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General Information
Symbol
Dmel\EgfrU.A887T.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0246628
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-EGFRA887T
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of activated Egfr.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of EgfrU.A887T.Scer\UAS under the control of Scer\GAL4esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in a significant increase in the number of mitotic cells in the midgut, as compared to controls.

Adult Scer\GAL4tin.CΔ4>EgfrU.A887T.Scer\UAS flies have smaller heart chambers with reduced end-diastolic dimensions compared with controls. Histological analysis of cardiac chambers from the adult transgenic flies show heart wall thicknesses that are two to three times compared with controls. Hearts isolated from the transgenic flies show abnormal cardiac morphology with myofiber disarray compared with controls. The number of cells in the transgenic hearts is similar to that in wild-type, indicating that the increased wall thickness is the result of cardiomyocyte hypertrophy, not an increase in cell proliferation.

Expression of EgfrU.A887T.Scer\UAS in differentiating eye cells driven by Scer\GAL4GMR.PU causes rough eyes of reduced size.

Expression of EgfrU.A887T.Scer\UAS under the control of Scer\GAL4sim.P3.7 results in an increased number of midline glia cells compared to wild type at stage 16 of embryogenesis.

Flies expressing EgfrU.A887T.Scer\UAS under the control of Scer\GAL4bbg-C96 have notches on the posterior half of the wing margin.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of bunGD1392 or MadmGD7155 suppresses the increased number of mitotic cells seen in the midguts of flies expressing EgfrU.A887T.Scer\UAS under the control of Scer\GAL4esg-NP5130.

Co-expression of Rabex-5VDRC.cUa significantly enhances the number of eyes with black tissue and significantly increases lethality resulting from the expression of EgfrU.A887T.Scer\UAS driven by Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference

Co-expression of Rat\NeuKDYD.Scer\UAS does not significantly reduce the increased number of midline glia cells at stage 16 of embryogenesis which are seen in animals expressing EgfrU.A887T.Scer\UAS under the control of Scer\GAL4sim.P3.7.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

This line is originally from the Bloomington Stock Center, so it could correspond to either Egfr1.A887T.Scer\UAS or Egfr2.A887T.Scer\UAS.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
EgfrU.A887T.Scer\UAS
EgfrU.A887T.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)