FlyBase Allele Report: Dmel\Stat92E[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Stat92E^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407478

Feature type

allele

Associated gene

Dmel\Stat92E

Associated Insertion(s)

Carried in Construct

P{UAS-Stat92E.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Stat92E.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi line that targets Stat92E.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Stat92E

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates intestinal cancer

modeled by Src64B^UAS.cUa

(Kohlmaier et al., 2015)

modeled by Src42A^CA.UAS

(Kohlmaier et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^how-24B

(Buchon et al., 2010)

abnormal immune response | adult stage, with Scer\GAL4^NP5130

(Buchon et al., 2010)

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^how-24B

(Buchon et al., 2010)

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^NP5130

(Buchon et al., 2010)

Phenotype Manifest In

midgut, with Scer\GAL4^how-24B, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

midgut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

wing hinge primordium | third instar larval stage, with Scer\GAL4^NP3253

(Wells et al., 2013)

wing hinge primordium | third instar larval stage, with Scer\GAL4^zfh2-MS209

(Wells et al., 2013)

Detailed Description

Statement

Reference

Expression of Stat92E^VDRC.cUa under the control of Scer\GAL4^ptc-NP3253 leads to apical opening and shallowing shallowing of the proximal and medial epithelial folds within the presumptive dorsal hinge region of late third instar wing discs.

Expression of Stat92E^VDRC.cUa under the control of Scer\GAL4^zfh2-MS209 leads to shallowing and opening of the apical region of the medial epithelial fold within the presumptive dorsal hinge region of late third instar wing discs.

(Wells et al., 2013)

Expression of Stat92E^NIG.cUa under the control of Scer\GAL4^esg-NP5130 results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

Expression of Stat92E^NIG.cUa in visceral muscles under the control of Scer\GAL4^how-24B results in decreased intestinal stem cells (ISC) proliferation in response to Erwinia carotovora carotovora 15 (Ecc15) infection compared with wild-type.

(Buchon et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Stat92E^RNAi.UAS.cUa/Scer\GAL4^NP7397 is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

Stat92E^RNAi.UAS.cUa/Scer\GAL4^NP7397 is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Stat92E^RNAi.UAS.cUa, Scer\GAL4^NP5130 is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Egfr::tor^act.UAS, Scer\GAL4^NP5130

(Buchon et al., 2010)

NOT Suppressor of

Statement

Reference

Stat92E^RNAi.UAS.cUa, Scer\GAL4^NP7397 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Krn^s.UAS.cRa, Scer\GAL4^NP7397

(Jiang et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Stat92E^RNAi.UAS.cUa/Scer\GAL4^NP7397 is a suppressor of adult midgut phenotype of Scer\GAL4^NP7397, Src64B^UY1332

(Kohlmaier et al., 2015)

Stat92E^RNAi.UAS.cUa/Scer\GAL4^NP7397 is a suppressor of adult midgut phenotype of Scer\GAL4^NP7397, Src42A^CA.UAS

(Kohlmaier et al., 2015)

Scer\GAL80^ts.αTub84B, Stat92E^RNAi.UAS.cUa, Scer\GAL4^NP5130 is a suppressor | partially of midgut phenotype of Egfr::tor^act.UAS, Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Buchon et al., 2010)

NOT Suppressor of

Statement

Reference

Scer\GAL80^ts.αTub84B, Stat92E^RNAi.UAS.cUa, Scer\GAL4^NP7397 is a non-suppressor of intestinal stem cell phenotype of Krn^s.UAS.cRa, Scer\GAL4^NP7397, Scer\GAL80^ts.αTub84B

(Jiang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The mitotic index in the gut of flies overexpressing Egfr::tor^act.Scer\UAS is decreased but not abolished when Stat92E^NIG.cUa is co-expressed under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B.

(Buchon et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Stat92E^NIG.cUa

Stat92E^RNAi.UAS.cUa

Stat92E^VDRC.cUa

Stat92E^{dsRNA.Scer\UAS.cUa}

Stat92E^{dsRNA.UAS.cUa}

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

FBal0285322
FBal0220977
FBal0290294

References (11)

Report Sections

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