FlyBase Allele Report: Dmel\gd[2]

General Information

Symbol

Dmel\gd²

Species

D. melanogaster

Name

FlyBase ID

FBal0005010

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Also Known As

11-1524

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ponomareff et al., 2001)

Mutagen

ethyl methanesulfonate

(Konrad et al., 1988, Tearle and Nusslein-Volhard, 1987, Mohler, 1977)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G86A. Amino acid replacement: C29Y.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,987,601..11,987,601 [-]

Nucleotide change:

G11987601A

Reported nucleotide change:

G86A

Amino acid change:

C29Y | gd-PC; C29Y | gd-PD; C29Y | gd-PE; C29Y | gd-PF

Reported amino acid change:

C29Y

(Ponomareff et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg | maternal effect

(Mohler, 1977)

embryo | gastrula stage | maternal effect

(Mohler and Carroll, 1984)

filzkorper

(Ponomareff et al., 2001, Towb et al., 1998)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd¹⁹⁰)

(Ponomareff et al., 2001)

filzkorper (with gd^LF12)

(Ponomareff et al., 2001)

filzkorper (with gd^Li115)

(Ponomareff et al., 2001)

filzkorper (with gd^LQ4)

(Ponomareff et al., 2001)

filzkorper (with gd^Lu119)

(Ponomareff et al., 2001)

filzkorper (with gdⁿ²⁷)

(Ponomareff et al., 2001)

filzkorper (with gd^p18)

(Ponomareff et al., 2001)

filzkorper (with gd^TN124)

(Ponomareff et al., 2001)

filzkorper (with gd^VM90)

(Ponomareff et al., 2001)

filzkorper (with gd^VO27)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001, Towb et al., 1998)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹⁹⁰)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LF12)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Li115)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LQ4)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Lu119)

(Ponomareff et al., 2001)

ventral denticle belt (with gdⁿ²⁷)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^p18)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^TN124)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VM90)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VO27)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

100% of embryos derived from homozygous or gd²/Df(1)KA10 females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper).

(Ponomareff et al., 2001)

In embryos generated from gd² mothers, Tl is inactive, dl remains exclusively cytoplasmic and the embryos fail to form filzkorper and ventral denticles.

(Towb et al., 1998)

Injection of pll::tor^cGa into embryos from gd² mothers results in the appearance of filzkorper and ventral denticle belts.

(Galindo et al., 1995)

Cell intercalation in lateralized gd mutant embryos proceeds normally during germ band extension.

(Irvine and Wieschaus, 1994)

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other.

(Konrad et al., 1988)

75% of embryos derived from gd²/gd⁵ females have a class III phenotype; ventral cuticle is reduced, but some ventral abdominal setal belt material is retained, the anterior midgut invagination and ventral furrow are reduced or absent, gut formation is abnormal and the tracheal pits are located closer to the ventral midline than normal. 20% have a class II phenotype; embryos lack ventral cuticle, the filzkorper are present and increased amounts of cuticle show dorsal characteristics compared to wild-type. 36% of embryos derived from gd²/gd⁶ females hatch, 35% either do not complete head involution or develop into apparently normal L1 larvae which either fail to hatch or die soon after hatching, and 29% have a class III phenotype.

(Konrad et al., 1988)

Embryonic defects detectable at gastrulation.

(Mohler and Carroll, 1984)

Homozygous females lay eggs that fail to hatch.

(Mohler, 1977)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

gd² is a non-suppressor of partially lethal - majority die | recessive phenotype of cact⁷

(Qiu et al., 1998)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Injection of snk^Xa RNA does not rescue the dorsalised phenotype of embryos derived from gd²/gd² females.

(Ponomareff et al., 2001)

When pip^hs.PS is uniformly expressed in gd² females, the resulting embryos are dorsalised.

(Sen et al., 2000)

The zygotic semi-lethality of cact⁷ homozygotes is not suppressed by gd².

(Qiu et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

gd^VO27

(Ponomareff et al., 2001)

Partially complements

gd⁶

(Tearle and Nusslein-Volhard, 1987)

Fails to complement

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Mohler.

Comments

Approximate order of allelic severity, from weakest to strongest is: gd⁵ > gd¹ > gd³ > gd⁶ > gd² > gd⁴ > gd⁷ = gd⁸ = gd⁹ = gd¹⁰ = gd¹¹ = gd¹².

(Konrad et al., 1988)

Blocks production of extracellular Tl ligand, consequently signal transduction is not initiated and dl remains cytoplasmic.

(Gillespie and Wasserman, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

11-1524

(Mohler and Carroll, 1984, Mohler, 1977)

fs(1)M18^11-1524

gd^11-1524

(Tearle and Nusslein-Volhard, 1987)

gd²

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

Open Close