FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

JNK cascade

ID (Ontology)

GO:0007254 (Gene Ontology)

Definition

A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.[ PubMed:11790549 PubMed:20811974 PubMed:23125017 ]

Also Known As

"c-Jun N-terminal kinase cascade" ; "MAPK8 cascade"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
JNK cascade (all annotations which use CV term, excluding "NOT" statements)
involved_in \| JNK cascade

Spanning Tree (Parents/Children)

  intracellular signaling cassette
   |__MAPK cascade
       |__JNK cascade  86 rec.
           |__JUN phosphorylation
           |__regulation of JNK cascade 73 rec.
               |__negative regulation of JNK cascade(+) 29 rec.
               |__positive regulation of JNK cascade 38 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	MAPK cascade
Part of
Synonyms & Secondary IDs
Synonyms
	"c-Jun N-terminal kinase cascade" EXACT[ PubMed:20811974 ] "JNK1 cascade" NARROW "JNK2 cascade" NARROW "JNK3 cascade" NARROW "MAPK10 cascade" NARROW "MAPK8 cascade" EXACT "MAPK9 cascade" NARROW "SAPK cascade" BROAD "stress-activated protein kinase cascade" BROAD
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-450321 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"