FlyBase Allele Report: Dmel\Dsor1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Dsor1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407436

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

P{UAS-Dsor1.RNAi.U}

Also Known As

UAS-MEK^RNAi

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Dsor1.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Dsor1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dsor1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cardiomyopathy

modeled by Hsap\RAF1^gof.UAS

(Yu et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^NP5130

(Jin et al., 2015)

Phenotype Manifest In

adult heart, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

adult heart muscle cell, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

adult midgut, with Scer\GAL4^NP5130

(Jin et al., 2015)

germarium, with Scer\GAL4^unspecified

(Liu et al., 2010)

intestinal stem cell | adult stage, with Scer\GAL4^NP5130

(Jin et al., 2015)

spectrosome | increased number, with Scer\GAL4^unspecified

(Liu et al., 2010)

Detailed Description

Statement

Reference

Expression of Dsor1^{dsRNA.Scer\UAS.cUa} RNAi under the control of Scer\GAL4^esg-NP5130 (using tub-Gal80[ts] to limit the time of RNAi expression) results in a suppression of regeneration-associated proliferation of intestinal stem cells in the adult midgut upon Pseudomonas entomophila enteric infection.

(Jin et al., 2015)

Hearts from Scer\GAL4^tin.CΔ4>Dsor1^{dsRNA.Scer\UAS.cUa} flies show slightly increased end-diastolic dimensions, significantly increased end-systolic dimensions, and thinner heart walls compared with controls.

(Yu et al., 2013)

Germaria expressing Dsor1^VDRC.cUa driven by Scer\GAL4^unspecified exhibit ectopic spectrosome containing cells.

(Liu et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dsor1^RNAi.UAS.cUa, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL is a suppressor of hyperplasia | conditional | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Dsor1^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4 has adult heart phenotype, non-enhanceable by Hsap\RAF1^gof.UAS, Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

Dsor1^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4 has adult heart muscle cell phenotype, non-enhanceable by Hsap\RAF1^gof.UAS, Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

NOT suppressed by

Statement

Reference

Dsor1^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4 has adult heart phenotype, non-suppressible by Hsap\RAF1^gof.UAS, Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

Dsor1^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4 has adult heart muscle cell phenotype, non-suppressible by Hsap\RAF1^gof.UAS, Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

Suppressor of

Statement

Reference

Dsor1^RNAi.UAS.cUa, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL is a suppressor of adult Malpighian tubule | conditional | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^FRT.Act5C, Scer\GAL80^αTub84B.PL

(Zeng et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The inhibition of the regeneration-associated proliferation of intestinal stem cells in adult midgut upon infection with Pseudomonas entomophila characteristic for flies expressing Dsor1^{dsRNA.Scer\UAS.cUa} RNAi under the control of Scer\GAL4^esg-NP5130 (using tub-Gal80[ts] to limit the time of RNAi expression) can be reverted by co-expression of Ets21C^Scer\UAS.cUa.

(Jin et al., 2015)

Hyperplasia in adult Malpighian tubule clones expressing Ras85D^V12.Scer\UAS (using the MARCM system, under the control of Scer\GAL80^αTub84B.PL and Scer\GAL4^{Scer\FRT.Act5C}) is suppressed by co-expression of Dsor1^VDRC.cUa.

(Zeng et al., 2010)

Xenogenetic Interactions

Statement

Reference

Cardiac-specific co-expression of Hsap\RAF1^gof.Scer\UAS does not change heart wall thickness and cardiomyocyte architecture in Scer\GAL4^tin.CΔ4>Dsor1^{dsRNA.Scer\UAS.cUa} expressing flies.

(Yu et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dsor1^RNAi.UAS.cUa

Dsor1^VDRC.cUa

Dsor1^{dsRNA.Scer\UAS.cUa}

Dsor1^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0290180
FBal0248867

References (7)

Report Sections

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