FB2026_03 , released September 17, 2026
CV Term Report
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Term phosphoprotein phosphatase activity ID (Ontology) GO:0004721 (Gene Ontology)
Definition Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.[ ISBN:0198547684 ]
Also Known As"phosphoprotein phosphohydrolase activity" ; "protein phosphatase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphoprotein phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphoprotein phosphatase activity       --
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catalytic activity
 |__catalytic activity, acting on a protein__
phosphoric ester hydrolase activity          |
 |__phosphatase activity_____________________|
                                             phosphoprotein phosphatase activity  109 rec.
                                              |__[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
                                              |__[acetyl-CoA carboxylase]-phosphatase activity
                                              |__[glycogen-synthase-D] phosphatase activity
                                              |__[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
                                              |__[isocitrate dehydrogenase (NADP+)] phosphatase activity
                                              |__[phosphorylase] phosphatase activity
                                              |__[pyruvate kinase]-phosphatase activity
                                              |__histone phosphatase activity
                                              |   |__histone H2AXS139 phosphatase activity
                                              |   |__histone H2AXY142 phosphatase activity
                                              |__MAP kinase phosphatase activity 5 rec.
                                              |   |__MAP kinase serine/threonine phosphatase activity
                                              |   |__MAP kinase tyrosine phosphatase activity 2 rec.
                                              |   |__MAP kinase tyrosine/serine/threonine phosphatase activity 3 rec.
                                              |__myosin-light-chain-phosphatase activity
                                              |__protein arginine phosphatase activity 2 rec.
                                              |__protein histidine phosphatase activity 5 rec.
                                              |__protein serine/threonine phosphatase activity 64 rec.
                                              |   |__[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity 1 rec.
                                              |   |__calcium-dependent protein serine/threonine phosphatase activity(+) 4 rec.
                                              |   |__MAP kinase serine/threonine phosphatase activity
                                              |   |__myosin phosphatase activity 2 rec.
                                              |   |__RNA polymerase II CTD heptapeptide repeat phosphatase activity(+) 5 rec.
                                              |__protein tyrosine phosphatase activity 31 rec.
                                              |   |__MAP kinase tyrosine phosphatase activity 2 rec.
                                              |   |__non-membrane spanning protein tyrosine phosphatase activity 9 rec.
                                              |   |__protein tyrosine phosphatase activity, metal-dependent 2 rec.
                                              |   |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
                                              |__protein tyrosine/serine/threonine phosphatase activity 14 rec.
                                              |   |__JUN kinase phosphatase activity 2 rec.
                                              |   |__MAP kinase tyrosine/serine/threonine phosphatase activity 3 rec.
                                              |__protein tyrosine/threonine phosphatase activity 2 rec.
                                              |__transmembrane receptor protein phosphatase activity 8 rec.
                                                  |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
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Is a phosphatase activity
catalytic activity, acting on a protein
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Synonyms
  • "phosphoprotein phosphohydrolase activity" EXACT
    "protein phosphatase activity" EXACT
    "protein phosphatase-1 activity" NARROW
    "protein phosphatase-2A activity" NARROW
    "protein phosphatase-2B activity" NARROW
    "protein phosphatase-2C activity" NARROW
Secondary IDs
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EC:3.1.3.55
Reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
Reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin"
Reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A"
Reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A"
Reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
Reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases"
Reactome:R-HSA-170158 "CDC25A dephosphorylates CCNA:CDK1"
Reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B"
Reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2"
Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1"
Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1"
Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I"
Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"
Reactome:R-HSA-9636684 "NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP"