FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

phospholipase C-activating G protein-coupled receptor signaling pathway

ID (Ontology)

GO:0007200 (Gene Ontology)

Definition

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.[ ISBN:0815316194 ]

Also Known As

"G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" ; "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" ; "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
phospholipase C-activating G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| phospholipase C-activating G protein-coupled receptor signaling pathway

Spanning Tree (Parents/Children)

  signal transduction
   |__G protein-coupled receptor signaling pathway
       |__phospholipase C-activating G protein-coupled receptor signaling pathway  26 rec.
           |__phospholipase C-activating adrenergic receptor signaling pathway
           |__phospholipase C-activating angiotensin-activated signaling pathway
           |__phospholipase C-activating dopamine receptor signaling pathway
           |__phospholipase C-activating endothelin receptor signaling pathway
           |__phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
           |__phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
           |__phospholipase C-activating N-formyl peptide-activated signaling pathway
           |__phospholipase C-activating opsin-mediated signaling pathway 6 rec.
           |__phospholipase C-activating serotonin receptor signaling pathway 2 rec.
           |__phospholipase C-activating tachykinin receptor signaling pathway
           |__regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 7 rec.
               |__negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway(+) 5 rec.
               |__positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 2 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	G protein-coupled receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT "PLC-activating GPCR signaling pathway" EXACT "protein kinase C-activating G protein-coupled receptor signaling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts