FlyBase Gene Report: Dmel\sowah

General Information

Symbol

Dmel\sowah

Species

D. melanogaster

Name

sosondowah

Annotation Symbol

CG10632

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036302

Gene Model Status

Current

Stock Availability

21 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

69C6-69C8

Sequence location

3L:12,537,513..12,572,542 [-]

Recombination map

3-38

RefSeq locus

NT_037436 REGION:12537513..12572542

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sowah for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry B7Z0B0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

The gene contains micro-exons of 12, 3, 3, and 6 bases based on cDNA evidence that do not consistently appear in the alignments.

Multiphase exon postulated: exon reading frame differs in alternative transcripts.

GB:AY051801, GB:CO152972, and GB:AI404375, are aligned incorrectly to genome. Several microexons do not appear in the alignments.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sowah-RG

FBtr0300888

NM_001144471

2749

780

sowah-RH

FBtr0300887

NM_001144469

2360

527

sowah-RI

FBtr0300889

NM_168503

2314

635

sowah-RJ

FBtr0332042

NM_001144470

1964

548

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

sowah-PG

FBpp0290110

85.3

780

10.08

FBpp0290109

58.7

527

7.96

FBpp0290111

69.8

635

9.79

FBpp0304352

60.5

548

9.70

B7Z0B1

NP_001137942

ACL83297

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sowah using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sowah_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sowah in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sowah

View exonic expression by tissue for Dmel\sowah

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036302

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39438/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036302

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036302

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036302

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10632

Flygut - An atlas of the Drosophila adult midgut

FBgn0036302

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sowah

Transgenic constructs containing regulatory region of sowah

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene partially disrupted in

Df(3L)sowah^EGP1

(Maeso et al., 2012)

Df(3L)sowah^EGP3

(Maeso et al., 2012)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

sowah^f01127

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sowah^GD6711

viable, with Scer\GAL4^Mef2.PR

sowah^GD6711

viable, with Scer\GAL4^pnr-MD237

sowah^GD6711

viable, with Scer\GAL4^tin.CΔ4

sowah^GD6711

Sterility

Allele

fertile

sowah^f01127

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\SOWAHB

6 of 14

Yes

Hsap\SOWAHA

5 of 14

Yes

Hsap\SOWAHC

5 of 14

Yes

Hsap\SOWAHD

4 of 14

Yes

Hsap\ANKEF1

1 of 14

Hsap\ANKK1

1 of 14

Hsap\ANKRD10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ASB7

1 of 14

Hsap\CDKN2C

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PPP1R12A

1 of 14

Hsap\PPP1R27

1 of 14

Hsap\PSMD10

1 of 14

Yes

Hsap\TANC1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Sowahb

6 of 14

Yes

Rnor\Sowahc

6 of 14

Yes

Rnor\Sowaha

5 of 14

Yes

Rnor\Sowahd

4 of 14

Yes

Rnor\Ankdd1a

1 of 14

Rnor\Ankrd10

1 of 14

Yes

Rnor\Ankrd28

1 of 14

Rnor\Ankrd52

1 of 14

Rnor\Ankrd53

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tanc1

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Sowaha

5 of 14

Yes

Mmus\Sowahb

5 of 14

Yes

Mmus\Sowahc

5 of 14

Yes

Mmus\Sowahd

4 of 14

Yes

Mmus\Ankrd10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\sowaha

6 of 13

Yes

Xtro\sowahc

5 of 13

Yes

Xtro\ube2g1

5 of 13

Xtro\sowahb

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ppp1r12a

1 of 13

Xtro\psmd10

1 of 13

Yes

Danio rerio (Zebrafish) (20)

Drer\sowahca

6 of 14

Yes

Drer\sowahcb

6 of 14

Yes

Drer\sowahab

4 of 14

Yes

Drer\sowahd

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100535451

1 of 14

Drer\LOC110438397

1 of 14

Yes

Drer\ppp1r12c

1 of 14

Drer\ripk4

1 of 14

Yes

Drer\tanc1a

1 of 14

Drer\tanc1b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\C46H3.2

1 of 14

Yes

Cele\kri-1

1 of 14

Yes

Cele\nphp-2

1 of 14

Yes

Cele\swah-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP005008

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (10)

Atha\ANK1

1 of 13

Yes

Atha\ANK

1 of 13

Yes

Atha\AT1G05640

1 of 13

Yes

Atha\AT1G07710

1 of 13

Yes

Atha\AT2G31820

1 of 13

Yes

Atha\AT4G03500

1 of 13

Yes

Atha\AT4G10720

1 of 13

Yes

Atha\AT5G60070

1 of 13

Yes

Atha\ITN1

1 of 13

Yes

Atha\XBAT31

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\AKR2

1 of 13

Yes

Scer\AVO2

1 of 13

Yes

Scer\NAS6

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC6C3.08

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sowah. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Ank

1 of 13

Mbs

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOWAHB; sosondowah ankyrin repeat domain family member B

6 of 14

SOWAHA; sosondowah ankyrin repeat domain family member A

5 of 14

SOWAHC; sosondowah ankyrin repeat domain family member C

5 of 14

SOWAHD; sosondowah ankyrin repeat domain family member D

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sowah - flfl

pull down, Identification by mass spectrometry, autoradiography

(Karman et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64787

DroID - A comprehensive database of gene and protein interactions.

FBgn0036302

MIST (protein-protein) - An integrated Molecular Interaction Database

39438

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-38

Cytogenetic map

69C6-69C8

Sequence location

3L:12,537,513..12,572,542 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69C6-69C8

Limits computationally determined from genome sequence between P{PZ}l(3)05088⁰⁵⁰⁸⁸ and P{PZ}l(3)06924⁰⁶⁹²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-38

(FlyBase, 2016)

3-32.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

71516

w¹¹¹⁸; P{VT029739-p65.AD}attP40

601386

w¹¹¹⁸; P{VT029740-p65.AD}attP40

72691

w¹¹¹⁸; P{VT029739-GAL4.DBD}attP2

75529

w¹¹¹⁸; P{VT029740-GAL4.DBD}attP2

18412

w¹¹¹⁸; PBac{WH}sowah^f01127

606834

w^*; sowah^EGP2/TM6B, Tb¹

35109

y¹ w^*; Mi{MIC}sowah^MI02324

22927

y¹ w^67c23; Mi{ET1}sowah^MB00901

23001

y¹ w^67c23; Mi{ET1}sowah^MB01147

Korea

13756

P{VT029739-GAL4}attP2

13757

P{VT029740-GAL4}attP2

VDRC

v39714

w¹¹¹⁸; P{GD6711}v39714

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (56)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036302

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036302

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG10632 BcDNA:GM09162

(BDGP Project Members, 2000-)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: sowah CG10632

(Irimia et al., 2008)

Nomenclature comments

Etymology

Linkage between CG10632 and Iroquois genes has been maintained in members of all major metazoan groups, encompassing more than 600 million years of evolution. For this reason, CG10632 has been named 'sosondowah' after the mythological hunter tied to her doorpost by the Iroquois sky's goddess.

(Irimia et al., 2008)

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BcDNA:GM09162

CG10632

(Hosono et al., 2015, Kerner et al., 2009, Perkins et al., 2009, Irimia et al., 2008, Kim et al., 2005)

Sowah

(Karman et al., 2020)

sowah

(Lee et al., 2023, Pang et al., 2021, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Kwon et al., 2013, Maeso et al., 2012, Friedman et al., 2011, Irimia et al., 2008)

Name Synonyms

Sosondowah

(Irimia et al., 2008)

sosondowah

Secondary FlyBase IDs

FBgn0064944

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39438

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

B7Z0B0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

B7Z0B0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036302

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39438/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036302

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036302

FlyMine - An integrated database for Drosophila genomics

FBgn0036302

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10632

MARRVEL_MODEL - MARRVEL (model organism gene)

39438

Linkouts

BioGRID - A database of protein and genetic interactions.

64787

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036302

DroID - A comprehensive database of gene and protein interactions.

FBgn0036302

DRSC - Results frm RNAi screens

FBgn0036302

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sowah_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036302

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036302

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10632

Flygut - An atlas of the Drosophila adult midgut

FBgn0036302

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032448

MIST (protein-protein) - An integrated Molecular Interaction Database

39438

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (46)

The following external sites may use different assemblies or annotations than FlyBase.

-0.96

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