FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ligand-gated monoatomic ion channel activity ID (Ontology) GO:0015276 (Gene Ontology)
Definition Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.[ ISBN:0815340729 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ligand-gated monoatomic ion channel activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ligand-gated monoatomic ion channel activity       --
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monoatomic ion transmembrane transporter activity
 |__monoatomic ion channel activity__
channel activity                     |
 |__monoatomic ion channel activity__|
gated channel activity               |
 |__ligand-gated channel activity____|
                                     ligand-gated monoatomic ion channel activity  297 rec.
                                      |__cyclic nucleotide-activated monoatomic ion channel activity 7 rec.
                                      |   |__intracellularly cyclic nucleotide-activated monoatomic cation channel activity(+) 7 rec.
                                      |__extracellular ligand-gated monoatomic ion channel activity 53 rec.
                                      |   |__excitatory extracellular ligand-gated monoatomic ion channel activity(+) 22 rec.
                                      |   |__extracellular ammonia-gated monoatomic ion channel activity 1 rec.
                                      |   |__extracellular phenylacetaldehyde-gated monoatomic ion channel activity 2 rec.
                                      |   |__inhibitory extracellular ligand-gated monoatomic ion channel activity(+)
                                      |   |__transmitter-gated monoatomic ion channel activity(+) 43 rec.
                                      |__intracellularly ligand-gated monoatomic ion channel activity 15 rec.
                                      |   |__intracellularly ATP-gated ion channel activity(+)
                                      |   |__intracellularly cyclic nucleotide-activated monoatomic cation channel activity(+) 7 rec.
                                      |   |__intracellularly gated calcium channel activity(+) 7 rec.
                                      |   |__intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity 1 rec.
                                      |__ionotropic olfactory receptor activity 60 rec.
                                      |__ionotropic taste receptor activity 16 rec.
                                      |   |__ionotropic bitter taste receptor activity 1 rec.
                                      |   |__ionotropic salty taste receptor activity 1 rec.
                                      |   |__ionotropic sweet taste receptor activity 10 rec.
                                      |__ligand-gated monoatomic anion channel activity 20 rec.
                                      |   |__extracellularly glutamate-gated chloride channel activity 2 rec.
                                      |   |__extracellularly glycine-gated chloride channel activity
                                      |   |__GABA-gated chloride ion channel activity 4 rec.
                                      |   |__glycine-gated chloride ion channel activity 3 rec.
                                      |   |__intracellularly ATP-gated chloride channel activity
                                      |   |__intracellularly calcium-gated chloride channel activity 8 rec.
                                      |   |__pH-gated chloride channel activity 6 rec.
                                      |   |__serotonin-gated chloride channel activity
                                      |__ligand-gated monoatomic cation channel activity 94 rec.
                                      |   |__acetylcholine-gated monoatomic cation-selective channel activity 12 rec.
                                      |   |__calcium-activated cation channel activity(+) 10 rec.
                                      |   |__chloride-activated potassium channel activity
                                      |   |__extracellularly ATP-gated monoatomic cation channel activity
                                      |   |__glycine betaine-activated nonselective monoatomic cation channel activity
                                      |   |__glycine-gated cation channel activity
                                      |   |__intracellular sodium-activated potassium channel activity 2 rec.
                                      |   |__intracellularly cyclic nucleotide-activated monoatomic cation channel activity(+) 7 rec.
                                      |   |__intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity 1 rec.
                                      |   |__inward rectifier potassium channel activity(+) 5 rec.
                                      |   |__ligand-gated calcium channel activity(+) 19 rec.
                                      |   |__ligand-gated sodium channel activity(+) 41 rec.
                                      |   |__mitochondrial ATP-gated potassium channel activity
                                      |   |__serotonin-gated monoatomic cation channel activity
                                      |__ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
                                      |__pH-gated monoatomic ion channel activity 10 rec.
                                          |__pH-gated calcium channel activity 1 rec.
                                          |__pH-gated chloride channel activity 6 rec.
                                          |__pH-gated sodium channel activity 1 rec.
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Is a monoatomic ion channel activity
ligand-gated channel activity
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Synonyms
  • "ionotropic receptor activity" NARROW
    "ligand-gated ion channel activity" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-451310 "Activation of Edited Kainate receptors"
Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors"
Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors"
Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors"
Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors"