FlyBase Allele Report: Dmel\gd[1]

General Information

Symbol

Dmel\gd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005009

Feature type

allele

Associated gene

Dmel\gd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive hypomorphic allele - genetic evidence

(Konrad et al., 1988)

Mutagen

ethyl methanesulfonate

(Konrad et al., 1988, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

No nucleotide change is detected in the protein coding sequence or the introns.

(Ponomareff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive | heat sensitive

(Konrad et al., 1988)

hyperplasia

(Woods et al., 1997)

Phenotype Manifest In

filzkorper

(Ponomareff et al., 2001)

filzkorper (with Df(1)KA10)

(Ponomareff et al., 2001)

filzkorper (with gd¹⁹⁰)

(Ponomareff et al., 2001)

filzkorper (with gd^LF12)

(Ponomareff et al., 2001)

filzkorper (with gd^Li115)

(Ponomareff et al., 2001)

filzkorper (with gd^LQ4)

(Ponomareff et al., 2001)

filzkorper (with gd^Lu119)

(Ponomareff et al., 2001)

filzkorper (with gdⁿ²⁷)

(Ponomareff et al., 2001)

filzkorper (with gd^p18)

(Ponomareff et al., 2001)

filzkorper (with gd^TN124)

(Ponomareff et al., 2001)

filzkorper (with gd^VM90)

(Ponomareff et al., 2001)

ventral denticle belt

(Ponomareff et al., 2001)

ventral denticle belt (with Df(1)KA10)

(Ponomareff et al., 2001)

ventral denticle belt (with gd¹⁹⁰)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LF12)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Li115)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^LQ4)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^Lu119)

(Ponomareff et al., 2001)

ventral denticle belt (with gdⁿ²⁷)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^p18)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^TN124)

(Ponomareff et al., 2001)

ventral denticle belt (with gd^VM90)

(Ponomareff et al., 2001)

Detailed Description

Statement

Reference

4% of embryos derived from homozygous females have a class I phenotype (they are strongly dorsalised, lacking both ventral denticles and filzkorper), 27% have a class II phenotype (they lack ventral denticles but have filzkorper), 69% have a class III phenotype (they have ventral denticles) and 0% have a class H phenotype (they are phenotypically normal and hatch). 11% of embryos derived from gd¹/Df(1)KA10 females have a class I phenotype and 89% have a class II phenotype.

(Ponomareff et al., 2001)

Hyperplastic overgrowth mutant. Apico-lateral junctional complexes appear normal.

(Woods et al., 1997)

Transheterozygous combinations of gd mutations produce a range of cuticular phenotypes, ranging from cuticle only having dorsal characteristics, to cuticle having some ventral characteristics, such as ventral setal belts, depending on the alleles used. Some combinations of alleles complement each other. Homozygous gd¹ females show temperature sensitivity in the amount of hatching, and the severity of their offspring's dorsalised phenotype.

(Konrad et al., 1988)

98% of embryos derived from gd¹/gd⁶ females hatch. 90% of embryos derived from gd¹/gd⁵ females have a class III phenotype; ventral cuticle is reduced, but some ventral abdominal setal belt material is retained, the anterior midgut invagination and ventral furrow are reduced or absent, gut formation is abnormal and the tracheal pits are located closer to the ventral midline than normal.

(Konrad et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

gd^VO27

(Ponomareff et al., 2001)

Fails to complement

gd¹⁹⁰

(Ponomareff et al., 2001)

gd^LF12

(Ponomareff et al., 2001)

gd^LQ4

(Ponomareff et al., 2001)

gd^Li115

(Ponomareff et al., 2001)

gd^Lu119

(Ponomareff et al., 2001)

gd^TN124

(Ponomareff et al., 2001)

gd^VM90

(Ponomareff et al., 2001)

gdⁿ²⁷

(Ponomareff et al., 2001)

gd^p18

(Ponomareff et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

856

v¹ gd¹/FM3

Notes on Origin

Discoverer

Audit.

Comments

The addition of wild-type gd from the paternal genome does not alter the frequency of hatching in embryos derived from gd¹/gd¹⁰ transheterozygotes, indicating that the requirement for gd is strictly maternal. Germline clonal analysis shows that gd is required in the germline. Temperature shift experiments show that functional gd is required late in oogenesis and early in embryogenesis.

(Konrad et al., 1988)

Approximate order of allelic severity, from weakest to strongest is: gd⁵ > gd¹ > gd³ > gd⁶ > gd² > gd⁴ > gd⁷ = gd⁸ = gd⁹ = gd¹⁰ = gd¹¹ = gd¹².

(Konrad et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

fs(1)573

(Perrimon et al., 1986)

fs(1)A573

gd¹

(Popodi et al., 2010-)

gd⁵⁷³

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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