Expression of EgfrU.A887T.Scer\UAS under the control of Scer\GAL4esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in a significant increase in the number of mitotic cells in the midgut, as compared to controls.
Adult Scer\GAL4tin.CΔ4>EgfrU.A887T.Scer\UAS flies have smaller heart chambers with reduced end-diastolic dimensions compared with controls. Histological analysis of cardiac chambers from the adult transgenic flies show heart wall thicknesses that are two to three times compared with controls. Hearts isolated from the transgenic flies show abnormal cardiac morphology with myofiber disarray compared with controls. The number of cells in the transgenic hearts is similar to that in wild-type, indicating that the increased wall thickness is the result of cardiomyocyte hypertrophy, not an increase in cell proliferation.