FlyBase Gene Report: Dmel\mtt

General Information

Symbol

Dmel\mtt

Species

D. melanogaster

Name

mangetout

Annotation Symbol

CG30361

Feature Type

protein_coding_gene

FlyBase ID

FBgn0050361

Gene Model Status

Current

Stock Availability

165 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

mXr, DmXR

Key Links

Genomic Location

Cytogenetic map

44D1-44D2

Sequence location

2R:8,473,956..8,532,294 [-]

Recombination map

2-59

RefSeq locus

NT_033778 REGION:8473956..8532294

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from direct assay

(Mitri et al., 2004)

NOT enables glutamate binding

inferred from direct assay

(Mitri et al., 2004)

NOT enables glutamate receptor activity

inferred from direct assay

(Mitri et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000337, InterPro:IPR011500, InterPro:IPR017978, InterPro:IPR017979

(InterPro Project Members, 2004-)

NOT enables glutamate binding

inferred from sequence or structural similarity

(Mitri et al., 2004)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adult feeding behavior

inferred from mutant phenotype

(Mitri et al., 2009)

involved_in phospholipase C-activating G protein-coupled receptor signaling pathway

inferred from direct assay

(Mitri et al., 2004)

involved_in response to insecticide

inferred from direct assay

(Mitri et al., 2009)

inferred from mutant phenotype

(Mitri et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000162, InterPro:IPR000337, InterPro:IPR011500, InterPro:IPR017978, InterPro:IPR017979

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in dendrite

inferred from direct assay

(Mitri et al., 2009)

located_in plasma membrane

inferred from direct assay

(Mitri et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with FLYBASE:mGluR; FB:FBgn0019985

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000162, InterPro:IPR000337, InterPro:IPR017978, InterPro:IPR017979

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001173583

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MXR METABOTROPIC GLUTAMATE-LIKE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MXR METABOTROPIC GLUTAMATE-LIKE RECEPTORS -: The insect mXR metabotropic glutamate-like receptors (mXR) diverge from classical metabotropic glutamate receptors as they lack the residues that interact with the the gamma-carboxylic group of glutamate. The ligand for mtt has not been identified, but experiments with head extracts indicate an endogenous ligand with a primary amino group and it may be involved in the avoidance response to L-canavanine. (Adapted from FBrf0174795 and FBrf0221506.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mtt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KF15)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mtt-RC

FBtr0088756

NM_206058

3894

780

mtt-RD

FBtr0273325

NM_001144147

7328

1415

mtt-RE

FBtr0273326

NM_136542

6368

1095

mtt-RF

FBtr0273327

NM_165609

5422

1248

mtt-RG

FBtr0330608

NM_001273877

7328

1472

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mtt-PC

FBpp0087835

86.0

780

7.95

FBpp0271833

156.5

1415

7.56

FBpp0271834

120.1

1095

7.64

FBpp0271835

139.1

1248

7.75

FBpp0303458

162.5

1472

7.69

A0A0B4KF15

NP_001260806

AGB93339

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mtt using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

labellum

(Mitri et al., 2009)

gustatory receptor neuron of the labellum

(Mitri et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

labellum

(Mitri et al., 2009)

tibia

(Mitri et al., 2009)

tarsal segment

(Mitri et al., 2009)

Additional Descriptive Data

mtt is detected in the labellum and in tibia/tarsae by RT-PCR. In situ hybridizaiton to the labellum shows that it is expressed in one gustatory receptor neuron per labellar chemosensillum.

(Mitri et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in dendrite

inferred from direct assay

(Mitri et al., 2009)

located_in plasma membrane

inferred from direct assay

(Mitri et al., 2004)

Expression Deduced from Reporters

Reporter: P{GawB}NP4288

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

gustatory receptor neuron of the labellum

(Mitri et al., 2009)

high salt/bitter-sensing neuron

(Mitri et al., 2009)

prothoracic leg taste bristle chemosensory neuron

(Mitri et al., 2009)

mesothoracic leg taste bristle chemosensory neuron

(Mitri et al., 2009)

metathoracic leg taste bristle chemosensory neuron

(Mitri et al., 2009)

labral sense organ neuron

(Mitri et al., 2009)

ventral cibarial sense organ neuron

(Mitri et al., 2009)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mtt in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mtt

View exonic expression by tissue for Dmel\mtt

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35832/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050361

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050361

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050361

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30361

Flygut - An atlas of the Drosophila adult midgut

FBgn0050361

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mtt

Transgenic constructs containing regulatory region of mtt

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7096

(Mitri et al., 2009, Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

mtt^HMS02793

partially lethal - majority die, with Scer\GAL4^4XHand

mtt^HMS02793

viable

viable, with Scer\GAL4^Act5C.PU

mtt^HMS00367

viable, with Scer\GAL4^HCH.Hand

mtt^HMS02793

viable (with Df(2R)Exel7096)

mtt^f06268

Other Phenotypes

Allele

abnormal feeding behavior, with Scer\GAL4^Gr66a.PD, mtt^f06268

mtt^RNAi.UAS

abnormal feeding behavior, with Scer\GAL4^Gr66a.PD, mtt^RNAi.UAS

mtt^f06268

abnormal feeding behavior, with Scer\GAL4^NP4288, mtt^f06268

mtt^RNAi.UAS

abnormal feeding behavior, with Scer\GAL4^NP4288, mtt^RNAi.UAS

mtt^f06268

abnormal feeding behavior | adult stage (with Df(2R)Exel7096)

mtt^f06268

abnormal feeding behavior | adult stage | recessive

mtt^f06268

abnormal visual behavior | adult stage, with Scer\GAL4^GMR.PU

mtt^HMS02793

decreased size | adult stage, with Scer\GAL4^GMR.PU

mtt^HMS02793

visible | adult stage, with Scer\GAL4^GMR.PU

mtt^HMS02793

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PU

mtt^HMS02793

eye disc, with Scer\GAL4^GMR.PU

mtt^HMS02793

interommatidial bristle, with Scer\GAL4^GMR.PU

mtt^HMS02793

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (41)

Hsap\GRM8

7 of 14

Yes

Hsap\GRM4

6 of 14

Yes

Hsap\GRM6

6 of 14

Yes

Hsap\GRM7

6 of 14

Yes

5 of 14

4 of 14

3 of 14

3 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPRC5B

1 of 14

Yes

Hsap\GPRC5C

1 of 14

Yes

Hsap\GPRC5D

1 of 14

Yes

Hsap\GPRC6A

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TAS1R2

1 of 14

Yes

Hsap\TAS1R3

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Grm6

7 of 14

Yes

Rnor\Grm8

7 of 14

Yes

Rnor\Grm7

6 of 14

Yes

Rnor\Grm2

5 of 14

Rnor\Grm3

5 of 14

Rnor\Grm4

5 of 14

Yes

Rnor\Grm1

3 of 14

Rnor\Grm5

3 of 14

Rnor\Casr

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gprc5b

1 of 14

Yes

Rnor\Gprc5c

1 of 14

Yes

Rnor\Gprc5d

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Vom2r9

1 of 14

Yes

Rnor\Vom2r16

1 of 14

Yes

Rnor\Vom2r27

1 of 14

Yes

Rnor\Vom2r28

1 of 14

Yes

Rnor\Vom2r37

1 of 14

Yes

Rnor\Vom2r44

1 of 14

Yes

Rnor\Vom2r46

1 of 14

Yes

Rnor\Vom2r47

1 of 14

Yes

Rnor\Vom2r53

1 of 14

Yes

Rnor\Vom2r62

1 of 14

Yes

Rnor\Vom2r64

1 of 14

Yes

Mus musculus (laboratory mouse) (53)

Mmus\Grm6

7 of 14

Yes

Mmus\Grm8

7 of 14

Yes

Mmus\Grm4

6 of 14

Yes

Mmus\Grm7

6 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gprc5b

1 of 14

Yes

Mmus\Gprc5c

1 of 14

Yes

Mmus\Gprc5d

1 of 14

Yes

Mmus\Gprc6a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vmn2r2

1 of 14

Yes

Mmus\Vmn2r5

1 of 14

Yes

Mmus\Vmn2r18

1 of 14

Yes

Mmus\Vmn2r24

1 of 14

Yes

Mmus\Vmn2r29

1 of 14

Yes

Mmus\Vmn2r32

1 of 14

Yes

Mmus\Vmn2r33

1 of 14

Yes

Mmus\Vmn2r35

1 of 14

Yes

Mmus\Vmn2r38

1 of 14

Yes

Mmus\Vmn2r42

1 of 14

Yes

Mmus\Vmn2r43

1 of 14

Yes

Mmus\Vmn2r45

1 of 14

Yes

Mmus\Vmn2r57

1 of 14

Yes

Mmus\Vmn2r62

1 of 14

Yes

Mmus\Vmn2r63

1 of 14

Yes

Mmus\Vmn2r76

1 of 14

Yes

Mmus\Vmn2r81

1 of 14

Yes

Mmus\Vmn2r91

1 of 14

Yes

Mmus\Vmn2r92

1 of 14

Yes

Mmus\Vmn2r94

1 of 14

Yes

Mmus\Vmn2r95

1 of 14

Yes

Mmus\Vmn2r96

1 of 14

Yes

Mmus\Vmn2r97

1 of 14

Yes

Mmus\Vmn2r98

1 of 14

Yes

Mmus\Vmn2r99

1 of 14

Yes

Mmus\Vmn2r100

1 of 14

Yes

Mmus\Vmn2r107

1 of 14

Yes

Mmus\Vmn2r121

1 of 14

Yes

Mmus\Vmn2r124

1 of 14

Yes

Mmus\Vmn2r-ps158

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (49)

Xtro\grm8

4 of 13

Yes

Xtro\grm7

3 of 13

Yes

Xtro\grm2

2 of 13

Xtro\grm4

2 of 13

Yes

Xtro\grm8l

2 of 13

Yes

Xtro\ak3

1 of 13

Xtro\c11orf49

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100490381

1 of 13

Yes

Xtro\LOC100490505

1 of 13

Yes

Xtro\LOC100491800

1 of 13

Yes

Xtro\LOC100493136

1 of 13

Yes

Xtro\LOC100494461

1 of 13

Yes

Xtro\LOC100496766

1 of 13

Yes

Xtro\LOC100496848

1 of 13

Yes

Xtro\LOC100497076

1 of 13

Yes

Xtro\LOC100497643

1 of 13

Yes

Xtro\LOC101733546

1 of 13

Yes

Xtro\LOC101734131

1 of 13

Yes

Xtro\LOC105946413

1 of 13

Xtro\LOC108646252

1 of 13

Yes

Xtro\LOC108648105

1 of 13

Yes

Xtro\LOC116409579

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB991396

1 of 13

Yes

Danio rerio (Zebrafish) (71)

Drer\grm8b

6 of 14

Yes

Drer\grm4

5 of 14

Yes

Drer\grm6a

5 of 14

Yes

Drer\grm6b

5 of 14

Yes

Drer\grm8a

5 of 14

Yes

Drer\grm2b

4 of 14

Drer\grm3

4 of 14

Drer\LOC100331190

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\gprc5bb

1 of 14

Yes

Drer\gprc5c

1 of 14

Yes

Drer\gprc6a

1 of 14

Yes

Drer\gucy2g

1 of 14

Drer\LOC793043

1 of 14

Yes

Drer\LOC100007225

1 of 14

Yes

Drer\LOC110439046

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\olfcd2

1 of 14

Yes

Drer\olfcd3

1 of 14

Yes

Drer\olfce2

1 of 14

Yes

Drer\olfcg1

1 of 14

Yes

Drer\olfcg2

1 of 14

Yes

Drer\olfcg4

1 of 14

Yes

Drer\olfcg5

1 of 14

Yes

Drer\olfcg12

1 of 14

Yes

Drer\olfch1

1 of 14

Yes

Drer\olfcj1

1 of 14

Yes

Drer\olfck1

1 of 14

Yes

Drer\olfck2

1 of 14

Yes

Drer\olfcn1

1 of 14

Yes

Drer\olfcq1

1 of 14

Yes

Drer\olfcq2

1 of 14

Yes

Drer\olfcq3

1 of 14

Yes

Drer\olfcq4

1 of 14

Yes

Drer\olfcq5

1 of 14

Yes

Drer\olfcq6

1 of 14

Yes

Drer\olfcq8

1 of 14

Yes

Drer\olfcq10

1 of 14

Yes

Drer\olfcq12

1 of 14

Yes

Drer\olfcq13

1 of 14

Yes

Drer\olfcq14

1 of 14

Yes

Drer\olfcq15

1 of 14

Yes

Drer\olfcq16

1 of 14

Yes

Drer\olfcq17

1 of 14

Yes

Drer\olfcq18

1 of 14

Yes

Drer\olfcq19

1 of 14

Yes

Drer\olfcr1

1 of 14

Yes

Drer\olfcs1

1 of 14

Yes

Drer\olfcs2

1 of 14

Yes

Drer\olfcu1

1 of 14

Yes

Drer\olfcv1

1 of 14

Yes

Drer\olfcv2

1 of 14

Yes

Drer\olfcv3

1 of 14

Yes

Drer\olfcw1

1 of 14

Yes

Drer\olfcx1

1 of 14

Yes

Drer\olfcx3

1 of 14

Yes

Drer\si:dkey-37g12.1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\mgl-1

4 of 14

Yes

Cele\mgl-2

4 of 14

Yes

Cele\mgl-3

3 of 14

Yes

Cele\C30A5.10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\GPRMGL5

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (10)

Atha\GLR3.3

2 of 13

Yes

Atha\GLR3.6

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mtt. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (24)

6 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

night blindness, congenital stationary, 1B, autosomal recessive

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

mtt^HMS02793

model of congenital stationary night blindness 1B

CEA

(Chen et al., 2024)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GRM6; glutamate metabotropic receptor 6

model of congenital stationary night blindness 1B

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRM8; glutamate metabotropic receptor 8

7 of 14

601116

GRM4; glutamate metabotropic receptor 4

6 of 14

604100

GRM6; glutamate metabotropic receptor 6

6 of 14

604096

NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B; CSNB1B

congenital stationary night blindness 1B

GRM7; glutamate metabotropic receptor 7

6 of 14

604101

NEURODEVELOPMENTAL DISORDER WITH SEIZURES, HYPOTONIA, AND BRAIN IMAGING ABNORMALITIES; NEDSHBA

GRM3; glutamate metabotropic receptor 3

5 of 14

601115

GRM2; glutamate metabotropic receptor 2

4 of 14

604099

GRM1; glutamate metabotropic receptor 1

3 of 14

GLUTAMATE RECEPTOR, METABOTROPIC, 1; GRM1

GRM5; glutamate metabotropic receptor 5

3 of 14

604102

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0050361

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-59

Cytogenetic map

44D1-44D2

Sequence location

2R:8,473,956..8,532,294 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44D1-44D2

Limits computationally determined from genome sequence between P{lacW}Rs1^k09514&P{lacW}l(2)k03110^k03110 and P{lacW}Vps25^k08904&P{lacW}ptc^k02507

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44D-44E

(Mitri, 2003.8.28, Grau et al., 1997)

Experimentally Determined Recombination Data

Location

2-59

(FlyBase, 2016)

2-57.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (165)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12604

P{VT013594-GAL4}attP2

12873

P{VT013600-GAL4}attP2

12874

P{VT013608-GAL4}attP2

12875

P{VT013612-GAL4}attP2

13217

P{VT013592-GAL4}attP2

13626

P{VT013596-GAL4}attP2

14773

P{VT013605-GAL4}attP2

14849

P{VT013611-GAL4}attP2

14919

P{VT013610-GAL4}attP2

VDRC

v330081

P{VSH330081}attP40

v102982

P{KK112979}VIE-260B

v203911

P{VT013602-GAL4}attP2

More stocks available...

Genomic Clones (38)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0050361

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0050361

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: mXr Glu-RB

(Mitri et al., 2004)

Source for merge of: mXr anon-WO0170980.4 anon-WO0170980.5

(FlyBase, 1996-)

Source for merge of: CG18447 CG8692

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG18447 and CG8692 merged as CG30361 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of mXr anon-WO0170980.4 anon-WO0170980.5 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG18447

CG30361

(Mao et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Kondo et al., 2020, Meadows, 2017.1.11, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Metpally and Sowdhamini, 2005, Yu et al., 2004, Vanden Broeck, 2001)

CG8692

(Brody and Cravchik, 2000)

DmGluBR

(Mitri et al., 2004)

DmGluRB

(Grau et al., 1997)

DmXR

(Guo et al., 2020, Mitri et al., 2009, Mitri et al., 2004)

Glu-RB

GluRB

(Qualmann et al., 2000)

Mtt

(Zhu et al., 2017)

anon-WO0170980.4

anon-WO0170980.5

mXr

(Jungreis et al., 2011, Hazelett et al., 2009)

mtt

(Chen et al., 2024, Schlichting et al., 2022, Montell, 2021, Scaplen and Petruccelli, 2021, Kondo et al., 2020, Yanagawa et al., 2020, Fowler et al., 2019, Goel et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2016-, Morozova et al., 2015, Lee et al., 2012, Rodriguez et al., 2012, Cook et al., 2010.2.12, Mitri et al., 2009)

Name Synonyms

DmX receptor

(Mitri et al., 2009)

mXr

mangetout

(Mitri et al., 2009)

Secondary FlyBase IDs

FBgn0020430
FBgn0033298
FBgn0033299
FBgn0046529
FBgn0046537

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35832

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KF15

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KF15

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35832/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050361

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050361

FlyMine - An integrated database for Drosophila genomics

FBgn0050361

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30361

MARRVEL_MODEL - MARRVEL (model organism gene)

35832

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0050361

DroID - A comprehensive database of gene and protein interactions.

FBgn0050361

DRSC - Results frm RNAi screens

FBgn0050361

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050361

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0050361

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30361

Flygut - An atlas of the Drosophila adult midgut

FBgn0050361

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034263

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

-0.69

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