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General Information
Symbol
Dmel\mttf06268
Species
D. melanogaster
Name
FlyBase ID
FBal0178962
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
PBac{WH}mttf06268
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The electrophysiological responses of the S3, S5 and S10 taste sensilla to L-canavanine are normal in both mttf06268 and mttf06268/Df(2R)Exel7096 flies.

mttf06268 flies show normal behavioural avoidance to L-canavanine in a two-way choice test.

mttf06268/mttf06268 and mttf06268/Df(2R)Exel7096 flies feed on a solution containing 30 mM L-canavanine (an insecticide), whereas control flies are repulsed by L-canavanine and avoid feeding on it.

L-canavanine triggers proboscis retraction in wild type flies but not in mttf06268 homozygous or mttf06268/Df(2R)Exel7096 flies.

Expression of mttdsRNA.Scer\UAS.RNAi using either Scer\GAL4NP4288 or Scer\GAL4Gr66a.PD in a mttf06268/+ background abolishes the L-canavanine-induced proboscis retraction seen in wild type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of mttScer\UAS.T:Ivir\HA1 using Scer\GAL4Gr66a.PD re-establishes L-canavanine-induced proboscis retraction in mttf06268 flies. In contrast, expressing mttScer\UAS.T:Ivir\HA1 using Scer\GAL4NP1017 or Scer\GAL4Tre.8.5.cCa does not rescue the mttf06268 phenotype.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)