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Citation
Chak, K., Kolodkin, A.L. (2014). Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance.  Development 141(1): 136--147.
FlyBase ID
FBrf0223742
Publication Type
Research paper
Abstract

The second messengers cAMP and cGMP modulate attraction and repulsion mediated by neuronal guidance cues. We find that the Drosophila receptor guanylyl cyclase Gyc76C genetically interacts with Semaphorin 1a (Sema-1a) and physically associates with the Sema-1a receptor plexin A (PlexA). PlexA regulates Gyc76C catalytic activity in vitro, and each distinct Gyc76C protein domain is crucial for regulating Gyc76C activity in vitro and motor axon guidance in vivo. The cytosolic protein dGIPC interacts with Gyc76C and facilitates Sema-1a-PlexA/Gyc76C-mediated motor axon guidance. These findings provide an in vivo link between semaphorin-mediated repulsive axon guidance and alteration of intracellular neuronal cGMP levels.

PubMed ID
PubMed Central ID
PMC3865755 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (3)
    Alleles (19)
    Genes (6)
    Physical Interactions (6)
    Cell Lines (3)
    Natural transposons (1)
    Insertions (17)
    Experimental Tools (3)
    Transgenic Constructs (13)