FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\phylGD12579
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General Information
Symbol
Dmel\phylGD12579
Species
D. melanogaster
Name
FlyBase ID
FBal0210341
Feature type
allele
Associated gene
Dmel\phyl
Associated Insertion(s)
Carried in Construct
P{GD12579}
Also Known As
UAS.phylRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD12579}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD12579
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clonal expression of phylGD12579 under the control of Scer\GAL4Act.PU in the adult midgut results in a significantly decreased number of cells and a virtual lack of enteroendocrine cells within the clone, as compared to control clones.

      The expression of phylGD12579 under the control of Scer\GAL4esg-NP5130 in the adult midgut leads to the virtual absence of enteroendocrine cells, but has no obvious effect on the intestinal stem cell or enteroblast populations, as compared to controls.

      (Yin and Xi, 2018)

      Expression under the control of Scer\GAL4pnr-MD237 results in loss of bristles on the notum in 90-100% of the Scer\GAL4pnr-MD237 expression domain.

      Expression under the control of Scer\GAL4pnr-MD237 results in duplication of bristle hairs on the notum in 10-20% of the Scer\GAL4pnr-MD237 expression domain.

      Expression under the control of Scer\GAL4pnr-MD237 results in external sensory organs consisting of empty or multiple sockets in 10-20% of the Scer\GAL4pnr-MD237 expression domain of the notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      phylGD12579/Scer\GAL4ey.PU is a non-enhancer of visible | dominant phenotype of L2

      (Son and Choi, 2020)
      Suppressor of
      Statement
      Reference

      phylGD12579, Scer\GAL4NP5130 is a suppressor of neoplasia | adult stage phenotype of NRNAi.UAS.cUa, Scer\GAL4NP5130

      (Yin and Xi, 2018)
      NOT Suppressor of
      Statement
      Reference

      phylGD12579/Scer\GAL4ey.PU is a non-suppressor of visible | dominant phenotype of L2

      (Son and Choi, 2020)

      phylGD12579/Scer\GAL4NP5130 is a non-suppressor of increased cell number | adult stage phenotype of Scer\GAL4NP5130, ttkGD4414

      (Yin and Xi, 2018)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      phylGD12579/Scer\GAL4ey.PU is a non-enhancer of eye phenotype of L2

      (Son and Choi, 2020)
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severely increased number of enteroendocrine cells in the adult midgut resulting from the adulthood-only expression of ttkGD4414 under the control of Scer\GAL4esg-NP5130 (using Gal80[ts]) is not suppressed by the co-expression of phylGD12579.

      The co-expression of phylGD12579 suppress the abnormal adult midgut enteroendocrine cell-like tumors, but not the intestinal stem cell-like tumors, resulting from the expression of NdsRNA.Scer\UAS.cUa under the control of Scer\GAL4esg-NP5130 (using Gal80[ts] for the temporal control of expression).

      (Yin and Xi, 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      phylGD12579
      Name Synonyms
      Secondary FlyBase IDs
        References (9)