FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Mrp4
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General Information
Symbol
Dmel\Mrp4
Species
D. melanogaster
Name
Multidrug resistance protein 4
Annotation Symbol
CG14709
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263316
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Multidrug resistance protein 4 (Mrp4) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in the response to oxidative stress and hypoxia. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dMRP4, BEST:CK01227 , EP3221

Key Links
Genomic Location
Cytogenetic map
86E11-86E11
Sequence location
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11569250..11575937
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ABC-type transporter activity
inferred from electronic annotation with InterPro:IPR011527
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN009085477
(GO Reference Genome Project, 2011-)
enables ATP binding
(InterPro Project Members, 2004-)
enables ATP hydrolysis activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(InterPro Project Members, 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in determination of adult lifespan
inferred from mutant phenotype
(Huang et al., 2014)
involved_in response to anoxia
inferred from mutant phenotype
(Huang and Haddad, 2007)
involved_in response to hypoxia
inferred from mutant phenotype
(Huang and Haddad, 2007)
involved_in response to oxidative stress
inferred from mutant phenotype
(Huang et al., 2014)
involved_in wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598,FLYBASE:ap; FB:FBgn0267978
(Bejarano et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR011527
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001954549
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Snapshot
Multidrug resistance protein 4 (Mrp4) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in the response to oxidative stress and hypoxia. [Date last reviewed: 2019-09-12]
Gene Group (FlyBase)
ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mrp4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VGM1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mrp4-RB
FBtr0302027
NM_141829
4726
1316
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mrp4-PB
FBpp0291237
147.9
1316
7.64
Q9VGM1
NP_650086
AAF54656
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mrp4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.02

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mrp4 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mrp4
Transgenic constructs containing regulatory region of Mrp4
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage | conditional, with Scer\GAL4da.G32
lethal - all die before end of larval stage | conditional, with Scer\GAL4elav.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal locomotor behavior | progressive (with Mrp4M1)
abnormal locomotor behavior | progressive (with Mrp4M2)
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
abnormal oxidative stress response
abnormal oxidative stress response, with Scer\GAL4yolk
abnormal oxidative stress response (with Mrp4M1)
abnormal oxidative stress response (with Mrp4M2)
abnormal oxidative stress response | adult stage | RU486 conditional, with Scer\GAL4Switch1.106
abnormal oxidative stress response | adult stage | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
abnormal stress response, with Scer\GAL4Act.PU
abnormal stress response, with Scer\GAL4da.G32
abnormal stress response, with Scer\GAL4Ddc.PL
abnormal stress response, with Scer\GAL4drl.PU
abnormal stress response, with Scer\GAL4elav.PU
abnormal stress response (with Mrp4EP3177)
abnormal stress response (with Mrp4EP3221)
abnormal stress response (with Mrp4EP3328)
abnormal stress response (with Mrp4ex621)
abnormal stress response (with Mrp4ex661)
abnormal stress response | recessive
chemical sensitive, with Scer\GAL4da.G32
long lived | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
short lived
short lived, with Scer\GAL4da.PU
short lived (with Mrp4M1)
short lived (with Mrp4M2)
short lived | recessive
some die during larval stage | conditional, with Scer\GAL4da.G32
some die during larval stage | conditional, with Scer\GAL4elav.PU
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
larval intersegmental nerve, with Scer\GAL4elav-C155
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (16)
Hsap\ABCC4
13 of 14
Yes
Yes
2  
Hsap\ABCC1
6 of 14
No
No
2  
Hsap\ABCC3
6 of 14
No
No
Hsap\ABCC5
6 of 14
No
Yes
4  
Hsap\ABCC12
6 of 14
No
No
Hsap\ABCC2
5 of 14
No
No
Hsap\ABCC6
5 of 14
No
No
Hsap\ABCC8
5 of 14
No
Yes
Hsap\ABCC9
5 of 14
No
Yes
Hsap\ABCC10
5 of 14
No
No
Hsap\ABCC11
5 of 14
No
No
Hsap\CFTR
5 of 14
No
No
10  
Hsap\ABCD1
1 of 14
No
No
1  
Hsap\ABCD2
1 of 14
No
No
Hsap\ABCD3
1 of 14
No
No
Hsap\ABCD4
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Abcc4
14 of 14
Yes
Yes
Rnor\Abcc1
6 of 14
No
No
Rnor\Abcc2
6 of 14
No
No
Rnor\Abcc3
6 of 14
No
No
Rnor\Abcc5
6 of 14
No
Yes
Rnor\Abcc12
6 of 14
No
No
Rnor\Abcc6
5 of 14
No
No
Rnor\Abcc8
5 of 14
No
Yes
Rnor\Abcc9
5 of 14
No
Yes
Rnor\Abcc10
5 of 14
No
No
Rnor\Cftr
4 of 14
No
No
Rnor\LOC688708
1 of 14
No
Yes
Mus musculus (laboratory mouse) (12)
Mmus\Abcc4
14 of 14
Yes
Yes
Mmus\Abcc1
6 of 14
No
No
Mmus\Abcc3
6 of 14
No
No
Mmus\Abcc5
6 of 14
No
Yes
Mmus\Abcc12
6 of 14
No
No
Mmus\Abcc6
5 of 14
No
No
Mmus\Abcc8
5 of 14
No
Yes
Mmus\Abcc10
5 of 14
No
No
Mmus\Cftr
5 of 14
No
No
Mmus\Abcc2
4 of 14
No
No
Mmus\Abcc9
4 of 14
No
Yes
Mmus\Gm10768
2 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (24)
Xtro\abcc4
8 of 13
Yes
Yes
Xtro\abcc2
3 of 13
No
No
Xtro\abcc5
3 of 13
No
Yes
Xtro\cstf2
3 of 13
No
No
Xtro\abcc8
2 of 13
No
No
Xtro\abcc9
2 of 13
No
No
Xtro\abcc10
2 of 13
No
No
Xtro\cftr
2 of 13
No
No
Xtro\LOC100493583
2 of 13
No
No
Xtro\abcc3
1 of 13
No
No
Xtro\abcc6
1 of 13
No
No
Xtro\abcc12
1 of 13
No
No
Xtro\abcd1
1 of 13
No
No
Xtro\eno1
1 of 13
No
No
Xtro\hspa1b
1 of 13
No
No
Xtro\hspb1
1 of 13
No
No
Xtro\ice1
1 of 13
No
Yes
Xtro\LOC100485969
1 of 13
No
No
Xtro\LOC100493925
1 of 13
No
No
Xtro\LOC116406449
1 of 13
No
No
Xtro\qki
1 of 13
No
No
Xtro\selenoo
1 of 13
No
No
Xtro\swsap1
1 of 13
No
Yes
Xtro\tmem198
1 of 13
No
No
Danio rerio (Zebrafish) (17)
Drer\abcc4
14 of 14
Yes
Yes
Drer\abcc2
6 of 14
No
No
Drer\abcc5
6 of 14
No
Yes
Drer\abcc6a
6 of 14
No
No
Drer\abcc12
6 of 14
No
No
Drer\abcc1
5 of 14
No
No
Drer\abcc3
5 of 14
No
No
Drer\abcc6b.2
5 of 14
No
No
Drer\abcc8b
5 of 14
No
Yes
Drer\abcc8
5 of 14
No
Yes
Drer\abcc9
5 of 14
No
Yes
Drer\abcc10
5 of 14
No
No
Drer\cftr
5 of 14
No
No
Drer\wu:fb13g09
5 of 14
No
No
Drer\abcc13
3 of 14
No
No
Drer\abcc6b.1
1 of 14
No
No
Drer\LOC110439293
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (20)
Cele\mrp-6
11 of 14
Yes
Yes
Cele\cft-1
5 of 14
No
No
Cele\mrp-2
5 of 14
No
No
Cele\mrp-3
5 of 14
No
No
Cele\mrp-4
5 of 14
No
No
Cele\mrp-5
5 of 14
No
Yes
Cele\mrp-7
5 of 14
No
No
Cele\mrp-1
4 of 14
No
No
Cele\mrp-8
4 of 14
No
No
Cele\haf-4
1 of 14
No
No
Cele\haf-7
1 of 14
No
No
Cele\haf-9
1 of 14
No
No
Cele\pgp-4
1 of 14
No
No
Cele\pgp-6
1 of 14
No
No
Cele\pgp-11
1 of 14
No
No
Cele\pmp-1
1 of 14
No
No
Cele\pmp-2
1 of 14
No
No
Cele\pmp-3
1 of 14
No
No
Cele\pmp-4
1 of 14
No
No
Cele\pmp-5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (17)
Agam\AgaP_AGAP006427
8 of 12
Yes
No
Agam\AgaP_AGAP001775
6 of 12
No
Yes
Agam\AgaP_AGAP001777
6 of 12
No
Yes
Agam\AgaP_AGAP003221
6 of 12
No
No
Agam\AgaP_AGAP004603
6 of 12
No
No
Agam\AgaP_AGAP004600
4 of 12
No
No
Agam\AgaP_AGAP004602
4 of 12
No
No
Agam\AgaP_AGAP008436
4 of 12
No
Yes
Agam\AgaP_AGAP008437
4 of 12
No
No
Agam\AgaP_AGAP009835
4 of 12
No
No
Agam\AgaP_AGAP007917
3 of 12
No
No
Agam\AgaP_AGAP012467
3 of 12
No
Yes
Agam\AgaP_AGAP012735
3 of 12
No
Yes
Agam\AgaP_AGAP012848
3 of 12
No
Yes
Agam\AgaP_AGAP009799
2 of 12
No
No
Agam\AgaP_AGAP000440
1 of 12
No
No
Agam\AgaP_AGAP002071
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (27)
Atha\ABCC3
6 of 13
Yes
Yes
Atha\ABCC6
6 of 13
Yes
Yes
Atha\ABCC7
6 of 13
Yes
Yes
Atha\ABCC1
5 of 13
No
No
Atha\ABCC2
5 of 13
No
No
Atha\ABCC4
5 of 13
No
No
Atha\ABCC5
5 of 13
No
No
Atha\ABCC8
5 of 13
No
No
Atha\ABCC9
5 of 13
No
No
Atha\ABCC10
5 of 13
No
No
Atha\ABCC11
5 of 13
No
No
Atha\ABCC12
5 of 13
No
No
Atha\ABCC14
5 of 13
No
No
Atha\ABCC15
5 of 13
No
No
Atha\ABCC13
4 of 13
No
No
Atha\NAP5
4 of 13
No
Yes
Atha\ABCA3
1 of 13
No
No
Atha\ABCA4
1 of 13
No
No
Atha\ABCA5
1 of 13
No
No
Atha\ABCA6
1 of 13
No
No
Atha\ABCA7
1 of 13
No
No
Atha\ABCB1
1 of 13
No
No
Atha\ABCB2
1 of 13
No
No
Atha\ABCB16
1 of 13
No
No
Atha\ABCD1
1 of 13
No
No
Atha\ABCF2
1 of 13
No
No
Atha\PGP10
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\BPT1
5 of 13
Yes
No
Scer\NFT1
5 of 13
Yes
Yes
Scer\VMR1
5 of 13
Yes
No
Scer\YBT1
5 of 13
Yes
No
Scer\YCF1
4 of 13
No
No
Scer\YOR1
3 of 13
No
No
Scer\YKR104W
2 of 13
No
No
Scer\ARB1
1 of 13
No
No
Scer\PXA1
1 of 13
No
No
Scer\PXA2
1 of 13
No
No
Scer\STE6
1 of 13
No
No
1  
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\abc3
5 of 12
Yes
No
Spom\abc2
4 of 12
No
No
Spom\abc4
4 of 12
No
Yes
Spom\ybt1
4 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\yejF
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mrp4. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
CG7627
13 of 13
CG9270
13 of 13
CG31792
13 of 13
l(2)03659
13 of 13
Mrp5
13 of 13
CG31793
12 of 13
rdog
11 of 13
Cftr
10 of 13
CG10505
10 of 13
CG11898
10 of 13
MRP
7 of 13
CG7806
6 of 13
Sur
3 of 13
Abcd1
1 of 13
Abcd3
1 of 13
CG10226
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 8 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCC4; ATP binding cassette subfamily C member 4 (PEL blood group)
    13 of 14
    605250
         
        ABCC1; ATP binding cassette subfamily C member 1 (ABCC1 blood group)
        6 of 14
        ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1; ABCC1
         
        ABCC3; ATP binding cassette subfamily C member 3
        6 of 14
        604323
            ABCC5; ATP binding cassette subfamily C member 5
            6 of 14
            605251
                 
                ABCC12; ATP binding cassette subfamily C member 12
                6 of 14
                607041
                    ABCC2; ATP binding cassette subfamily C member 2
                    5 of 14
                    601107
                    ABCC6; ATP binding cassette subfamily C member 6
                    5 of 14
                    603234
                    ABCC8; ATP binding cassette subfamily C member 8
                    5 of 14
                    600509
                    ABCC9; ATP binding cassette subfamily C member 9
                    5 of 14
                    601439
                    ABCC10; ATP binding cassette subfamily C member 10
                    5 of 14
                    612509
                        ABCC11; ATP binding cassette subfamily C member 11
                        5 of 14
                        607040
                          CFTR; CF transmembrane conductance regulator
                          5 of 14
                          CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR
                           
                          Functional Complementation Data
                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                          Interactions
                          Summary of Physical Interactions
                          Interaction Browsers
                          Summary of Genetic Interactions
                          Interaction Browsers
                          View in FlyBase Interactions Browser   View in MIST tool (external link)
                          Please look at the allele data for full details of the genetic interactions
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          Mrp4
                          suppressible
                          puc
                          (Huang et al., 2014)
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          mam
                          suppressible
                          Mrp4
                          (Kankel et al., 2007)
                          Ppt1
                          enhanceable
                          Mrp4
                          (Buff et al., 2007)
                          External Data
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          Pathways
                          Signaling Pathways (FlyBase)
                          Metabolic Pathways
                          FlyBase
                          External Links
                          External Data
                          Linkouts
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Class of Gene
                          Genomic Location and Detailed Mapping Data
                          Chromosome (arm)
                          3R
                          Recombination map
                          3-51
                          Cytogenetic map
                          86E11-86E11
                          Sequence location
                          FlyBase Computed Cytological Location
                          Cytogenetic map
                          Evidence for location
                          86E11-86E11
                          Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
                          Experimentally Determined Cytological Location
                          Cytogenetic map
                          Notes
                          References
                          Experimentally Determined Recombination Data
                          Location

                          3-51

                          (FlyBase, 2016)

                          3-48.5

                          (Comeron et al., 2012)
                          Left of (cM)
                          Right of (cM)
                          Notes
                          Stocks and Reagents
                          Stocks (13)
                          Genomic Clones (16)
                           

                          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                          cDNA Clones (23)
                           

                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                          cDNA clones, fully sequenced
                          BDGP DGC clones
                          Other clones
                            Drosophila Genomics Resource Center cDNA clones

                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                            cDNA Clones, End Sequenced (ESTs)
                            BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Cell Line Information
                              Publicly Available Cell Lines
                               
                                Other Stable Cell Lines
                                 
                                  Other Comments

                                  Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

                                  (Kopczynski et al., 1998)
                                  Relationship to Other Genes
                                  Source for database merge of

                                  Source for merge of: BEST:CK01227 CG14709

                                  (Bayraktaroglu, 2000.11.2)

                                  Source for merge of: CG14709 BEST:CK02472

                                  (Rana, 2004.7.8)

                                  Source for merge of: Mrp4 EP3221

                                  (Huang and Haddad, 2007)
                                  Additional comments
                                  Nomenclature History
                                  Source for database identify of

                                  Source for identity of: Mrp4 CG14709

                                  (Huang and Haddad, 2007)
                                  Nomenclature comments
                                  Etymology
                                  Synonyms and Secondary IDs (13)
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  Study result (0)
                                  Result
                                  Result Type
                                  Title
                                  External Crossreferences and Linkouts ( 41 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                  Other crossreferences
                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                  Linkouts
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  DroID - A comprehensive database of gene and protein interactions.
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  References (85)