FlyBase Gene Report: Dmel\Sur

General Information

Symbol

Dmel\Sur

Species

D. melanogaster

Name

Sulfonylurea receptor

Annotation Symbol

CG5772

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028675

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Sulfonylurea receptor (Sur) encodes a predicted ATP-sensitive K[+] channel expressed almost exclusively in the embryonic heart. Sur loss in the adult heart causes increased oxidative stress and pacing-induced heart failure. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dSUR

Key Links

Genomic Location

Cytogenetic map

31B1-31B1

Sequence location

2L:10,182,557..10,199,117 [-]

Recombination map

2-40

RefSeq locus

NT_033779 REGION:10182557..10199117

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ABC-type transporter activity

inferred from electronic annotation with InterPro:IPR011527

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN009085477

(GO Reference Genome Project, 2011-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871, InterPro:IPR036640

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR036640

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in response to hypoxia

inferred from mutant phenotype

(Akasaka et al., 2006)

NOT involved_in chitin biosynthetic process

inferred from mutant phenotype

(Meyer et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000657997

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR011527

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002795584

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY

Protein Family (UniProt)

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (Q9VL32)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

Gene Group (FlyBase)

ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).

Protein Function (UniProtKB)

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.

(UniProt, Q9VL32)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sur for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VL32)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 6.13

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sur-RC

FBtr0452144

NM_001347812

7393

2223

Additional Transcript Data and Comments

Reported size (kB)

6.5 (northern blot)

(Nasonkin et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sur-PC

FBpp0402894

248.0

2223

7.03

NP_001334732

API64982

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

2167 (aa); 241.9 (kD predicted)

(Nasonkin et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sur using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sur_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

dorsal vessel wall cell

(Lo et al., 2007)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism | ubiquitous | uniform

(Nasonkin et al., 1999)

embryonic stage 2

organism | ubiquitous

(Nasonkin et al., 1999)

embryonic stage 10 -- 17

embryonic/larval dorsal vessel

(Nasonkin et al., 1999)

embryonic stage 11 -- 12

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

embryonic stage 12

cardiogenic mesoderm

(Akasaka et al., 2006)

embryonic stage 13 -- 16

larval circulatory system

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic stage 13 -- 17

dorsal vessel wall cell

(Akasaka et al., 2006)

embryonic stage 15 -- 17

embryonic/larval salivary gland

(Nasonkin et al., 1999)

larval tracheal system

(Nasonkin et al., 1999)

embryonic/larval posterior spiracle

(Nasonkin et al., 1999)

larval stage

(Nasonkin et al., 1999)

third instar larval stage

embryonic/larval corpus cardiacum

(Kim and Rulifson, 2004)

embryonic/larval corpus allatum

(Kim and Rulifson, 2004)

adult stage

(Nasonkin et al., 1999)

insulin secreting cell of pars intercerebralis

(Fridell et al., 2009)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult heart

(Akasaka et al., 2006)

adult head

(Akasaka et al., 2006)

adult abdomen

(Akasaka et al., 2006)

Additional Descriptive Data

Sur transcript expression begins in late embryonic stage 12, in the cardiac primordium, and continues throughout embryogenesis. From stage 13, Sur transcript expression is limited to tin-positive myocardial cells.

(Akasaka et al., 2006)

Maternally supplied Sur transcript is uniformly distributed in stage 1-2 embryos, but is no longer detectable by embryonic stage 3. Zygotic Sur transcript expression begins at embryonic stage 10, in the developing dorsal vessel. Expression is observed in all parts of the tracheal system beginning at stage 15.

(Nasonkin et al., 1999)

Marker for

dorsal vessel wall cell

(Lo et al., 2007)

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Sur-GAL4.B}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13

embryonic dorsal vessel

(Bryantsev and Cripps, 2012)

embryonic cardioblast

(Bryantsev and Cripps, 2012)

embryonic stage 16

embryonic dorsal vessel | variable

(Bryantsev and Cripps, 2012)

cardial cell | variable

(Bryantsev and Cripps, 2012)

pericardial cell | subset

(Bryantsev and Cripps, 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sur in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sur

View exonic expression by tissue for Dmel\Sur

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028675

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34350/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028675

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028675

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028675

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5772

Flygut - An atlas of the Drosophila adult midgut

FBgn0028675

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Sur

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sur

Transgenic constructs containing regulatory region of Sur

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)Exel6026

(Ryder, 2004.4.26)

Df(2L)Exel8024

(Ryder, 2004.4.26)

Df(2L)Exel9032

(Meyer et al., 2013, Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sur^GD398

viable, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

viable, with Scer\GAL4^Mef2.PR

Sur^GD398

viable, with Scer\GAL4^pnr-MD237

Sur^GD398

viable, with Scer\GAL4^tin.CΔ4

Sur^GD398

viable, with Scer\GAL4^Tub.PU

Other Phenotypes

Allele

abnormal immune response, with Scer\GAL4^hs.PB

Sur^RNAi.UAS.1-2

abnormal immune response, with Scer\GAL4^UAS.cHa, Scer\GAL4^tin.cBa

Sur^RNAi.UAS.1-2

abnormal stress response, with Scer\GAL4^how-24B, Scer\GAL4^twi.PG

abnormal stress response, with Scer\GAL4^UAS.cHa, Scer\GAL4^tin.cBa

Phenotype manifest in

Allele

adult heart, with Scer\GAL4^UAS.cHa, Scer\GAL4^tin.cBa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\ABCC8

4 of 14

Yes

Hsap\ABCC9

4 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Abcc8

4 of 14

Yes

Rnor\Abcc9

4 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (11)

Mmus\Abcc8

4 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (17)

Xtro\abcc9

4 of 13

Yes

Xtro\abcc8

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\abcc9

4 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (22)

Cele\mrp-3

2 of 14

Yes

Cele\mrp-7

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP009799

11 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (21)

Atha\ABCC1

3 of 13

Yes

Atha\ABCC2

3 of 13

Yes

Atha\ABCC11

3 of 13

Yes

Atha\ABCC12

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\BPT1

1 of 13

Yes

Scer\MDL1

1 of 13

Yes

Scer\MDL2

1 of 13

Yes

Scer\PXA1

1 of 13

Yes

Scer\PXA2

1 of 13

Yes

Scer\VMR1

1 of 13

Yes

Scer\YBT1

1 of 13

Yes

Scer\YCF1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\abc2

1 of 12

Yes

Spom\abc3

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\yejF

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sur. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

MRP

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 8 )

Human Ortholog

Disease

Evidence

References

ABCC9; ATP binding cassette subfamily C member 9

model of familial atrial fibrillation

IEA

(FlyBase, 2019-)

model of dilated cardiomyopathy 1O

IEA

(FlyBase, 2019-)

model of intellectual disability and myopathy syndrome

IEA

(FlyBase, 2019-)

model of hypertrichotic osteochondrodysplasia Cantu type

IEA

(FlyBase, 2019-)

ABCC8; ATP binding cassette subfamily C member 8

model of type 2 diabetes mellitus

IEA

(FlyBase, 2019-)

model of leucine-sensitive hypoglycemia of infancy

IEA

(FlyBase, 2019-)

model of familial hyperinsulinemic hypoglycemia 1

IEA

(FlyBase, 2019-)

model of transient neonatal diabetes mellitus 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Sur^MB07175

exacerbates mitochondrial metabolism disease

modeled by mt:ATPase6¹

(Fogle et al., 2016)

Sur^G7604

exacerbates mitochondrial metabolism disease

modeled by mt:ATPase6¹

(Fogle et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABCC8; ATP binding cassette subfamily C member 8

4 of 14

600509

ABCC9; ATP binding cassette subfamily C member 9

4 of 14

601439

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60441

DroID - A comprehensive database of gene and protein interactions.

FBgn0028675

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of insulin secretion

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-40

Cytogenetic map

31B1-31B1

Sequence location

2L:10,182,557..10,199,117 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31B1-31B1

Limits computationally determined from genome sequence between P{lacW}l(2)k06324^k06324 and P{lacW}me31B^k06607

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

31B3-31B3

(Thomas, 1999.7.9)

Experimentally Determined Recombination Data

Location

2-40

(FlyBase, 2016)

2-34.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27966

y¹ w^*; P{EP}Sur^G7604

34288

y¹ w^*; Mi{MIC}Sur^MI02189

93348

w^*; TI{CRIMIC.TG4.2}Sur^{CR60092-TG4.2}/CyO

65323

y¹ w^*; Mi{PT-GFSTF.0}Sur^{MI02189-GFSTF.0}/CyO

36087

y¹ sc^* v¹ sev²¹; P{TRiP.GL00506}attP2

79498

y¹ sc^* v¹ sev²¹; P{TKO.GS01940}attP40

81943

y¹ sc^* v¹ sev²¹; P{TKO.GS02477}attP40

NIG-Fly

M2L-0262

y¹ w¹¹¹⁸; Sur^SK3 P{neoFRT}40A/CyO-Tb

M2L-0263

y¹ w¹¹¹⁸; Sur^SK4 P{neoFRT}40A/CyO-Tb

VDRC

v104241

P{KK106264}VIE-260B

v6750

w¹¹¹⁸; P{GD398}v6750

v342576

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02316}attP40/CyO-GFP

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD08664

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028675

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028675

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

(Kopczynski et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Sur BEST:CK00325

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

BEST:CK00325

CG5772

(Wang et al., 2025, Wang et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Yurgel et al., 2019, Transgenic RNAi Project members, 2017-, Hosono et al., 2015, Meyer et al., 2013, Paulsen et al., 2013, Ni et al., 2011.7.19, Hazelett et al., 2009, Keleman et al., 2009.8.5, Mayer et al., 2009, Perkins et al., 2009, Shah et al., 2008, Croker et al., 2007, Dean et al., 2001)

CK00325

(Kopczynski et al., 1998)

DSur

(Ocorr et al., 2014)

DmSUR

(He et al., 2019)

Dme_CG5772

(Tarnay et al., 2004)

Dsur

(Lockwood and Bodmer, 2002, Nikitin and Thomas, 2000, Nikitin and Thomas, 2000, Nasonkin et al., 1999)

SUR

(Denecke, 2022.6.8, Denecke et al., 2022, Abo-Elghar et al., 2004, Wang et al., 2004, Thomas, 1999.7.9)

dSUR

(Yurgel et al., 2019, Zhu et al., 2017, Cannon and Bodmer, 2016, Eleftherianos and Castillo, 2012, Eleftherianos et al., 2011, Qian et al., 2011, Qian and Bodmer, 2009, Deddouche et al., 2008, Eleftherianos et al., 2008, Croker et al., 2007, Ocorr et al., 2007, Ocorr et al., 2007, Tountas and Fortini, 2007, Akasaka et al., 2006, Akasaka et al., 2006, Akasaka et al., 2005, Bier and Bodmer, 2004)

dSur

(Ly et al., 2018, Freeman et al., 2013, Fridell et al., 2009, Liu et al., 2009)

dsur

(Akasaka et al., 2006)

sur

(Dermauw and Van Leeuwen, 2014, Cripps and Olson, 2002)

Name Synonyms

Sulfonylurea receptor

(Shafer, 2025, Bryantsev and Cripps, 2012, Nasonkin et al., 1999)

Sulphonylurea receptor

(Hendren et al., 2007)

sulfonyl urea receptor

(Thomas, 1999.7.9)

sulfonylurea receptor

(Deddouche et al., 2008)

Secondary FlyBase IDs

FBgn0025710

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34350

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VL32

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VL32

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VL32

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028675

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34350/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028675

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028675

FlyMine - An integrated database for Drosophila genomics

FBgn0028675

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5772

MARRVEL_MODEL - MARRVEL (model organism gene)

34350

Linkouts

BioGRID - A database of protein and genetic interactions.

60441

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028675

DroID - A comprehensive database of gene and protein interactions.

FBgn0028675

DRSC - Results frm RNAi screens

FBgn0028675

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sur_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028675

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028675

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5772

Flygut - An atlas of the Drosophila adult midgut

FBgn0028675

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028675

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Regulation of insulin secretion

References (109)

The following external sites may use different assemblies or annotations than FlyBase.

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