

1 of 14

Yes

Cele\mlt-4

1 of 14

Yes

Cele\nfki-1

1 of 14

Yes

Cele\R05H5.4

1 of 14

Cele\R31.2

1 of 14

Yes

Cele\sel-15

1 of 14

Cele\T08G3.7

1 of 14

Yes

Cele\trpa-1

1 of 14

Cele\Y106G6H.14

1 of 14

Cele\ZC581.7

1 of 14

Anopheles gambiae (African malaria mosquito) (47)

Agam\AgaP_AGAP009937

10 of 12

Yes

Agam\AgaP_AGAP002272

5 of 12

Yes

Agam\AgaP_AGAP001947

2 of 12

Agam\AgaP_AGAP008471

2 of 12

Yes

Agam\AgaP_AGAP009428

2 of 12

Agam\AgaP_AGAP009521

2 of 12

Yes

Agam\AgaP_AGAP010571

2 of 12

Yes

Agam\AgaP_AGAP010934

2 of 12

Yes

Agam\AgaP_AGAP011724

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009956

1 of 12

Yes

Agam\AgaP_AGAP010269

1 of 12

Agam\AgaP_AGAP011697

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (89)

Atha\ANK1

3 of 13

Yes

Atha\AT1G03670

3 of 13

Yes

Atha\AT1G10340

3 of 13

Yes

Atha\AT1G34050

3 of 13

Yes

Atha\AT2G03430

3 of 13

Yes

Atha\AT2G24600

3 of 13

Yes

Atha\AT4G03490

3 of 13

Yes

Atha\AT4G03500

3 of 13

Yes

Atha\AT5G14230

3 of 13

Yes

Atha\AT5G54710

3 of 13

Yes

Atha\XBAT31

3 of 13

Yes

Atha\AT1G05640

2 of 13

Atha\AT1G07710

2 of 13

Yes

Atha\AT2G31820

2 of 13

Atha\AT3G09550

2 of 13

Yes

Atha\AT3G24530

2 of 13

Yes

Atha\AT4G03440

2 of 13

Yes

Atha\AT4G03460

2 of 13

Yes

Atha\AT4G03470

2 of 13

Yes

Atha\AT4G03480

2 of 13

Yes

Atha\AT4G05040

2 of 13

Yes

Atha\AT4G14390

2 of 13

Yes

Atha\AT5G50140

2 of 13

Yes

Atha\AT5G60070

2 of 13

Yes

Atha\ITN1

2 of 13

Yes

Atha\TPR10

2 of 13

Atha\XBAT32

2 of 13

Yes

Atha\XBAT33

2 of 13

Yes

Atha\ACD6

1 of 13

Atha\AKR2

1 of 13

Yes

Atha\AKR2B

1 of 13

Yes

Atha\ANK6

1 of 13

Yes

Atha\ANK

1 of 13

Yes

Atha\AT1G14480

1 of 13

Yes

Atha\AT1G14500

1 of 13

Yes

Atha\AT1G18160

1 of 13

Atha\AT1G34046

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G02810

1 of 13

Atha\AT3G03790

1 of 13

Atha\AT3G04140

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G14780

1 of 13

Atha\AT4G19150

1 of 13

Yes

Atha\AT4G26120

1 of 13

Yes

Atha\AT4G32250

1 of 13

Yes

Atha\AT5G15500

1 of 13

Yes

Atha\AT5G37450

1 of 13

Atha\AT5G40540

1 of 13

Atha\AT5G48940

1 of 13

Yes

Atha\AT5G50180

1 of 13

Atha\AT5G51160

1 of 13

Yes

Atha\AT5G54620

1 of 13

Yes

Atha\AT5G54700

1 of 13

Yes

Atha\AT5G54720

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\BOP2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\NPR1

1 of 13

Yes

Atha\NPR3

1 of 13

Yes

Atha\NPR4

1 of 13

Yes

Atha\PIA1

1 of 13

Yes

Atha\RLP46

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\NAS6

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Scer\HOS4

1 of 13

Scer\MBP1

1 of 13

Yes

Scer\YCR051W

1 of 13

Yes

Scer\YGL242C

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\akr1

1 of 12

Yes

Spom\bip1

1 of 12

Yes

Spom\gde1

1 of 12

Yes

Spom\res1

1 of 12

Yes

Spom\res2

1 of 12

Yes

Spom\SPAC6C3.08

1 of 12

Yes

Spom\SPAC105.02c

1 of 12

Yes

Spom\SPBP16F5.05c

1 of 12

Yes

Spom\SPCP1E11.10

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\ansA

1 of 11

Yes

Ecol\ansB

1 of 11

Yes

Ecol\yahD

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ank. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (44)

8 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

Alk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dpy

1 of 13

Fem-1

1 of 13

Git

1 of 13

Hip14

1 of 13

Ilk

1 of 13

iPLA2-VIA

1 of 13

Kank

1 of 13

Mbs

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pyx

1 of 13

Raf

1 of 13

Ror

1 of 13

sowah

1 of 13

TrpA1

1 of 13

wnd

1 of 13

wtrw

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ANK1; ankyrin 1

model of hereditary spherocytosis type 1

IEA

(FlyBase, 2019-)

ANK3; ankyrin 3

model of autosomal recessive intellectual developmental disorder 37

IEA

(FlyBase, 2019-)

ANK2; ankyrin 2

model of ankyrin-B-related cardiac arrhythmia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANK1; ankyrin 1

11 of 14

612641

SPHEROCYTOSIS, TYPE 1; SPH1

hereditary spherocytosis type 1

ANK3; ankyrin 3

10 of 14

600465

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 37; MRT37

autosomal recessive intellectual developmental disorder 37

ANK2; ankyrin 2

8 of 14

106410

CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED

ankyrin-B-related cardiac arrhythmia

ANKRD44; ankyrin repeat domain 44

3 of 14

620861

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Ank - DIP1

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Tay and Pek, 2019)

protein-protein

Physical Interaction

Assay

References

Ank - CG9467

experimental knowledge based

(Guruharsha et al., 2011)

Ank - Pi3K68D

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68608

DroID - A comprehensive database of gene and protein interactions.

FBgn0011747

MIST (protein-protein) - An integrated Molecular Interaction Database

43770

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

COPI-mediated anterograde transport

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KIE7

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102A3-102A3

Sequence location

4:115,074..129,849 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102A3-102A3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

101F-102A

(determined by in situ hybridisation)

(Dubreuil and Yu, 1994)

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

62020

w¹¹¹⁸; Mi{ET1}Ank^MB09683

43965

y¹ v¹; P{TRiP.GL01575}attP2

605976

y¹ w^*; TI{TI}FRT101F Ank^J

602194

y¹ w¹¹¹⁸; TI{TI}FRT101F Ank^A

31115

y¹ v¹; P{TRiP.JF01588}attP2/TM3, Sb¹

91341

y¹ w^*; TI{CRIMIC.TG4.0}Ank^{CR01879-TG4.0}

97738

y¹ w¹¹¹⁸; TI{DH.0}Ank^{CR01879-DH.PT-GFSTF.0}

Kyoto

119160

y¹ w¹¹¹⁸; TI{TI}FRT101F Ank^A

118958

y¹ w¹¹¹⁸; TI{DH.0}Ank^{CR01879-DH.PT-GFSTF.0}

VDRC

v25945

w¹¹¹⁸; P{GD10431}v25945

v25946

w¹¹¹⁸; P{GD10431}v25946

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (105)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD10053

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011747

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011747

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Dubreuil and Yu, 1994)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Ank is not required for the recruitment of Spectrin to postsynaptic muscle membranes at the neuromuscular junction.

(Pielage et al., 2006)

Ank contributes to the Spectrin-dependent control of synapse development.

(Pielage et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The molecular evolution of the Rel/NF-κB and IκB proteins is studied in parallel. Phylogenetic analysis allows the structure of the putative ancestor genes to be defined and proposes and evolutionary model that clusters both families in a unique Rel/NF-κB/IκB superfamily.

(Huguet et al., 1997)

Elimination of α-Spec from follicle cells does not appear to prevent the assembly of conventional β-Spec and Ank products at the lateral domain of the follicle cell plasma membrane.

(Lee et al., 1997)

Interaction between Ank and Nrg molecules occurs by a mechanism that couples the positional information of cell adhesion to the polar assembly of Ank.

(Dubreuil et al., 1996)

The Ank gene product is a component of spectrosomes but not fusomes.

(de Cuevas et al., 1996)

Ank was identified by amplification of genomic DNA with oligonucleotide primers based on a conserved region of mammalian brain ankyrin.

(Dubreuil and Yu, 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ank CG1651

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

ANK

(Khan et al., 2023, Wang et al., 2022, Tay and Pek, 2019, Khush and Lemaitre, 2000, Pebusque et al., 1998)

Ankyrin

(Aromolaran et al., 2021)

CG1651

(Schwartz et al., 2016, Christis and Munro, 2012, Cammarato et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Ni et al., 2008, Ryder et al., 2004, Jensen, 2001.4.18, Goldstein and Gunawardena, 2000)

CG32008

DAnk1

(Mazock et al., 2010)

Dank1

(Deng et al., 2020, Bouley et al., 2000)

ank

(Figueiredo et al., 2014, Pielage et al., 2006, Jasper et al., 2002)

dank1

(Garbe et al., 2007)

Name Synonyms

Ank1

(Jegla et al., 2016)

Ankyrin

(Meyer et al., 2024, Finegan and Bergstralh, 2020, Figueiredo et al., 2014, Cammarato et al., 2011, Silies and Klämbt, 2011, Khanna et al., 2010, Pielage et al., 2006)

ankyrin

(Figueiredo et al., 2014, Kinoshita et al., 2014, Mazock et al., 2010, Mudiganti et al., 2010, Bakal et al., 2007, Kohsaka et al., 2007, Das et al., 2006, Yamashita et al., 2005, Deng and Lin, 2001, Dubreuil et al., 1997, Dubreuil, 1994.10.25)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43770

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0KIE7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0KIE7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43770/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011747

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011747

FlyMine - An integrated database for Drosophila genomics

FBgn0011747

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1651

MARRVEL_MODEL - MARRVEL (model organism gene)

43770

Linkouts

BioGRID - A database of protein and genetic interactions.

68608

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011747

DroID - A comprehensive database of gene and protein interactions.

FBgn0011747

DRSC - Results frm RNAi screens

FBgn0011747

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ank_1
Ank_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011747

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011747

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1651

Flygut - An atlas of the Drosophila adult midgut

FBgn0011747

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011747

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Toll and Imd signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

43770

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

COPI-mediated anterograde transport

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KIE7

References (135)

The following external sites may use different assemblies or annotations than FlyBase.

-1.88

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