FlyBase Gene Report: Dmel\KaiR1D

General Information

Symbol

Dmel\KaiR1D

Species

D. melanogaster

Name

Kainate-type ionotropic glutamate receptor subunit 1D

Annotation Symbol

CG3822

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038837

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength (Interactive Fly, KaiR1D )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DKaiR1D

Key Links

Genomic Location

Cytogenetic map

93A2-93A2

Sequence location

3R:20,860,187..20,866,231 [-]

Recombination map

3-69

RefSeq locus

NT_033777 REGION:20860187..20866231

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (21 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables glutamate-gated calcium ion channel activity

inferred from mutant phenotype

(Kiragasi et al., 2017)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

enables kainate selective glutamate receptor activity

inferred from sequence or structural similarity with UniProtKB:P39086

(Gene Ontology Curators, 2002-)

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables ligand-gated monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594

(InterPro Project Members, 2004-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

enables signaling receptor activity

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in calcium ion import across plasma membrane

inferred from mutant phenotype

(Kiragasi et al., 2017)

acts_upstream_of positive regulation of glutamate secretion, neurotransmission

inferred from mutant phenotype

(Kiragasi et al., 2020)

involved_in positive regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Kiragasi et al., 2017)

involved_in positive regulation of synaptic transmission, glutamatergic

inferred from mutant phenotype

(Kiragasi et al., 2020)

involved_in presynaptic modulation of chemical synaptic transmission

inferred from mutant phenotype

(Kiragasi et al., 2020)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR001508

(InterPro Project Members, 2004-)

involved_in regulation of synaptic activity

inferred from sequence or structural similarity with FLYBASE:GluRIIA; FB:FBgn0004620

(Gene Ontology Curators, 2002-)

involved_in synaptic transmission, glutamatergic

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in presynaptic active zone

inferred from direct assay

(Kiragasi et al., 2017)

located_in presynaptic membrane

inferred from mutant phenotype

(Kiragasi et al., 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:GluRIIA; FB:FBgn0004620

(Gene Ontology Curators, 2002-)

is_active_in postsynaptic density membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

UNCLASSIFIED NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS -: This group comprises ionotropic glutamate receptors which are not selectively activated by NMDA and do not fall into the GluRII sub-type expressed at the neuromuscular junction. (Adapted from FBrf0209026.)

Summary (Interactive Fly)

glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\KaiR1D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VDH5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

KaiR1D-RA

FBtr0083987

NM_142668

3607

853

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

KaiR1D-PA

FBpp0083391

95.9

853

7.73

Q9VDH5

NP_650925

AAF55818

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\KaiR1D using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG3822_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

transmedullary neuron Tm5c

(Karuppudurai et al., 2014)

Additional Descriptive Data

Quantitative RT-PCR on single GFP-labeled cells showed a low level of KaiR1D^JF01873 expression in transmedullary neuron Tm5c compared to the transcript level of VGlut1 in these cells.

(Karuppudurai et al., 2014)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in presynaptic active zone

inferred from direct assay

(Kiragasi et al., 2017)

located_in presynaptic membrane

inferred from mutant phenotype

(Kiragasi et al., 2020)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\KaiR1D in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\KaiR1D

View exonic expression by tissue for Dmel\KaiR1D

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42473/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038837

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3822

Flygut - An atlas of the Drosophila adult midgut

FBgn0038837

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of KaiR1D

Transgenic constructs containing regulatory region of KaiR1D

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

KaiR1D^f03502

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

KaiR1D^GD3677

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

KaiR1D^GD3677

viable, with Scer\GAL4^pnr-MD237

KaiR1D^GD3677

Sterility

Allele

fertile

KaiR1D^f03502

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage

abnormal neurophysiology | larval stage

abnormal neurophysiology | third instar larval stage

KaiR1D^MB01010

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | larval stage

KaiR1D^MB01010

embryonic/larval neuromuscular junction | third instar larval stage

KaiR1D^MB01010

muscle cell of A1-7 ventral longitudinal muscle 3 | third instar larval stage

KaiR1D^MB01010

NMJ bouton | larval stage

KaiR1D^f03502

presynaptic active zone | larval stage

KaiR1D^f03502

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\GRIK1

10 of 14

Yes

Hsap\GRIK2

10 of 14

Yes

Hsap\GRIK3

10 of 14

Yes

8 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Grik2

11 of 14

Yes

Rnor\Grik3

10 of 14

Yes

Rnor\Grik1

9 of 14

Yes

8 of 14

7 of 14

6 of 14

6 of 14

5 of 14

5 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Grik1

10 of 14

Yes

Mmus\Grik2

10 of 14

Yes

Mmus\Grik3

9 of 14

Yes

8 of 14

7 of 14

6 of 14

6 of 14

6 of 14

6 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (26)

Xtro\grik3

8 of 13

Yes

Xtro\grik2

6 of 13

Yes

Xtro\grik1

5 of 13

Yes

Xtro\grik4

5 of 13

Yes

5 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\grm5

1 of 13

Xtro\grm7

1 of 13

Xtro\LOC100496766

1 of 13

Yes

Xtro\npr3

1 of 13

Xtro\serpinb1

1 of 13

Danio rerio (Zebrafish) (33)

Drer\grik1a

10 of 14

Yes

Drer\grik2

10 of 14

Yes

Drer\LOC100334689

10 of 14

Yes

Drer\grik1b

9 of 14

Yes

8 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\si:ch211-251b21.1

3 of 14

Drer\si:dkey-183j2.10

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (22)

Cele\glr-5

10 of 14

Yes

Cele\glr-3

8 of 14

Yes

Cele\glr-4

8 of 14

Yes

Cele\glr-1

6 of 14

Cele\glr-2

5 of 14

Cele\glr-6

4 of 14

Yes

Cele\glr-7

3 of 14

Cele\glr-8

3 of 14

Yes

Cele\C08B6.5

2 of 14

Yes

Cele\nmr-1

2 of 14

Cele\W02A2.5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\T25E4.2

1 of 14

Cele\ZK867.2

1 of 14

Anopheles gambiae (African malaria mosquito) (50)

Agam\AgaP_AGAP000801

10 of 12

Yes

6 of 12

6 of 12

5 of 12

4 of 12

4 of 12

3 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR2

10 of 13

Yes

Atha\GLR3.3

10 of 13

Yes

Atha\GLR3.4

10 of 13

Yes

Atha\GLR3.5

10 of 13

Yes

Atha\GLR3.6

10 of 13

Yes

Atha\GLR5

10 of 13

Yes

Atha\GLUR2

10 of 13

Yes

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:KaiR1D. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (56)

9 of 13

9 of 13

9 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

5 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mtt

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GRIK2; glutamate ionotropic receptor kainate type subunit 2

model of autosomal recessive intellectual developmental disorder 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIK1; glutamate ionotropic receptor kainate type subunit 1

10 of 14

138245

GRIK2; glutamate ionotropic receptor kainate type subunit 2

10 of 14

138244

autosomal recessive intellectual developmental disorder 6

GRIK3; glutamate ionotropic receptor kainate type subunit 3

10 of 14

138243

GRIK4; glutamate ionotropic receptor kainate type subunit 4

8 of 14

600282

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

6 of 14

138248

GRIA2; glutamate ionotropic receptor AMPA type subunit 2

6 of 14

138247

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND BEHAVIORAL ABNORMALITIES; NEDLIB

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

6 of 14

305915

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, WU TYPE; MRXSW

syndromic X-linked intellectual disability 94

GRIA4; glutamate ionotropic receptor AMPA type subunit 4

6 of 14

138246

NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT SEIZURES AND GAIT ABNORMALITIES; NEDSGA

GRIK5; glutamate ionotropic receptor kainate type subunit 5

6 of 14

600283

GRID1; glutamate ionotropic receptor delta type subunit 1

3 of 14

610659

GRID2; glutamate ionotropic receptor delta type subunit 2

3 of 14

602368

SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18; SCAR18

autosomal recessive spinocerebellar ataxia 18

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

KaiR1D - miso

anti tag coimmunoprecipitation, reverse transcription pcr

(Li et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

KaiR1D

enhanceable

VGlut1

(Kiragasi et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

GluRIIA

suppressible

KaiR1D

(Kiragasi et al., 2017)

Sol1

suppressible

KaiR1D

(Kiragasi et al., 2020)

VGlut1

enhanceable

KaiR1D

(Kiragasi et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038837

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-69

Cytogenetic map

93A2-93A2

Sequence location

3R:20,860,187..20,866,231 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93A2-93A2

Limits computationally determined from genome sequence between P{EP}Synd^EP409 and P{lacW}l(3)j5C7^j5C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-69

(FlyBase, 2016)

3-73.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18663

w¹¹¹⁸; PBac{WH}KaiR1D^f03502

25852

y¹ v¹; P{TRiP.JF01873}attP2

22962

y¹ w^67c23; Mi{ET1}KaiR1D^MB01010

98475

y¹ w^*; TI{CRIMIC.TG4.1}KaiR1D^{CR02985-TG4.1}/TM3, Sb¹ Ser¹

VDRC

v110201

P{KK102490}VIE-260B

v40985

w¹¹¹⁸ P{GD3677}v40985

v342961

P{hsFLP}1, y1 w1118; P{HD_CFD02529}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (63)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE06730

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038837

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038837

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kiragasi et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: KaiR1D CG3822

(Kiragasi et al., 2017)

Nomenclature comments

Etymology

The gene is named 'KaiR1D' based on function and phylogenetic analysis.

(Kiragasi et al., 2017)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG3822

(Mao et al., 2024, Kondo et al., 2020, Deng et al., 2019, Kiragasi et al., 2017, Hu et al., 2015, Tsubouchi et al., 2012, Guan et al., 2011, Croset et al., 2010, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Lee et al., 2009, Perkins et al., 2009.1.15)

CT12759

(Littleton and Ganetzky, 2000)

DKaiR1D

(Wenner and Pekala, 2022, Li et al., 2021, Kiragasi et al., 2020, Kiragasi et al., 2017)

DKaiRID

(Karuppudurai et al., 2014)

DmelCG3822

(Croset et al., 2010)

KaiR1D

(Titus et al., 2023, Han et al., 2020, Kondo et al., 2020, Li et al., 2020, Gene Disruption Project members, 2018-)

KaiRID

(Han et al., 2020)

dKaiR1D

(Frank et al., 2020)

Name Synonyms

Kainate-type ionotropic glutamate receptor subunit 1D

kainate-type ionotropic glutamate receptor subunit 1D

(Nair et al., 2021)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42473

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VDH5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VDH5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42473/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038837

FlyMine - An integrated database for Drosophila genomics

FBgn0038837

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3822

MARRVEL_MODEL - MARRVEL (model organism gene)

42473

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038837

DroID - A comprehensive database of gene and protein interactions.

FBgn0038837

DRSC - Results frm RNAi screens

FBgn0038837

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG3822_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038837

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3822

Flygut - An atlas of the Drosophila adult midgut

FBgn0038837

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038837

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032203

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

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