IDGF, BG:DS02780.4 , DmIDGF2
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.50
1.390 (longest cDNA)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idgf2 using the Feature Mapper tool.
qRT-PCR shows that Idgf2 is expressed at all stages with the highest levels in pupae and adult males. In situ hybridization in larvae shows fat body as the major site of expression.
Idgf2 transcripts are expressed at all stages tested on northern blots but most heavily in mid-larval stages. Idgf2 transcripts are present in the yolk cytoplasm in the early embryo but are excluded from the blastoderm as it cellularizes. During gastrulation, transcripts are observed in rows parallel to the major invaginations including the ventral furrow, the cephalic furrow, and the anterior and posterior midgut invaginations. In late embryos, Idgf2 transcripts are observed in yolk cells, fat body, salivary glands, and in the tracheal system. In third instar larvae, Idgf2 transcripts are strongly expressed in fat body, the ring gland, and in lymph glands. Expression is also observed in the optic lobes, the central brain, and in imaginal discs. Duing oogenesis, Idgf2 transcripts are present in nurse cells and in the oocyte. While the patterns of expression of the four Idgf genes are in general very similar, they are differentially expressed in the larval salivary glands. Levels of Idgf2 and Idgf4 are generally higher than Idgf1 and Idgf3.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Idgf2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Idgf2 CG4475
Maps to subclone 9-a11 of P1 DS02780.
Candidate gene for tibia length quantitative trait locus.
Encodes a soluble growth factor that works in combination with insulin to stimulate cell proliferation, cell polarisation and movement.