FlyBase Gene Report: Dmel\CG30371

General Information

Symbol

Dmel\CG30371

Species

D. melanogaster

Name

Annotation Symbol

CG30371

Feature Type

protein_coding_gene

FlyBase ID

FBgn0050371

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

chymotrypsin (3.4.21.1)

acrosin (3.4.21.10)

C-terminal processing peptidase (3.4.21.102)

cathepsin G (3.4.21.20)

coagulation factor VIIa (3.4.21.21)

coagulation factor IXa (3.4.21.22)

prolyl oligopeptidase (3.4.21.26)

coagulation factor XIa (3.4.21.27)

plasma kallikrein (3.4.21.34)

tissue kallikrein (3.4.21.35)

pancreatic elastase (3.4.21.36)

coagulation factor XIIa (3.4.21.38)

chymase (3.4.21.39)

trypsin (3.4.21.4)

complement subcomponent C1r (3.4.21.41)

complement subcomponent C1s (3.4.21.42)

classical-complement-pathway C3/C5 convertase (3.4.21.43)

complement factor I (3.4.21.45)

complement factor D (3.4.21.46)

alternative-complement-pathway C3/C5 convertase (3.4.21.47)

cerevisin (3.4.21.48)

thrombin (3.4.21.5)

endopeptidase La (3.4.21.53)

gamma-renin (3.4.21.54)

tryptase (3.4.21.59)

coagulation factor Xa (3.4.21.6)

kexin (3.4.21.61)

subtilisin (3.4.21.62)

t-plasminogen activator (3.4.21.68)

activated protein C (thrombin-activated peptidase) (3.4.21.69)

plasmin (3.4.21.7)

pancreatic elastase II (3.4.21.71)

u-plasminogen activator (3.4.21.73)

furin (3.4.21.75)

granzyme A (3.4.21.78)

granzyme B (3.4.21.79)

oligopeptidase B (3.4.21.83)

repressor LexA (3.4.21.88)

enteropeptidase (3.4.21.9)

endopeptidase Clp (3.4.21.92)

proprotein convertase 1 (3.4.21.93)

proprotein convertase 2 (3.4.21.94)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

44C3-44C3

Sequence location

2R:8,267,643..8,269,334 [-]

Recombination map

2-58

RefSeq locus

NT_033778 REGION:8267643..8269334

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from sequence model

(Cao and Jiang, 2018, Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa (3.4.21.1)

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa (3.4.21.10)

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa- Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus (3.4.21.102)

A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala- Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (3.4.21.102)

Specificity similar to chymotrypsin C (3.4.21.20)

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa (3.4.21.21)

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa (3.4.21.22)

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides (3.4.21.26)

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa (3.4.21.27)

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin (3.4.21.34)

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates (3.4.21.35)

Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa (3.4.21.35)

Hydrolysis of proteins, including elastin (3.4.21.36)

Preferential cleavage: Ala-|-Xaa (3.4.21.36)

Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa (3.4.21.38)

Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa (3.4.21.39)

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa (3.4.21.4)

Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3 (3.4.21.41)

4 (3.4.21.41)

21 (3.4.21.41)

42) (3.4.21.41)

Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase (3.4.21.42)

Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b (3.4.21.43)

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage (3.4.21.45)

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor (3.4.21.46)

Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b (3.4.21.47)

Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt (3.4.21.48)

Does not hydrolyze peptide amides (3.4.21.48)

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B (3.4.21.5)

Hydrolysis of proteins in presence of ATP (3.4.21.53)

Cleavage of the Leu-|-Leu bond in synthetic tetradecapeptide renin substrate, to produce angiotensin I, but not active on natural angiotensinogen (3.4.21.54)

Also hydrolyzes Bz-Arg-p-nitroanilide (3.4.21.54)

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin (3.4.21.59)

Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin (3.4.21.6)

Cleavage of -Lys-Arg-|-Xaa- and -Arg-Arg-|-Xaa- bonds to process yeast alpha-factor pheromone and killer toxin precursors (3.4.21.61)

Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1 (3.4.21.62)

Hydrolyzes peptide amides (3.4.21.62)

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin (3.4.21.68)

Degradation of blood coagulation factors Va and VIIIa (3.4.21.69)

Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin (3.4.21.7)

Converts fibrin into soluble products (3.4.21.7)

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa (3.4.21.71)

Hydrolyzes elastin (3.4.21.71)

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin (3.4.21.73)

Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys (3.4.21.75)

Releases albumin, complement component C3 and von Willebrand factor from their respective precursors (3.4.21.75)

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin (3.4.21.78)

Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates (3.4.21.78)

Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa- (3.4.21.79)

Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline (3.4.21.83)

Hydrolysis of Ala-|-Gly bond in repressor LexA (3.4.21.88)

Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond (3.4.21.9)

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium (3.4.21.92)

alpha-casein is the usual test substrate (3.4.21.92)

In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs) (3.4.21.92)

Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds (3.4.21.93)

Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds (3.4.21.94)

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - TRYPSIN-LIKE -: Trypsin-like serine proteases of the S1A family are endopeptidases that cleave amide substrates following Arginine or Lysine at the P1 position. (Adapted from FBrf0239469).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG30371 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A1Z7D2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG30371-RA

FBtr0088798

NM_136526

1258

399

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG30371-PA

FBpp0087874

43.6

399

6.81

A1Z7D2

NP_610370

AAF59107

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A1Z7D2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG30371 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG30371_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.18

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

spermatheca

(Prokupek et al., 2009)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

leg disc | restricted

(Grubbs et al., 2013)

antennal disc | restricted

(Grubbs et al., 2013)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG30371 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG30371

View exonic expression by tissue for Dmel\CG30371

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35806/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050371

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050371

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050371

Flygut - An atlas of the Drosophila adult midgut

FBgn0050371

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG30371

Transgenic constructs containing regulatory region of CG30371

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6057

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG30371^GD5453

viable, with Scer\GAL4^Mef2.PR

CG30371^GD5453

viable, with Scer\GAL4^pnr-MD237

CG30371^GD5453

Other Phenotypes

Allele

visible, with Scer\GAL4^Dll-md23

CG30371^KK110435

Phenotype manifest in

Allele

antenna, with Scer\GAL4^Dll-md23

CG30371^KK110435

leg | ectopic, with Scer\GAL4^Dll-md23

CG30371^KK110435

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (93)

Hsap\C1RL

2 of 14

Yes

Hsap\C1S

2 of 14

Yes

Hsap\CORIN

2 of 14

Yes

Hsap\MASP1

2 of 14

Yes

Hsap\MASP2

2 of 14

Yes

Hsap\ST14

2 of 14

Yes

Hsap\TMPRSS6

2 of 14

Yes

Hsap\ACR

1 of 14

Hsap\C1R

1 of 14

Hsap\C2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CFD

1 of 14

Hsap\CFI

1 of 14

Yes

Hsap\CMA1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (75)

Rnor\Corin

2 of 14

Yes

Rnor\St14

2 of 14

Yes

Rnor\Tmprss6

2 of 14

Yes

Rnor\Acr

1 of 14

Rnor\C1rl

1 of 14

Yes

Rnor\C1r

1 of 14

Yes

Rnor\C1s

1 of 14

Yes

Rnor\C2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Masp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (91)

Mmus\Masp2

2 of 14

Yes

Mmus\St14

2 of 14

Yes

Mmus\Tmprss6

2 of 14

Yes

Mmus\1810009J06Rik

1 of 14

Mmus\2210010C04Rik

1 of 14

Mmus\C1ra

1 of 14

Yes

Mmus\C1rb

1 of 14

Yes

Mmus\C1rl

1 of 14

Yes

Mmus\C1s1

1 of 14

Yes

Mmus\C1s2

1 of 14

Yes

Mmus\C2

1 of 14

Yes

Mmus\Cela2a

1 of 14

Mmus\Cfb

1 of 14

Yes

Mmus\Cma2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Mcpt2

1 of 14

Yes

Mmus\Mcpt4

1 of 14

Yes

Mmus\Mcpt9

1 of 14

Yes

Mmus\Mcptl

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (57)

Xtro\corin

2 of 13

Yes

Xtro\LOC100490440

2 of 13

Yes

Xtro\masp2

2 of 13

Yes

Xtro\tmprss6

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cfd

1 of 13

Xtro\efcab7

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (62)

Drer\c1r

2 of 14

Yes

Drer\f7l

2 of 14

Yes

Drer\LOC100004411

2 of 14

Yes

Drer\masp1

2 of 14

Yes

Drer\masp2

2 of 14

Yes

Drer\bfb

1 of 14

Yes

Drer\c1s.2

1 of 14

Yes

Drer\cela1.4

1 of 14

Drer\cela1.6

1 of 14

Drer\cfb

1 of 14

Yes

Drer\cfbl

1 of 14

Yes

Drer\cfd

1 of 14

Drer\col14a1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch1073-280e3.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\D1081.19

1 of 14

Yes

Cele\F25E5.3

1 of 14

Yes

Cele\F25E5.4

1 of 14

Yes

Cele\F25E5.7

1 of 14

Yes

Cele\svh-1

1 of 14

Yes

Cele\T21E12.3

1 of 14

Yes

Cele\try-1

1 of 14

Yes

Cele\try-4

1 of 14

Yes

Cele\try-5

1 of 14

Yes

Cele\try-6

1 of 14

Yes

Cele\try-7

1 of 14

Yes

Cele\try-8

1 of 14

Yes

Cele\try-9

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (234)

Agam\AgaP_AGAP011908

10 of 12

Yes

5 of 12

3 of 12

3 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011430

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012614

1 of 12

Agam\AgaP_AGAP012736

1 of 12

Agam\AgaP_AGAP012843

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\CLIPE4

1 of 12

Agam\CLIPE5

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG30371. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (184)

9 of 13

7 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

mas

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

teq

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

flz

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

MP1

1 of 13

ndl

1 of 13

Phae1

1 of 13

Phae2

1 of 13

psh

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

snk

1 of 13

Sp7

1 of 13

Sp212

1 of 13

SPE

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tpr

1 of 13

Try29F

1 of 13

yip7

1 of 13

ζTry

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

MASP1; MBL associated serine protease 1

model of 3MC syndrome 1

IEA

(FlyBase, 2019-)

C1S; complement C1s

model of Ehlers-Danlos syndrome periodontal type 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0050371

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-58

Cytogenetic map

44C3-44C3

Sequence location

2R:8,267,643..8,269,334 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44C3-44C3

Limits computationally determined from genome sequence between P{lacW}Rs1^k09514&P{lacW}l(2)k03110^k03110 and P{lacW}Vps25^k08904&P{lacW}ptc^k02507

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-58

(FlyBase, 2016)

2-57.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41608

y¹ v¹; P{TRiP.GL01190}attP40

43307

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02691}attP2

92675

y¹ w^*; TI{CRIMIC.TG4.1}CG30371^{CR02459-TG4.1}/SM6a

NIG-Fly

30371R-1

P{NIG.30371R}1

HMS02691

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02691}attP2

2RG-0880

y² VhaAC39-1^cho-1 v¹; P{U6-CG30371.NIG.sgRNA}attP40/CyO

VDRC

v102030

P{KK110435}VIE-260B

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0050371

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0050371

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Annotation CG2280 split into CG30371 and CG30375 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG2280

CG30371

(Avila et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Kumar et al., 2021, Zhou et al., 2021, Gene Disruption Project members, 2018-, Grubbs et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Prokupek et al., 2009)

SP80

(Ross et al., 2003)

SP80a

(Cao and Jiang, 2018)

Name Synonyms

Secondary FlyBase IDs

FBgn0033281

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35806

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF59107

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A1Z7D2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A1Z7D2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A1Z7D2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35806/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0050371

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0050371

FlyMine - An integrated database for Drosophila genomics

FBgn0050371

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30371

MARRVEL_MODEL - MARRVEL (model organism gene)

35806

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0050371

DroID - A comprehensive database of gene and protein interactions.

FBgn0050371

DRSC - Results frm RNAi screens

FBgn0050371

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG30371_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050371

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0050371

Flygut - An atlas of the Drosophila adult midgut

FBgn0050371

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033681

References (29)

The following external sites may use different assemblies or annotations than FlyBase.

0.18

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