FlyBase Allele Report: Dmel\scrib[GD11663]

General Information

Symbol

Dmel\scrib^GD11663

Species

D. melanogaster

Name

FlyBase ID

FBal0210531

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

P{GD11663}

Also Known As

UAS-scrib^RNAi, UAS-scrib-RNAi, UAS-scrib-IR

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11663}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11663

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA

(Wu et al., 2021)

model of cancer

CEA

(Yang et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of carcinoma

is ameliorated by puc^UAS.cMa

(Wu et al., 2021)

is ameliorated by CtBP^HMS00677

(Wu et al., 2021)

is ameliorated by CtBP^JF01291

(Wu et al., 2021)

model of cancer

is ameliorated by Xbp1^UAS.s.Tag:V5

(Yang et al., 2022)

is ameliorated by Ire1^UAS.Tag:V5

(Yang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Clones expressing scrib^GD11663 (using P{CoinFLP-GAL4} and Scer\FLP1^ey.PN to stochastically generate patches of cells expressing Scer\GAL4^{Act5C.CoinFLP-FRT}) are eliminated from the adult eye.

Expression of scrib^GD11663 using P{AyGAL4} and Scer\FLP1^ey.PN to generate clones in the eye expressing Scer\GAL4^Act5C.PI results in pupal lethality.

(Bosch et al., 2015)

Expression under the control of Scer\GAL4^Mef2.PR results in late pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 100% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11663

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11663

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scrib^GD11663

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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