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General Information
Symbol
Dmel\Mrp4EP3177
Species
D. melanogaster
Name
FlyBase ID
FBal0261006
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP3177
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    P{EP}Mrp4EP3177 is inserted 88 bp upstream of the Mrp4 transcription start site and directs over-expression of Mrp4 in the presence of Scer\GAL4.

    Insertion components
    P{EP}Mrp4EP3177
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In adult flies fed RU486, Mrp4EP3177 overexpressed by Scer\GAL4αTub84B.Switch.PK or Scer\GAL4Switch1.106 significantly improves survival rates in response to oxidative stress compared to wild type. Overexpression of Mrp4EP3177 by Scer\GAL4yolk increases survival rates in response to oxidative stress (paraquat) compared to wild type.

    With RU486 feeding, Mrp4EP3177 overexpressed by Scer\GAL4αTub84B.Switch.PK (but not Scer\GAL4Switch1.106) extends lifespan compared to siblings not fed RU486. Mrp4EP3177 overexpression by Scer\GAL4da.PU shortens lifespan compared to wild type.

    Flies expressing Mrp4EP3177 using Scer\GAL4da.G32, Scer\GAL4Act.PU, Scer\GAL4elav.PU, Scer\GAL4442 or Scer\GAL4Ddc.PL, but not Scer\GAL4repo.PU or Scer\GAL4how-24B, display a profound increase in recovery time after anoxia compared with controls.

    Mrp4EP3177/Mrp4EP3177, Mrp4EP3177/Mrp4EP3221 and Mrp4EP3177/Mrp4EP3328 flies show an increase in recovery time after anoxia compared with controls.

    Mrp4ex11/Mrp4EP3177 and Mrp4ex31/Mrp4EP3177 flies show the same recovery time after anoxia as controls.

    Mrp4EP3177/Mrp4ex661 and Mrp4EP3177/Mrp4ex621 flies show an increase in recovery time after anoxia compared with controls.

    No pupae form when Mrp4EP3177 is expressed with Scer\GAL4da.G32 or Scer\GAL4elav.PU under chronic hypoxia conditions. This is in contrast to Scer\GAL4how-24B Mrp4EP3177 flies and controls which show no larval developmental defects and die during late pupal stages under the same conditions.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Mrp4EP3177
    Name Synonyms
    Secondary FlyBase IDs
      References (2)