FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pucUASp.Tag:MYC
Open Close
General Information
Symbol
Dmel\pucUASp.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0193821
Feature type
allele
Associated gene
Dmel\puc
Associated Insertion(s)
Carried in Construct
P{UASp-puc.MYC}
Also Known As
UAS-myc-Puc
Key Links
Transgenic product class
wild_type
(McEwen and Peifer, 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(McEwen and Peifer, 2005)
Mutagen
in vitro construct
(McEwen and Peifer, 2005)
Progenitor genotype
Carried in construct
P{UASp-puc.MYC}
Cytology
Description

UASp regulatory sequences drive expression of puc, which is tagged at the N-terminal end with Tag:MYC.

(McEwen and Peifer, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
puc
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of pucScer\UAS.P\T.T:Hsap\MYC under the control of Scer\GAL4en-e16E, significantly reduces the amount of γ-radiation-induced apoptosis in the wing disc.

      Expression of pucScer\UAS.P\T.T:Hsap\MYC, under the control of Scer\GAL4en-e16E, results in misorientation of male external genitalia, while Scer\GAL4ptc-559.1-driven expression leads to an increased number of bristles.

      (McEwen and Peifer, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of pucScer\UAS.P\T.T:Hsap\MYC strongly suppresses the ectopic apoptosis in cells expressing Rho1Scer\UAS.cMa under the control of Scer\GAL4dpp.blk1.

      (Neisch et al., 2010)

      Coexpression of pucScer\UAS.P\T.T:Hsap\MYC does not block the apoptosis induced in the wing disc by expression of p53GUS.PB under the control of Scer\GAL4en-e16E.

      (McEwen and Peifer, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Act5C.PI/pucUASp.Tag:MYC partially rescues pucA251.1F3

      (McEwen and Peifer, 2005)
      Comments

      Expression of pucScer\UAS.P\T.T:Hsap\MYC at the time of clone induction (driven by Scer\GAL4Act5C.PI) rescues pucA251.1F3 cell viability in the wing disc, although fewer pucA251.1F3 clones are recovered compared to wild-type clones.

      (McEwen and Peifer, 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pucScer\UAS.P\T.T:Hsap\MYC
      pucUASp.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)