FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term phosphoprotein phosphatase activity ID (Ontology) GO:0004721 (Gene Ontology)
Definition Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.[ ISBN:0198547684 ]
Also Known As "phosphoprotein phosphohydrolase activity" ; "protein phosphatase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      21
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 phosphoprotein phosphatase activity (all annotations which use CV term, excluding "NOT" statements)       2     21
     enables | phosphoprotein phosphatase activity       --      21
Spanning Tree (Parents/Children)
Only view relationship: 
catalytic activity
 |__catalytic activity, acting on a protein__
phosphoric ester hydrolase activity          |
 |__phosphatase activity_____________________|
                                             phosphoprotein phosphatase activity  109 rec.
                                              |__[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
                                              |__[acetyl-CoA carboxylase]-phosphatase activity
                                              |__[glycogen-synthase-D] phosphatase activity
                                              |__[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
                                              |__[isocitrate dehydrogenase (NADP+)] phosphatase activity
                                              |__[phosphorylase] phosphatase activity
                                              |__[pyruvate kinase]-phosphatase activity
                                              |__histone phosphatase activity
                                              |   |__histone H2AXS139 phosphatase activity
                                              |   |__histone H2AXY142 phosphatase activity
                                              |__MAP kinase phosphatase activity 5 rec.
                                              |   |__MAP kinase serine/threonine phosphatase activity
                                              |   |__MAP kinase tyrosine phosphatase activity 2 rec.
                                              |   |__MAP kinase tyrosine/serine/threonine phosphatase activity 3 rec.
                                              |__myosin-light-chain-phosphatase activity
                                              |__protein arginine phosphatase activity 2 rec.
                                              |__protein histidine phosphatase activity 5 rec.
                                              |__protein serine/threonine phosphatase activity 62 rec.
                                              |   |__[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity 1 rec.
                                              |   |__calcium-dependent protein serine/threonine phosphatase activity(+) 4 rec.
                                              |   |__MAP kinase serine/threonine phosphatase activity
                                              |   |__myosin phosphatase activity 2 rec.
                                              |   |__RNA polymerase II CTD heptapeptide repeat phosphatase activity(+) 5 rec.
                                              |__protein tyrosine phosphatase activity 30 rec.
                                              |   |__MAP kinase tyrosine phosphatase activity 2 rec.
                                              |   |__non-membrane spanning protein tyrosine phosphatase activity 9 rec.
                                              |   |__protein tyrosine phosphatase activity, metal-dependent 2 rec.
                                              |   |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
                                              |__protein tyrosine/serine/threonine phosphatase activity 14 rec.
                                              |   |__JUN kinase phosphatase activity 2 rec.
                                              |   |__MAP kinase tyrosine/serine/threonine phosphatase activity 3 rec.
                                              |__protein tyrosine/threonine phosphatase activity 2 rec.
                                              |__transmembrane receptor protein phosphatase activity 8 rec.
                                                  |__transmembrane receptor protein tyrosine phosphatase activity 8 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a phosphatase activity
catalytic activity, acting on a protein
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "phosphoprotein phosphohydrolase activity" EXACT
    "protein phosphatase activity" EXACT
    "protein phosphatase-1 activity" NARROW
    "protein phosphatase-2A activity" NARROW
    "protein phosphatase-2B activity" NARROW
    "protein phosphatase-2C activity" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.1.3.55
Reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
Reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin"
Reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A"
Reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A"
Reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein"
Reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases"
Reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes"
Reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B"
Reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2"
Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1"
Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1"
Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I"
Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"
Reactome:R-HSA-9636684 "NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP"