FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term peptidase activity ID (Ontology) GO:0008233 (Gene Ontology)
Definition Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.[ EC:3 ]
Also Known As "hydrolase, acting on peptide bonds" ; "peptide hydrolase activity" ; "protease activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      25
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 peptidase activity (all annotations which use CV term, excluding "NOT" statements)       1     25
     enables | peptidase activity       --      25
 NOT | enables | peptidase activity       --     162
Spanning Tree (Parents/Children)
Only view relationship: 
catalytic activity
 |__hydrolase activity_______________________
 |__catalytic activity, acting on a protein__|
                                             peptidase activity  571 rec.
                                              |__aspartic-type peptidase activity 30 rec.
                                              |   |__aspartic-type endopeptidase activity(+) 29 rec.
                                              |__ATP-dependent peptidase activity 7 rec.
                                              |__cysteine-type peptidase activity 100 rec.
                                              |   |__cysteine-type deNEDDylase activity 2 rec.
                                              |   |__cysteine-type deubiquitinase activity(+) 46 rec.
                                              |   |__cysteine-type endopeptidase activity(+) 30 rec.
                                              |   |__cysteine-type exopeptidase activity(+) 6 rec.
                                              |   |__deSUMOylase activity 5 rec.
                                              |   |__deUFMylase activity 3 rec.
                                              |   |__gamma-glutamyl-peptidase activity 3 rec.
                                              |   |__ISG15-specific peptidase activity
                                              |   |__pyroglutamyl-peptidase activity 2 rec.
                                              |__endopeptidase activity 366 rec.
                                              |   |__aspartic-type endopeptidase activity(+) 29 rec.
                                              |   |__cysteine-type endopeptidase activity(+) 30 rec.
                                              |   |__glutamic-type endopeptidase activity
                                              |   |__metalloendopeptidase activity(+) 64 rec.
                                              |   |__oligopeptidase activity 3 rec.
                                              |   |__peptidoglycan endopeptidase activity(+)
                                              |   |__serine-type endopeptidase activity 224 rec.
                                              |   |__signal peptidase activity 8 rec.
                                              |   |__threonine-type endopeptidase activity 17 rec.
                                              |__exopeptidase activity 104 rec.
                                              |   |__aminopeptidase activity(+) 33 rec.
                                              |   |__carboxypeptidase activity(+) 30 rec.
                                              |   |__cysteine-type exopeptidase activity(+) 6 rec.
                                              |   |__dipeptidase activity(+) 9 rec.
                                              |   |__dipeptidyl-peptidase activity 8 rec.
                                              |   |__eoxin E4 synthase activity
                                              |   |__metalloexopeptidase activity(+) 70 rec.
                                              |   |__peptidyl-dipeptidase activity 3 rec.
                                              |   |__serine-type exopeptidase activity(+) 17 rec.
                                              |   |__tripeptidase activity(+)
                                              |__glutamic-type peptidase activity
                                              |   |__glutamic-type endopeptidase activity
                                              |__metallopeptidase activity 150 rec.
                                              |   |__metal-dependent deNEDDylase activity 2 rec.
                                              |   |__metal-dependent deubiquitinase activity 7 rec.
                                              |   |__metalloendopeptidase activity(+) 64 rec.
                                              |   |__metalloexopeptidase activity(+) 70 rec.
                                              |__omega peptidase activity 12 rec.
                                              |   |__beta-aspartyl-peptidase activity 2 rec.
                                              |   |__gamma-glutamyl-peptidase activity 3 rec.
                                              |   |__glutathione gamma-glutamate hydrolase 5 rec.
                                              |   |__leukotriene-C(4) hydrolase activity
                                              |   |__pyroglutamyl-peptidase activity 2 rec.
                                              |__serine-type peptidase activity 252 rec.
                                              |   |__serine-type endopeptidase activity 224 rec.
                                              |   |__serine-type exopeptidase activity(+) 17 rec.
                                              |__threonine-type peptidase activity 25 rec.
                                              |   |__beta-aspartyl-peptidase activity 2 rec.
                                              |   |__glutathione gamma-glutamate hydrolase 5 rec.
                                              |   |__threonine-type endopeptidase activity 17 rec.
                                              |__ubiquitin-like protein peptidase activity 77 rec.
                                                  |__deNEDDylase activity(+) 8 rec.
                                                  |__deSUMOylase activity 5 rec.
                                                  |__deubiquitinase activity(+) 58 rec.
                                                  |__deUFMylase activity 3 rec.
                                                  |__ISG15-specific peptidase activity
                                                  |__ubiquitin-like protein-specific endopeptidase activity(+) 2 rec.
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Is a hydrolase activity
catalytic activity, acting on a protein
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Synonyms
  • "hydrolase, acting on peptide bonds" EXACT
    "peptidase activity, acting on D-amino acid peptides" NARROW
    "peptidase activity, acting on L-amino acid peptides" NARROW
    "peptide hydrolase activity" EXACT
    "protease activity" EXACT
    "proteinase activity" NARROW
Secondary IDs
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EC:3.4.-.-
Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6"
Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl"
Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl"
Reactome:R-HSA-3065958 "An unknown protease degrades ACACA"
Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs"
Reactome:R-HSA-3139027 "Maturation of HIV Virion"
Reactome:R-HSA-376149 "Proteolytic processing of SLIT"
Reactome:R-HSA-4167501 "An unknown protease degrades ACACB"
Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)"
Reactome:R-HSA-5655483 "USP1 autocleavage"
Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB"
Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC"
Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)"