FlyBase Gene Report: Dmel\Ir93a

General Information

Symbol

Dmel\Ir93a

Species

D. melanogaster

Name

Ionotropic receptor 93a

Annotation Symbol

CG42315

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259215

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation) and humidity (hygrosensation) (PubMed:27161501, PubMed:27656904). Together with Ir21a and Ir25a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27161501, PubMed:27656904). Together with Ir25a and Ir40a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904). (UniProt, Q9VDH6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

93A2-93A2

Sequence location

3R:20,851,709..20,859,945 [-]

Recombination map

3-69

RefSeq locus

NT_033777 REGION:20851709..20859945

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

enables ligand-gated monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception

inferred from expression pattern

(Benton et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

involved_in synaptic transmission, glutamatergic

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

is_active_in postsynaptic density membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS

Protein Family (UniProt)

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q9VDH6)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ANTENNAL IONOTROPIC CO-RECEPTORS -: Ionotropic Receptors (IR) co-receptors are part of the IR family. They are broadly, but selectively, expressed in antennal sensory neurons in Drosophila. Some antenneal IRs only form functional odor-responsive ion channels as a heteromeric complex with an IR co-receptor. (Adapted from FBrf0222310).

Protein Function (UniProtKB)

(UniProt, Q9VDH6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir93a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VDH6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.48

Evidence supports alternative transcription start site within intronic TE (RAMPAGE TSS data, FBrf0220331; RNA-Seq data). May be specific to sequenced strain; not included in gene model.

Mutation in sequenced strain: insertion of transposon.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir93a-RD

FBtr0336970

NM_142667

2742

868

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ir93a-PD

FBpp0307913

99.6

868

6.22

Q9VDH6

NP_650924

AAF55817

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VDH6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir93a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir93a_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.42

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic head sensory system

(Fisher et al., 2012)

adult stage

sacculus | restricted

Comment: neurons surrounding the first and second chambers of the sacculus

(Benton et al., 2009)

neuron of coeloconic sensillum of antennal segment 3

(Benton et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antenna

(Croset et al., 2010)

Additional Descriptive Data

Ir93a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 adjacent to the chambers I and II of the sacculus.

(Benton et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

antennal lobe glomerulus VP5

(Knecht et al., 2017)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

dorsal organ cool cell

• dendrite terminus

(Knecht et al., 2016)

adult stage

adult hygrosensory neuron Ir40a

(Knecht et al., 2016)

aristal sensory neuron VP3

(Budelli et al., 2019)

aristal sensory neuron VP2

(Budelli et al., 2019)

Additional Descriptive Data

Ir93a protein is detected in cold cell sensory endings. It is also detected in hot cells.

(Budelli et al., 2019)

Ir93a is expressed in dorsal organ cool cells marked by expression driven by ScerGAL4^Ir21a.PK and localizes prominently to the dendritic bulb at the tip of the sensory processes. It is also expressed in Ir25a and Ir40a positive adult olfactory receptor neuron Ir40a.

(Knecht et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir93a-GAL4.237}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gustatory receptor neuron of the dorsal organ

(Sánchez-Alcañiz et al., 2018)

adult stage

adult antennal olfactory receptor neuron | subset

(Sánchez-Alcañiz et al., 2018)

Reporter: P{Ir93a-lexA.U}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

chamber I of sacculus | restricted

(Frank et al., 2017)

chamber II of sacculus | restricted

(Frank et al., 2017)

aristal sensory neuron VP2

(Frank et al., 2017)

aristal sensory neuron VP3

(Frank et al., 2017)

Reporter: P{VT044927-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

superior lateral protocerebrum

(Jefferis, 2016.3.4)

antennal mechanosensory and motor center

(Jefferis, 2016.3.4)

superior medial protocerebrum

(Jefferis, 2016.3.4)

adult antennal lobe

(Jefferis, 2016.3.4)

adult lateral accessory lobe

(Jefferis, 2016.3.4)

adult lateral horn

(Jefferis, 2016.3.4)

adult hygrosensory neuron Ir68a

(Sun et al., 2018)

adult hygrosensory neuron Ir40a VP4

(Sun et al., 2018)

chamber II of sacculus

(Sun et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ir93a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir93a

View exonic expression by tissue for Dmel\Ir93a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259215

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42471/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259215

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259215

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259215

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17274

Flygut - An atlas of the Drosophila adult midgut

FBgn0259215

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir93a

Transgenic constructs containing regulatory region of Ir93a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Ir93a^KK103661

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\GRIA1

3 of 14

Yes

Hsap\GRIA2

3 of 14

Yes

Hsap\GRIA3

3 of 14

Yes

Hsap\GRIA4

3 of 14

Yes

Hsap\GRIK4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Gria1

3 of 14

Yes

Rnor\Gria2

3 of 14

Yes

Rnor\Gria3

3 of 14

Yes

Rnor\Gria4

3 of 14

Yes

Rnor\Grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Gria1

3 of 14

Yes

Mmus\Gria2

3 of 14

Yes

Mmus\Gria4

3 of 14

Yes

Mmus\Grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\grik4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gmpr

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lrfn5

1 of 13

Xtro\lrrn4cl

1 of 13

Yes

Xtro\mettl4

1 of 13

Xtro\vtcn1

1 of 13

Yes

Danio rerio (Zebrafish) (32)

Drer\gria1a

3 of 14

Yes

Drer\gria1b

3 of 14

Yes

Drer\gria2a

3 of 14

Yes

Drer\gria2b

3 of 14

Yes

Drer\gria3a

3 of 14

Yes

Drer\gria3b

3 of 14

Yes

Drer\gria4a

3 of 14

Yes

Drer\gria4b

3 of 14

Yes

Drer\grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-251b21.1

1 of 14

Drer\si:dkey-183j2.10

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\glr-1

2 of 14

Yes

Cele\glr-2

2 of 14

Yes

Cele\glr-3

2 of 14

Yes

Cele\glr-4

2 of 14

Yes

Cele\glr-5

2 of 14

Yes

Cele\glr-6

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (34)

Agam\AgaP_AGAP000256

10 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR2.1

2 of 13

Yes

Atha\GLR2.2

2 of 13

Yes

Atha\GLR2.3

2 of 13

Yes

Atha\GLR2.5

2 of 13

Yes

Atha\GLR2.6

2 of 13

Yes

Atha\GLR2.7

2 of 13

Yes

Atha\GLR2.8

2 of 13

Yes

Atha\GLR2.9

2 of 13

Yes

Atha\GLR2

2 of 13

Yes

Atha\GLR3.3

2 of 13

Yes

Atha\GLR3.4

2 of 13

Yes

Atha\GLR3.5

2 of 13

Yes

Atha\GLR3.6

2 of 13

Yes

Atha\GLR5

2 of 13

Yes

Atha\GLUR2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ir93a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (43)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

model of autosomal dominant intellectual developmental disorder 67

IEA

(FlyBase, 2019-)

model of autosomal recessive intellectual developmental disorder 76

IEA

(FlyBase, 2019-)

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

model of syndromic X-linked intellectual disability 94

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

3 of 14

138248

GRIA2; glutamate ionotropic receptor AMPA type subunit 2

3 of 14

138247

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND BEHAVIORAL ABNORMALITIES; NEDLIB

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

3 of 14

305915

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, WU TYPE; MRXSW

syndromic X-linked intellectual disability 94

GRIA4; glutamate ionotropic receptor AMPA type subunit 4

3 of 14

138246

NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT SEIZURES AND GAIT ABNORMALITIES; NEDSGA

GRIK4; glutamate ionotropic receptor kainate type subunit 4

3 of 14

600282

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259215

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-69

Cytogenetic map

93A2-93A2

Sequence location

3R:20,851,709..20,859,945 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93A2-93A2

Limits computationally determined from genome sequence between P{EP}Synd^EP409 and P{lacW}l(3)j5C7^j5C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-69

(FlyBase, 2016)

3-73.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24810

w¹¹¹⁸; Mi{ET1}Ir93a^MB04433

63700

y¹ v¹; P{TRiP.HMJ30268}attP40

42090

y¹ w^*; Mi{MIC}Ir93a^MI05555

84075

y¹ v¹; P{TKO.GS05544}attP2/TM3 Sb¹

58887

w^*; TI{TI}mir-1011^KO Ir93a^mir-1011-KO/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb¹ Ser¹

NIG-Fly

HMJ30268

y¹ v¹; P{TRiP.HMJ30268}attP40/CyO

VDRC

v100837

P{KK103661}VIE-260B

v102983

P{KK112981}VIE-260B

v342345

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02146}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH01149

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259215

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Knecht et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17274 CG17275

(FlyBase Genome Annotators, 2008)

Additional comments

Annotations CG17274 and CG17275 merged as CG42315 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

One of the introns of CG17274 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG17274 intron is mir-1011.

(Ruby et al., 2007)

Nomenclature History

Source for database identify of

Source for identity of: Ir93a CG42315

(Benton et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

93a

(Ni, 2020)

CG17274

(Keleman et al., 2009.8.5, Lee et al., 2009, Ruby et al., 2007, Lipatov et al., 2005)

CG17275

(Glittenberg et al., 2022, Keleman et al., 2009.8.5, Lee et al., 2009)

CG42315

(Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Perkins et al., 2009, FlyBase Genome Annotators, 2008)

CT35907

(Littleton and Ganetzky, 2000)

DmelIR93a

(Croset et al., 2010)

IR93

(Liu and Zhang, 2022)

IR93a

(Liu and Zhang, 2022, George and Stanewsky, 2021, Montell, 2021, Xiao and Xu, 2021, Ni, 2020, Lei et al., 2019, Gomez-Diaz et al., 2018, Rimal and Lee, 2018, Knecht et al., 2017, Transgenic RNAi Project members, 2017-, Menuz et al., 2014, Silbering et al., 2011, Croset et al., 2010, Benton et al., 2009)

Ir93

(Budelli et al., 2025)

Ir93a

(Asefa et al., 2024, Suito and Tominaga, 2024, Corthals et al., 2023, Ali et al., 2022, Huda et al., 2022, McLaughlin et al., 2021, Pang et al., 2021, Li et al., 2020, Budelli et al., 2019, Mossman et al., 2019, Frank et al., 2017, Ganguly et al., 2017, Crocker et al., 2016, Enjin et al., 2016, Knecht et al., 2016, Chen et al., 2014, Catalán et al., 2012, Tsubouchi et al., 2012)

ir93a

(Riveron et al., 2013)

Name Synonyms

CG17274

CG17275

CG42315

(FlyBase Genome Annotators, 2008)

Ionotropic receptor 93a

(Tsubouchi et al., 2012)

ionotropic receptor 93a

(Benton et al., 2009)

Secondary FlyBase IDs

FBgn0038835
FBgn0038836

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42471

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VDH6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VDH6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VDH6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259215

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42471/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0259215

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0259215

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42315

MARRVEL_MODEL - MARRVEL (model organism gene)

42471

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0259215

DRSC - Results frm RNAi screens

FBgn0259215

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir93a_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259215

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0259215

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17274

Flygut - An atlas of the Drosophila adult midgut

FBgn0259215

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0259215

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000374

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (76)

The following external sites may use different assemblies or annotations than FlyBase.

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