FB2026_03 , released September 17, 2026
CV Term Report
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Term modulation of chemical synaptic transmission ID (Ontology) GO:0050804 (Gene Ontology)
Definition Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
Also Known As"regulation of chemical synaptic transmission" ; "regulation of synaptic transmission"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 modulation of chemical synaptic transmission (all annotations which use CV term, excluding "NOT" statements)
     involved_in | modulation of chemical synaptic transmission
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regulation of cell communication
 |__regulation of trans-synaptic signaling__
regulation of signaling                     |
 |__regulation of trans-synaptic signaling__|
anterograde trans-synaptic signaling        |
 |__chemical synaptic transmission__________|
trans-synaptic signaling                    |
 |__regulation of trans-synaptic signaling__|
                                            modulation of chemical synaptic transmission  160 rec.
                                             |__modulation of excitatory postsynaptic potential 1 rec.
                                             |   |__negative regulation of excitatory postsynaptic potential(+)
                                             |   |__positive regulation of excitatory postsynaptic potential(+)
                                             |   |__regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1 rec.
                                             |   |__regulation of mini excitatory postsynaptic potential(+)
                                             |__negative regulation of synaptic transmission 18 rec.
                                             |   |__long-term synaptic depression(+) 1 rec.
                                             |   |__negative regulation of neuromuscular synaptic transmission 11 rec.
                                             |   |__negative regulation of synaptic transmission, cholinergic(+) 1 rec.
                                             |   |__negative regulation of synaptic transmission, dopaminergic
                                             |   |__negative regulation of synaptic transmission, GABAergic 1 rec.
                                             |   |__negative regulation of synaptic transmission, glutamatergic(+) 1 rec.
                                             |   |__negative regulation of synaptic transmission, glycinergic(+)
                                             |__positive regulation of synaptic transmission 24 rec.
                                             |   |__long-term strengthening of neuromuscular junction 2 rec.
                                             |   |__long-term synaptic potentiation(+) 1 rec.
                                             |   |__negative regulation of long-term synaptic depression
                                             |   |__positive regulation of long-term synaptic potentiation
                                             |   |__positive regulation of neuromuscular synaptic transmission 8 rec.
                                             |   |__positive regulation of neurotransmitter secretion(+) 6 rec.
                                             |   |__positive regulation of synaptic transmission, cholinergic(+) 3 rec.
                                             |   |__positive regulation of synaptic transmission, dopaminergic 2 rec.
                                             |   |__positive regulation of synaptic transmission, GABAergic 1 rec.
                                             |   |__positive regulation of synaptic transmission, glutamatergic(+) 4 rec.
                                             |   |__positive regulation of synaptic transmission, glycinergic(+)
                                             |__postsynaptic modulation of chemical synaptic transmission
                                             |   |__regulation of protein catabolic process at postsynapse, modulating synaptic transmission
                                             |   |__regulation of translation at postsynapse, modulating synaptic transmission
                                             |__presynaptic modulation of chemical synaptic transmission 5 rec.
                                             |   |__induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
                                             |   |__regulation of presynaptic dense core granule exocytosis 1 rec.
                                             |   |__regulation of protein catabolic process at presynapse, modulating synaptic transmission
                                             |   |__regulation of translation at presynapse, modulating synaptic transmission 2 rec.
                                             |__regulation of modification of synapse structure, modulating synaptic transmission
                                             |__regulation of neuromuscular synaptic transmission 29 rec.
                                             |   |__negative regulation of neuromuscular synaptic transmission 11 rec.
                                             |   |__positive regulation of neuromuscular synaptic transmission 8 rec.
                                             |__regulation of neurotransmitter secretion 34 rec.
                                             |   |__negative regulation of neurotransmitter secretion(+) 3 rec.
                                             |   |__positive regulation of neurotransmitter secretion(+) 6 rec.
                                             |   |__regulation of acetylcholine secretion, neurotransmission(+)
                                             |   |__regulation of glutamate secretion, neurotransmission(+) 5 rec.
                                             |   |__regulation of glycine secretion, neurotransmission(+)
                                             |   |__regulation of spontaneous neurotransmitter secretion(+)
                                             |   |__regulation of substance P secretion, neurotransmission(+)
                                             |   |__regulation of synaptic vesicle exocytosis(+) 11 rec.
                                             |__regulation of protein catabolic process at synapse, modulating synaptic transmission
                                             |__regulation of spontaneous synaptic transmission
                                             |   |__regulation of spontaneous neurotransmitter secretion(+)
                                             |__regulation of synaptic activity 16 rec.
                                             |__regulation of synaptic plasticity 36 rec.
                                             |   |__long-term synaptic depression(+) 1 rec.
                                             |   |__long-term synaptic potentiation(+) 1 rec.
                                             |   |__negative regulation of synaptic plasticity(+)
                                             |   |__positive regulation of synaptic plasticity(+) 1 rec.
                                             |   |__regulation of long-term synaptic depression(+)
                                             |   |__regulation of long-term synaptic potentiation(+)
                                             |   |__regulation of neuronal synaptic plasticity(+) 15 rec.
                                             |   |__regulation of short-term synaptic potentiation(+)
                                             |   |__regulation of synaptic metaplasticity(+)
                                             |   |__regulation of synaptic plasticity by chemical substance(+)
                                             |   |__regulation of synaptic scaling
                                             |   |__short-term synaptic potentiation(+)
                                             |__regulation of synaptic transmission, cholinergic 22 rec.
                                             |   |__negative regulation of synaptic transmission, cholinergic(+) 1 rec.
                                             |   |__positive regulation of synaptic transmission, cholinergic(+) 3 rec.
                                             |   |__regulation of acetylcholine secretion, neurotransmission(+)
                                             |__regulation of synaptic transmission, dopaminergic 3 rec.
                                             |   |__negative regulation of synaptic transmission, dopaminergic
                                             |   |__positive regulation of synaptic transmission, dopaminergic 2 rec.
                                             |__regulation of synaptic transmission, GABAergic 2 rec.
                                             |   |__negative regulation of synaptic transmission, GABAergic 1 rec.
                                             |   |__positive regulation of synaptic transmission, GABAergic 1 rec.
                                             |__regulation of synaptic transmission, glutamatergic 9 rec.
                                             |   |__negative regulation of synaptic transmission, glutamatergic(+) 1 rec.
                                             |   |__positive regulation of synaptic transmission, glutamatergic(+) 4 rec.
                                             |   |__regulation of glutamate secretion, neurotransmission(+) 5 rec.
                                             |__regulation of synaptic transmission, glycinergic
                                             |   |__negative regulation of synaptic transmission, glycinergic(+)
                                             |   |__positive regulation of synaptic transmission, glycinergic(+)
                                             |   |__regulation of glycine secretion, neurotransmission(+)
                                             |__regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
                                             |__regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
                                             |__regulation of translation at synapse, modulating synaptic transmission 2 rec.
                                             |   |__regulation of translation at postsynapse, modulating synaptic transmission
                                             |   |__regulation of translation at presynapse, modulating synaptic transmission 2 rec.
                                             |__rhythmic synaptic transmission 2 rec.
                                             |   |__rhythmic excitation 1 rec.
                                             |   |__rhythmic inhibition
                                             |__trans-synaptic signaling, modulating synaptic transmission
                                                 |__trans-synaptic signaling by BDNF, modulating synaptic transmission(+)
                                                 |__trans-synaptic signaling by lipid, modulating synaptic transmission(+)
                                                 |__trans-synaptic signaling by neuropeptide, modulating synaptic transmission(+)
                                                 |__trans-synaptic signaling by soluble gas, modulating synaptic transmission(+)
                                                 |__trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
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Is a regulation of trans-synaptic signaling
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Synonyms
  • "modulation of synaptic transmission" BROAD
    "regulation of chemical synaptic transmission" EXACT
    "regulation of synaptic transmission" EXACT
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