FlyBase Gene Report: Dmel\Cda5

General Information

Symbol

Dmel\Cda5

Species

D. melanogaster

Name

Chitin deacetylase-like 5

Annotation Symbol

CG31973

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051973

Gene Model Status

Current

Stock Availability

16 publicly available

Enzyme Name (EC)

chitin deacetylase (3.5.1.41)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

21B1-21B1

Sequence location

2L:25,402..65,404 [-]

Recombination map

2-0.5

RefSeq locus

NT_033779 REGION:25402..65404

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508

(InterPro Project Members, 2004-)

enables chitin deacetylase activity

inferred from sequence or structural similarity with UniProtKB:Q9VW34

(Gene Ontology Curators, 2002-)

enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

inferred from electronic annotation with InterPro:IPR002509

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR002509, InterPro:IPR011330

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from electronic annotation with InterPro:IPR002557

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CHITIN DEACETYLASES

CHITIN BINDING DOMAIN-CONTAINING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

chitin deacetylase activity

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate (3.5.1.41)

RHEA 10464:

Summaries

Gene Group (FlyBase)

CHITIN DEACETYLASES -: Chitin deacetylases are secreted enzymes that deacetylate chitin to chitosan. (Adapted from FBrf0204376.)
CHITIN BINDING DOMAIN-CONTAINING PROTEINS -: Chitin binding domains are found in certain classes of chitin binding proteins and chitin-active enzymes. (Adapted from FBrf0108362.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cda5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPI3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.40

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cda5-RA

FBtr0078163

NM_164353

4350

1039

Cda5-RB

FBtr0078164

NM_164354

7227

1998

Cda5-RE

FBtr0113416

NM_001103575

4347

1040

Cda5-RF

FBtr0309225

NM_001258876

6150

1562

Cda5-RG

FBtr0309226

NM_001258877

6583

1790

Cda5-RH

FBtr0309227

NM_001258878

3917

891

Cda5-RI

FBtr0309228

NM_001258879

7266

1850

Cda5-RJ

FBtr0309229

NM_001103574

7005

1890

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cda5-PA

FBpp0077821

117.0

1039

7.04

FBpp0077822

221.4

1998

9.00

FBpp0112328

117.3

1040

7.19

FBpp0301164

175.4

1562

8.59

FBpp0301165

200.8

1790

8.33

FBpp0301166

101.0

891

6.83

FBpp0301167

205.4

1850

8.98

FBpp0301168

212.0

1890

7.98

A8DYS5

NP_001097044

ABV53594

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cda5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

larval foregut atrium

(Fisher et al., 2012)

dorsal head epidermis

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Dorus et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cda5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cda5

View exonic expression by tissue for Dmel\Cda5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051973

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33158/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051973

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051973

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051973

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31973

Flygut - An atlas of the Drosophila adult midgut

FBgn0051973

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cda5

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cda5

Transgenic constructs containing regulatory region of Cda5

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(2L)Ir21a^Δ1

(Ni et al., 2016)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Cda5^c04017

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cda5^GD6548

viable, with Scer\GAL4^Mef2.PR

Cda5^GD6548

viable, with Scer\GAL4^pnr-MD237

Cda5^GD6548

Sterility

Allele

fertile

Cda5^c04017

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\CTBS

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Ctbs

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Ctbs

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (5)

Drer\chia.1

1 of 14

Yes

Drer\chia.2

1 of 14

Yes

Drer\chia.3

1 of 14

Yes

Drer\chia.6

1 of 14

Yes

Drer\ctbs

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\lgx-1

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (46)

Agam\AgaP_AGAP008512

9 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cda5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (53)

7 of 13

6 of 13

6 of 13

6 of 13

4 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

teq

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59423

DroID - A comprehensive database of gene and protein interactions.

FBgn0051973

MIST (protein-protein) - An integrated Molecular Interaction Database

33158

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

chitin deacetylation

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-0.5

Cytogenetic map

21B1-21B1

Sequence location

2L:25,402..65,404 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21B1-21B1

Limits computationally determined from genome sequence between P{lacW}spen^k06805&P{lacW}l(2)k13604^k13604 and P{lacW}U2af38^k14504

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-0.5

(FlyBase, 2016)

2-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

72515

w¹¹¹⁸; P{VT000025-GAL4.DBD}attP2

11335

w¹¹¹⁸; PBac{PB}Cda5^c04017

23784

w¹¹¹⁸; Mi{ET1}Cda5^MB02050

63752

w¹¹¹⁸; PBac{IT.GAL4}Cda5^0705-G4

66197

w¹¹¹⁸; PBac{IT.GAL4}Cda5^1308-G4

51065

y¹ w^*; Mi{MIC}Cda5^MI06357

Korea

13636

P{VT000025-GAL4}attP2

14034

P{VT000025-lexA::GADfl}attP40

31973R-2

31973R-3

v104771

v16876

w¹¹¹⁸; P{GD6548}v16876/CyO

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH43162

Other clones

FI04738

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051973

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051973

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG31973 BcDNA:RH43162

(FlyBase, 1996-)

Source for merge of: CG2761 CG2776

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG2761 and CG2776 merged as CG31973 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG31973 BcDNA:RH43162 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Cda5 CG31973

(Dixit et al., 2008)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

BcDNA:RH43162

CG2761

(Ponting et al., 2001)

CG2776

CG31973

(National Institute of Genetics Fly Stocks, 2022-, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Yamamoto et al., 2009.2.25, Khokhar et al., 2008, Grzeschik et al., 2007, Dorus et al., 2006, Staudt et al., 2005)

Cda5

(Kosakamoto et al., 2024, Hall et al., 2021, Kumar et al., 2021, Clandinin and Owens, 2016-, Sytnikova et al., 2014, Kwon et al., 2013, Ohtani et al., 2013, Rodriguez et al., 2012)

DmCDA5

(Dixit et al., 2008)

Name Synonyms

CG31973

Chitin deacetylase-like 5

Secondary FlyBase IDs

FBgn0031210
FBgn0031211
FBgn0063656

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 67 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33158

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPI3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPI3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051973

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33158/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051973

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051973

FlyMine - An integrated database for Drosophila genomics

FBgn0051973

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31973

MARRVEL_MODEL - MARRVEL (model organism gene)

33158

Linkouts

BioGRID - A database of protein and genetic interactions.

59423

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051973

DroID - A comprehensive database of gene and protein interactions.

FBgn0051973

DRSC - Results frm RNAi screens

FBgn0051973

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051973

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051973

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

chitin deacetylation

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31973

Flygut - An atlas of the Drosophila adult midgut

FBgn0051973

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006846

MIST (protein-protein) - An integrated Molecular Interaction Database

33158

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

-0.79

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