FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsp68UAS.cWa
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General Information
Symbol
Dmel\Hsp68UAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wang
FlyBase ID
FBal0183165
Feature type
allele
Associated gene
Dmel\Hsp68
Associated Insertion(s)
Carried in Construct
P{UAS-Hsp68.W}
Key Links
Transgenic product class
cDNA
(Wang et al., 2003)
wild_type
(Wang et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wang et al., 2003)
wild_type
(Wang et al., 2003)
Mutagen
in vitro construct
(Wang et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Hsp68.W}
Cytology
Description

UASt regulatory sequences drive expression of full-length Hsp68 cDNA.

(Wang et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsp68
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Hsp68Scer\UAS.cWa under the control of Scer\GAL4esg-NP5130 in intestinal stem cell lineages extends lifespan in both males and females relative to isogenic wild-type controls. This overexpression also increases starvation tolerance in old flies compared with controls.

      (Biteau et al., 2010)

      Flies expressing Hsp68Scer\UAS.cWa, under the control of Scer\GAL4arm.PS, show a decreased sensitivity to paraquat compared to wild-type flies. Constitutive overexpression of Hsp68Scer\UAS.cWa, driven by Scer\GAL4arm.PS, extends the lifespan of flies.

      (Wang et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of both Hsp68Scer\UAS.cWa and Jafrac1Scer\UAS.cBa using the driver Scer\GAL4bun-GSG5961 results in a moderate but significant extension of lifespan compared with isogenic wild-type controls.

      (Biteau et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsp68Scer\UAS.cWa
      Hsp68UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wang
      (Wang et al., 2003)
      Secondary FlyBase IDs
        References (3)