FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\GluRIA
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General Information
Symbol
Dmel\GluRIA
Species
D. melanogaster
Name
Glutamate receptor IA
Annotation Symbol
CG8442
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004619
Gene Model Status
Current
Stock Availability
95 publicly available
Gene Summary
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate. (UniProt, Q03445)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Glu-RI, DGluR-I, Glutamate receptor I, GluR1, Glu-R1

Key Links
Genomic Location
Cytogenetic map
65C1-65C1
Sequence location
Recombination map
3-17
RefSeq locus
NT_037436 REGION:6624032..6635059
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables kainate selective glutamate receptor activity
inferred from direct assay
(Ultsch et al., 1992)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables glutamate receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(GO Reference Genome Project, 2011-)
enables ligand-gated monoatomic ion channel activity
inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594
(InterPro Project Members, 2004-)
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in monoatomic cation transport
inferred from direct assay
(Ultsch et al., 1992)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in modulation of chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(GO Reference Genome Project, 2011-)
involved_in synaptic transmission, glutamatergic
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of ionotropic glutamate receptor complex
inferred by curator from GO:0015277
(Ultsch et al., 1992)
located_in membrane
inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(GO Reference Genome Project, 2011-)
is_active_in postsynaptic density membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q03445)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
UNCLASSIFIED NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS -
This group comprises ionotropic glutamate receptors which are not selectively activated by NMDA and do not fall into the GluRII sub-type expressed at the neuromuscular junction. (Adapted from FBrf0209026.)
Protein Function (UniProtKB)
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate.
(UniProt, Q03445)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\GluRIA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q03445)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
GluRIA-RA
FBtr0076982
NM_057507
3810
991
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
GluRIA-PA
FBpp0076691
111.7
991
7.24
Q03445
NP_476855
AAF50652
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homooligomer.

(UniProt, Q03445)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluRIA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\GluRIA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GluRIA
Transgenic constructs containing regulatory region of GluRIA
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\GRIA3
13 of 14
Yes
Yes
4  
Hsap\GRIA1
12 of 14
No
Yes
2  
Hsap\GRIA2
12 of 14
No
Yes
2  
Hsap\GRIA4
12 of 14
No
Yes
Hsap\GRIK4
7 of 14
No
No
Hsap\GRIK1
6 of 14
No
No
1  
Hsap\GRIK3
6 of 14
No
No
Hsap\GRIK2
5 of 14
No
No
Hsap\GRIK5
5 of 14
No
No
1  
Hsap\GRID1
4 of 14
No
No
Hsap\GRID2
3 of 14
No
No
Hsap\GRIN2B
3 of 14
No
No
Hsap\GRIN2C
3 of 14
No
No
Hsap\GRIN3A
3 of 14
No
Yes
Hsap\GRIN3B
3 of 14
No
Yes
Hsap\GRIN1
2 of 14
No
No
Hsap\GRIN2A
2 of 14
No
No
Hsap\GRIN2D
2 of 14
No
No
Hsap\GABBR1
1 of 14
No
No
Hsap\GABBR2
1 of 14
No
No
Hsap\GRM5
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Gria3
13 of 14
Yes
Yes
Rnor\Gria4
12 of 14
No
Yes
Rnor\Gria1
11 of 14
No
Yes
Rnor\Gria2
11 of 14
No
Yes
Rnor\Grik4
7 of 14
No
No
Rnor\Grik2
6 of 14
No
No
Rnor\Grik3
6 of 14
No
No
Rnor\Grik5
6 of 14
No
No
Rnor\Grik1
5 of 14
No
No
Rnor\Grid2
3 of 14
No
No
Rnor\Grin2b
3 of 14
No
No
Rnor\Grin2c
3 of 14
No
No
Rnor\Grin3a
3 of 14
No
Yes
Rnor\Grid1
2 of 14
No
No
Rnor\Grin1
2 of 14
No
No
Rnor\Grin2a
2 of 14
No
No
Rnor\Grin2d
2 of 14
No
No
Rnor\Grin3b
2 of 14
No
Yes
Mus musculus (laboratory mouse) (18)
Mmus\Gria1
12 of 14
Yes
Yes
3  
Mmus\Gria3
12 of 14
Yes
Yes
Mmus\Gria4
12 of 14
Yes
Yes
Mmus\Gria2
11 of 14
No
Yes
Mmus\Grik4
7 of 14
No
No
Mmus\Grik1
6 of 14
No
No
Mmus\Grik3
6 of 14
No
No
Mmus\Grik5
6 of 14
No
No
Mmus\Grik2
5 of 14
No
No
Mmus\Grid1
4 of 14
No
No
Mmus\Grid2
3 of 14
No
No
Mmus\Grin2c
3 of 14
No
No
Mmus\Grin3a
3 of 14
No
Yes
Mmus\Grin3b
3 of 14
No
Yes
Mmus\Grin1
2 of 14
No
No
Mmus\Grin2b
2 of 14
No
No
Mmus\Grin2d
2 of 14
No
No
Mmus\Grin2a
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\gria3
7 of 13
Yes
Yes
Xtro\gria4
6 of 13
No
Yes
Xtro\gria1
5 of 13
No
Yes
Xtro\gria2
5 of 13
No
Yes
Xtro\grik4
4 of 13
No
No
Xtro\serpinb1
4 of 13
No
No
Xtro\grik3
3 of 13
No
No
Xtro\grik5
3 of 13
No
No
Xtro\dedd2
2 of 13
No
No
Xtro\grid2
2 of 13
No
No
Xtro\grik5-like.1
2 of 13
No
No
Xtro\abca5
1 of 13
No
No
Xtro\abcg1
1 of 13
No
No
Xtro\ak3
1 of 13
No
No
Xtro\dhrs7
1 of 13
No
No
Xtro\gabbr1
1 of 13
No
No
Xtro\gabbr2
1 of 13
No
No
Xtro\gmpr
1 of 13
No
Yes
Xtro\grid1
1 of 13
No
No
Xtro\grik1
1 of 13
No
No
Xtro\grik2
1 of 13
No
No
Xtro\grin1
1 of 13
No
No
Xtro\grin2a
1 of 13
No
No
Xtro\grin2b
1 of 13
No
No
Xtro\grin3b
1 of 13
No
Yes
Xtro\grm5
1 of 13
No
No
Xtro\lrfn5
1 of 13
No
No
Xtro\lrrn4cl
1 of 13
No
Yes
Xtro\mettl4
1 of 13
No
No
Xtro\vtcn1
1 of 13
No
Yes
Danio rerio (Zebrafish) (33)
Drer\gria3a
13 of 14
Yes
Yes
Drer\gria3b
13 of 14
Yes
Yes
Drer\gria1a
12 of 14
No
Yes
Drer\gria1b
12 of 14
No
Yes
Drer\gria2a
12 of 14
No
Yes
Drer\gria2b
12 of 14
No
Yes
Drer\gria4b
12 of 14
No
Yes
Drer\gria4a
11 of 14
No
Yes
Drer\grik4
7 of 14
No
No
Drer\grik1a
6 of 14
No
No
Drer\LOC100334689
6 of 14
No
No
Drer\grik1b
5 of 14
No
No
Drer\grik2
5 of 14
No
No
Drer\grik5
5 of 14
No
No
Drer\grid1a
4 of 14
No
No
Drer\grid1b
4 of 14
No
No
Drer\grid2
3 of 14
No
No
Drer\grin2bb
3 of 14
No
No
Drer\grin2ca
3 of 14
No
No
Drer\grin2cb
3 of 14
No
No
Drer\grin3a
3 of 14
No
Yes
Drer\grin3ba
3 of 14
No
Yes
Drer\LOC110438919
3 of 14
No
No
Drer\si:ch211-251b21.1
3 of 14
No
No
Drer\si:dkey-183j2.10
3 of 14
No
No
Drer\grin1a
2 of 14
No
No
Drer\grin1b
2 of 14
No
No
Drer\grin2aa
2 of 14
No
No
Drer\grin2da
2 of 14
No
No
Drer\grin3bb
2 of 14
No
Yes
Drer\LOC100149482
2 of 14
No
No
Drer\LOC100331381
2 of 14
No
No
Drer\grin2ab
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\glr-1
13 of 14
Yes
Yes
Cele\glr-2
11 of 14
No
Yes
Cele\glr-3
5 of 14
No
No
Cele\glr-4
5 of 14
No
No
Cele\glr-5
5 of 14
No
No
Cele\glr-6
3 of 14
No
No
Cele\glr-7
3 of 14
No
No
Cele\glr-8
3 of 14
No
Yes
Cele\nmr-1
2 of 14
No
No
Cele\W02A2.5
2 of 14
No
Yes
Cele\C08B6.5
1 of 14
No
No
Cele\F59E12.8
1 of 14
No
No
Cele\gbb-2
1 of 14
No
No
Cele\mgl-2
1 of 14
No
No
Cele\nmr-2
1 of 14
No
No
Cele\spp-22
1 of 14
No
Yes
Cele\T25E4.2
1 of 14
No
No
Cele\ZK867.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (46)
Agam\AgaP_AGAP006027
9 of 12
Yes
No
Agam\AgaP_AGAP000798
4 of 12
No
No
Agam\AgaP_AGAP000803
4 of 12
No
No
Agam\AgaP_AGAP012447
4 of 12
No
No
Agam\AgaP_AGAP000801
3 of 12
No
No
Agam\AgaP_AGAP002797
3 of 12
No
No
Agam\AgaP_AGAP005527
3 of 12
No
Yes
Agam\AgaP_AGAP006026
3 of 12
No
No
Agam\AgaP_AGAP010272
3 of 12
No
No
Agam\AgaP_AGAP010411
3 of 12
No
No
Agam\AgaP_AGAP000256
2 of 12
No
No
Agam\AgaP_AGAP000714
2 of 12
No
No
Agam\AgaP_AGAP001478
2 of 12
No
No
Agam\AgaP_AGAP001811
2 of 12
No
No
Agam\AgaP_AGAP001812
2 of 12
No
No
Agam\AgaP_AGAP002763
2 of 12
No
No
Agam\AgaP_AGAP004923
2 of 12
No
No
Agam\AgaP_AGAP004969
2 of 12
No
No
Agam\AgaP_AGAP007498
2 of 12
No
No
Agam\AgaP_AGAP007951
2 of 12
No
No
Agam\AgaP_AGAP008511
2 of 12
No
No
Agam\AgaP_AGAP009014
2 of 12
No
No
Agam\AgaP_AGAP011943
2 of 12
No
No
Agam\AgaP_AGAP011968
2 of 12
No
No
Agam\AgaP_AGAP012429
2 of 12
No
No
Agam\AgaP_AGAP013154
2 of 12
No
No
Agam\AgaP_AGAP013172
2 of 12
No
No
Agam\AgaP_AGAP013285
2 of 12
No
No
Agam\AgaP_AGAP013363
2 of 12
No
No
Agam\AgaP_AGAP013409
2 of 12
No
No
Agam\AgaP_AGAP013416
2 of 12
No
No
Agam\AgaP_AGAP013520
2 of 12
No
No
Agam\AgaP_AGAP000140
1 of 12
No
No
Agam\AgaP_AGAP000293
1 of 12
No
No
Agam\AgaP_AGAP002904
1 of 12
No
No
Agam\AgaP_AGAP003531
1 of 12
No
No
Agam\AgaP_AGAP004021
1 of 12
No
No
Agam\AgaP_AGAP004432
1 of 12
No
No
Agam\AgaP_AGAP004475
1 of 12
No
No
Agam\AgaP_AGAP005466
1 of 12
No
No
Agam\AgaP_AGAP008759
1 of 12
No
No
Agam\AgaP_AGAP012872
1 of 12
No
No
Agam\AgaP_AGAP012951
1 of 12
No
No
Agam\AgaP_AGAP012969
1 of 12
No
No
Agam\AgaP_AGAP013085
1 of 12
No
No
Agam\GPRGBB3
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\GLR3.4
10 of 13
Yes
Yes
Atha\GLR3.5
10 of 13
Yes
Yes
Atha\GLR5
10 of 13
Yes
Yes
Atha\GLR2
9 of 13
No
No
Atha\GLR3.3
9 of 13
No
No
Atha\GLR3.6
9 of 13
No
No
Atha\GLUR2
9 of 13
No
No
Atha\ATGLR1.2
8 of 13
No
No
Atha\GLR1.1
8 of 13
No
No
Atha\GLR1.3
8 of 13
No
No
Atha\GLR2.1
8 of 13
No
No
Atha\GLR2.2
8 of 13
No
No
Atha\GLR2.3
8 of 13
No
No
Atha\GLR2.4
8 of 13
No
No
Atha\GLR2.5
8 of 13
No
No
Atha\GLR2.6
8 of 13
No
No
Atha\GLR2.7
8 of 13
No
No
Atha\GLR2.8
8 of 13
No
No
Atha\GLR2.9
8 of 13
No
No
Atha\GLR1.4
7 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (1)
Ecol\tcyJ
1 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:GluRIA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (47)
GluRIB
12 of 13
clumsy
9 of 13
Ekar
8 of 13
GluRIID
8 of 13
GluRIIE
8 of 13
Ir25a
8 of 13
KaiR1D
8 of 13
ukar
8 of 13
GluRIIA
7 of 13
Grik
7 of 13
Nmdar1
7 of 13
GluRIIB
6 of 13
Ir8a
6 of 13
GluRIIC
5 of 13
Nmdar2
5 of 13
Ir64a
4 of 13
Ir75a
4 of 13
Ir75c
4 of 13
Ir75d
4 of 13
Ir76b
4 of 13
Ir7c
3 of 13
Ir7d
3 of 13
Ir7e
3 of 13
Ir7f
3 of 13
Ir21a
3 of 13
Ir68a
3 of 13
Ir75b
3 of 13
Ir84a
3 of 13
Ir85a
3 of 13
Ir93a
3 of 13
Ir7a
2 of 13
Ir7b
2 of 13
Ir7g
2 of 13
Ir40a
2 of 13
Ir41a
2 of 13
Ir60a
2 of 13
Ir68b
2 of 13
Ir76a
2 of 13
Ir92a
2 of 13
Ir94d
2 of 13
Ir10a
1 of 13
Ir11a
1 of 13
Ir31a
1 of 13
Ir51b
1 of 13
Ir94a
1 of 13
Ir100a
1 of 13
mtt
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    GluRIAA690V.LcA729T.UAS
    model of  central nervous system disease
    CEA
    (Hamanaka et al., 2022)
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GRIA3; glutamate ionotropic receptor AMPA type subunit 3
    13 of 14
    305915
     
    GRIA1; glutamate ionotropic receptor AMPA type subunit 1
    12 of 14
    138248
     
    GRIA2; glutamate ionotropic receptor AMPA type subunit 2
    12 of 14
    138247
       
      GRIA4; glutamate ionotropic receptor AMPA type subunit 4
      12 of 14
      138246
        GRIK4; glutamate ionotropic receptor kainate type subunit 4
        7 of 14
        600282
            GRIK1; glutamate ionotropic receptor kainate type subunit 1
            6 of 14
            138245
                 
                GRIK3; glutamate ionotropic receptor kainate type subunit 3
                6 of 14
                138243
                    GRIK2; glutamate ionotropic receptor kainate type subunit 2
                    5 of 14
                    138244
                    GRIK5; glutamate ionotropic receptor kainate type subunit 5
                    5 of 14
                    600283
                         
                        GRID1; glutamate ionotropic receptor delta type subunit 1
                        4 of 14
                        610659
                            GRID2; glutamate ionotropic receptor delta type subunit 2
                            3 of 14
                            602368
                            GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B
                            3 of 14
                            138252
                            GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C
                            3 of 14
                            138254
                                GRIN3A; glutamate ionotropic receptor NMDA type subunit 3A
                                3 of 14
                                606650
                                    GRIN3B; glutamate ionotropic receptor NMDA type subunit 3B
                                    3 of 14
                                    606651
                                        Functional Complementation Data
                                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                        Interactions
                                        Summary of Physical Interactions
                                        Interaction Browsers
                                        Summary of Genetic Interactions
                                        Interaction Browsers
                                        View in FlyBase Interactions Browser   View in MIST tool (external link)
                                        Please look at the allele data for full details of the genetic interactions
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        mir-1000
                                        suppressible
                                        GluRIA
                                        (Verma et al., 2015)
                                        External Data
                                        Subunit Structure (UniProtKB)
                                        Homooligomer.
                                        (UniProt, Q03445 )
                                        Linkouts
                                        DroID - A comprehensive database of gene and protein interactions.
                                        Pathways
                                        Signaling Pathways (FlyBase)
                                        Metabolic Pathways
                                        FlyBase
                                        External Links
                                        External Data
                                        Linkouts
                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                        Class of Gene
                                        Genomic Location and Detailed Mapping Data
                                        Chromosome (arm)
                                        3L
                                        Recombination map
                                        3-17
                                        Cytogenetic map
                                        65C1-65C1
                                        Sequence location
                                        FlyBase Computed Cytological Location
                                        Cytogenetic map
                                        Evidence for location
                                        65C1-65C1
                                        Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
                                        Experimentally Determined Cytological Location
                                        Cytogenetic map
                                        Notes
                                        References
                                        65C-65C
                                        (Ultsch, 1992.12.21)
                                        65C-65C
                                        (determined by in situ hybridisation)
                                        (Ultsch et al., 1992)
                                        Experimentally Determined Recombination Data
                                        Location

                                        3-17

                                        (FlyBase, 2016)

                                        3-15.2

                                        (Comeron et al., 2012)
                                        Left of (cM)
                                        Right of (cM)
                                        Notes
                                        Stocks and Reagents
                                        Stocks (95)
                                        Genomic Clones (34)
                                        cDNA Clones (7)
                                         

                                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                        cDNA clones, fully sequenced
                                        BDGP DGC clones
                                        Other clones
                                        Drosophila Genomics Resource Center cDNA clones

                                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                        cDNA Clones, End Sequenced (ESTs)
                                        BDGP DGC clones
                                          Other clones
                                          RNAi and Array Information
                                          Linkouts
                                          DRSC - Results frm RNAi screens
                                          Antibody Information
                                          Laboratory Generated Antibodies
                                           
                                          Commercially Available Antibodies
                                           
                                          Cell Line Information
                                          Publicly Available Cell Lines
                                           
                                            Other Stable Cell Lines
                                             
                                              Other Comments

                                              Glutamate receptor channels in Drosophila embryos and larvae have been studied using the patch-clamp technique.

                                              (Nishikawa and Kidokoro, 1995)

                                              Expression in Xenopus oocytes shows Glu-RI to encode a homo-oligomeric ion channel.

                                              (Ultsch et al., 1992)
                                              Relationship to Other Genes
                                              Source for database merge of
                                              Additional comments
                                              Nomenclature History
                                              Source for database identify of

                                              Source for identity of: Glu-RI CG8442

                                              (Gabrielian, 1999.11)

                                              Source for identity of: GluRIA Glu-RI

                                              (FlyBase, 2009-)
                                              Nomenclature comments

                                              'Glu-RI' renamed to 'GluRIA' for the following reasons: i) It makes sense to give this gene an 'A' suffix to match the 'B' suffix already used for the related gene 'GluRIB'. This follows the nomenclature used in FBrf0130145 and is consistent with the naming convention used for GluRII genes; ii) The hyphen is unnecessary and removing it matches the nomenclature of other GluR genes.

                                              (FlyBase, 2009-)
                                              Etymology
                                              Synonyms and Secondary IDs (21)
                                              Reported As
                                              Symbol Synonym
                                              CG8442
                                              (Mao et al., 2024, Hu et al., 2015, Tsubouchi et al., 2012, Croset et al., 2010, Ni et al., 2010.12.1, Benton et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009)
                                              DGluR-I
                                              (Schmitt et al., 1993, Schuster et al., 1993, Ultsch et al., 1993, Schuster et al., 1991)
                                              DGluR-IA
                                              (Volkner et al., 2000)
                                              DGluRI
                                              (Marrus et al., 2004)
                                              DmelGlu-R1
                                              (Croset et al., 2010)
                                              Dro GluRIA
                                              (Walker et al., 2006)
                                              Glu-R1
                                              (Chung et al., 2011, Croset et al., 2010, Benton et al., 2009)
                                              Glu-RI
                                              (Al-Ramahi et al., 2018, Crocker et al., 2016, Sarov et al., 2016, Tsubouchi et al., 2012, Stagg et al., 2011, Wheeler et al., 2006, Yepiskoposyan et al., 2006)
                                              GluR1
                                              (Lei et al., 2017, Jayakumar et al., 2016, Verma et al., 2015)
                                              GluR1A
                                              (Deng et al., 2019)
                                              GluRI
                                              (Lee et al., 2009)
                                              GluRIA
                                              (Pollex et al., 2024, Qu et al., 2024, Soares et al., 2024, Bossen et al., 2023, Praschberger et al., 2023, Deshpande et al., 2022, Greco et al., 2022, Baker et al., 2021, Li et al., 2021, Salim et al., 2021, Kurmangaliyev et al., 2020, Mazzotta et al., 2020, Deng et al., 2019, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Schwartz et al., 2016, Hu et al., 2015, Walker et al., 2006)
                                              GluRIIA
                                              (Sebastian et al., 2022, Frank et al., 2020)
                                              dGluRI
                                              (Ma et al., 2001)
                                              dglur-IA
                                              (Volkner et al., 2000)
                                              Name Synonyms
                                              Glutamate receptor I
                                              (Tsubouchi et al., 2012, Chung et al., 2011)
                                              Glutamate receptor IA
                                              glutamate receptor
                                              (Verstreken and Bellen, 2002, Chang et al., 1993)
                                              glutamate receptor kainate-selective subunit
                                              (Ultsch, 1992.12.21)
                                              glutamate receptor subunit
                                              (Mukherjee et al., 2020)
                                              kainate receptor
                                              (Chiang et al., 2002)
                                              Secondary FlyBase IDs
                                                Datasets (0)
                                                Study focus (0)
                                                Experimental Role
                                                Project
                                                Project Type
                                                Title
                                                Study result (0)
                                                Result
                                                Result Type
                                                Title
                                                External Crossreferences and Linkouts ( 45 )
                                                Sequence Crossreferences
                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                Other crossreferences
                                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                FlyMine - An integrated database for Drosophila genomics
                                                InterPro - A database of protein families, domains and functional sites
                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                                PDB - An information portal to biological macromolecular structures
                                                Linkouts
                                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                DroID - A comprehensive database of gene and protein interactions.
                                                DRSC - Results frm RNAi screens
                                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                Flygut - An atlas of the Drosophila adult midgut
                                                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                References (94)