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General Information
Symbol
Dmel\Not3KK102144
Species
D. melanogaster
Name
FlyBase ID
FBal0231638
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Not3KK102144 under the control of Scer\GAL4ey.PH induces a fully penetrant small rough eye phenotype. The eye disc is mishappen, exhibits a significant decrease in cell divisions (BrdU labelling and pH3 immunostaining) and a significant increase in apoptosis (Dcp1a immunostaining), as compared to controls; differentiation is strongly inhibited, although some photoreceptors still form.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Enhancer of
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Addition of Not3KK102144 to the Scer\GAL4ey.PH DlScer\UAS.cDa background markedly increases tumor incidence in the eyes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Not3KK102144
l(2)NC136KK102144
Name Synonyms
Secondary FlyBase IDs
    References (3)