FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term serine-type peptidase activity ID (Ontology) GO:0008236 (Gene Ontology)
Definition Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 serine-type peptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | serine-type peptidase activity       --
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hydrolase activity
 |__peptidase activity___________________
 |__serine hydrolase activity____________|
catalytic activity, acting on a protein  |
 |__peptidase activity___________________|
                                         serine-type peptidase activity  257 rec.
                                          |__serine-type endopeptidase activity 229 rec.
                                          |__serine-type exopeptidase activity 17 rec.
                                              |__serine-type aminopeptidase activity 1 rec.
                                              |__serine-type carboxypeptidase activity(+) 6 rec.
                                              |__tripeptidyl-peptidase activity 2 rec.
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Is a peptidase activity
serine hydrolase activity
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Synonyms
  • "serine protease activity" NARROW
Secondary IDs
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Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin"
Reactome:R-HSA-2022383 "Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))"
Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:RCbl"
Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)"
Reactome:R-HSA-9839072 "HTRA2 degrades APP (Amyloid-beta precursor protein)"
Reactome:R-HSA-9839110 "HTRA2 degrades NDUFA13 (GRIM-19)"