Open Close
General Information
Symbol
Dmel\domeΔTMCYT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0126405
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-domeDN, UAS-DomeDN
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a truncated form of dome which lacks the transmembrane and intracellular domains.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of domeΔTMCYT.Scer\UAS under the control of Scer\GAL4esg-NP5130 results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

Expression of domeΔTMCYT.Scer\UAS in visceral muscles under the control of Scer\GAL4how-24B results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

Scer\GAL4Myo31DF-NP0001-mediated expression of domeΔTMCYT.Scer\UAS results in significantly increased survival following infection with S. marcescens compared to controls.

Expression of domeΔTMCYT.Scer\UAS in border cells, driven by Scer\GAL4slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte.

Expression of domeΔTMCYT.Scer\UAS under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in segmentation defects in approximately 50% of embryos. The most frequent defects are deletions and fusions of segments A4 and A5.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The mitotic index in the gut of flies overexpressing Egfr::toract.Scer\UAS is decreased but not abolished when domeΔTMCYT.Scer\UAS is co-expressed under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
domeΔTMCYT.Scer\UAS
domeΔTMCYT.UAS
Name Synonyms
Secondary FlyBase IDs
    References (10)