FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: GABA(B) RECEPTORS
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General Information
Name
GABA(B) RECEPTORS
Species
D. melanogaster
Symbol
GABA-B
FlyBase ID
FBgg0000078
Date last reviewed
2023-06-30
Number of members
3
Description
Description
Metabotropic GABA(B) receptors are Class C GPCRs. They function as obligate heterodimers, binding the inhibitory neurotransmitter GABA (γ-aminobutyric acid). (Adapted from FBrf0134605).
Notes on Group

GABA(B) receptors only form fully functional receptors upon heterodimerization between the two receptor subtypes R1 and R2. GABA-B-R1 and GABA-B-R2 form a functional heterodimer. GABA-B-R3 does not appear to have a mammalian counterpart and has not been functionally reconstituted as an active GPCR in vitro (FBrf0134605).

Source Material
The GABA(B) RECEPTORS Gene Group has been compiled using the following publication(s): Hanlon and Andrew, 2015, Mitri et al., 2004, Mezler et al., 2001, and Brody and Cravchik, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
G protein-coupled GABA receptor activity
Biological Process
gamma-aminobutyric acid signaling pathway
Cellular Component
plasma membrane
Related Gene Groups
Parent group(s)
CLASS C GPCRs
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
GABA-B
GABA(B) RECEPTORS
GABA-B receptor
Metabotropic GABA receptor
GABA GPCR
γ-aminobutyric acid GPCR
GABA(B)
GAGAB
Secondary FlyBase ID(s)
References (5)