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General Information
Symbol
Dmel\PEKGD5584
Species
D. melanogaster
Name
FlyBase ID
FBal0207969
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
perk RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of PEKGD5584 under the control of Scer\GAL4109(2)80 does not significantly affect the total branch length of the dendritic arbor in class IV ddaC neurons in third instar larvae.

Expression of PEKGD5584 under the control of Scer\GAL4bun-GSG5961, using RU486 food supplementation to induce the expression, extends adult lifespan relative to controls.

Adults expressing PEKGD5584 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prelScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109(2)80 is strongly mitigated by co-expression of any of PEKGD5584.

Expression of PEKGD5584 under the control of Scer\GAL4elav.PU significantly rescues the loss of dopaminergic neurons characteristic for either Pink1B9 or park25/park25 mutant adults.

The increased cell proliferation in the adult gut expressing hepScer\UAS.cBa or Ero1LGD3577 or NdsRNA.P.Scer\UAS under the control of Scer\GAL4esg-NP5130 (using tub-gal80[ts] to limit the time of expression) is suppressed by co-expression of PEKGD5584.

Co-expression of PEKGD5584 modestly rescues the developmental delay phenotype of animals expressing Gadd34GD5953 under the control of Scer\GAL4da.G32. However, these animals often die during eclosion from the pupal case, and surviving adults show severe mobility defects and have strongly reduced longevity.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
PEKGD5584
Name Synonyms
Secondary FlyBase IDs
    References (15)